Biodegradable magnesium alloy WE43 porous scaffolds fabricated by laser powder bed fusion for orthopedic applications: Process optimization, in vitro and in vivo investigation

Liu, Jinge; Liu, Bingchun; Min, Shuyuan; Yin, Bangzhao; Peng, Bo; Yu, Zishi; Wang, Caimei; Ma, Xiaolin; Wen, Peng; Tian, Yun; Zheng, Yufeng

doi:10.1016/j.bioactmat.2022.02.020

Cited by 52 publications

(26 citation statements)

References 68 publications

(153 reference statements)

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“…Further, the X-ray profile of the as-extruded WE43 alloy was displayed in Figure 2 f, and specific peaks from α-Mg matrix, Mg 12 Nd second phase, and Mg 41 Nd 5 were determined, illustrating the second phases observed in the SEM image was Mg 12 Nd and Mg 41 Nd 5 . These fine second-phase particles could provide a pinning effect inhibiting grain growth and dislocation movement, thereby refining the microstructure and enhancing the mechanical strength [ 26 ]. It is worth noting that the absence of the Mg-Y seconding phase may be due to the high solid solubility of Y in the Mg matrix (12.3 wt%) [ 27 ].…”

Section: Resultsmentioning

confidence: 99%

Effect of the Combination of Torsional and Tensile Stress on Corrosion Behaviors of Biodegradable WE43 Alloy in Simulated Body Fluid

Wang

Gao

Pan³

et al. 2023

JFB

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The real physiological environment of the human body is complicated, with different degrees and forms of loads applied to biomedical implants caused by the daily life of the patients, which will definitely influence the degradation behaviors of Mg-based biodegradable implants. In the present study, the degradation behaviors of modified WE43 alloys under the combination of torsional and tensile stress were systematically investigated. Slow strain rate tensile tests revealed that the simulated body fluid (SBF) solution could deteriorate the ultimate tensile stress of WE43 alloy from 210.1 MPa to 169.2 MPa. In the meantime, the fracture surface of the specimens tested in the SBF showed an intergranular corrosion morphology in the marginal region, while the central area appeared not to have been affected by the corrosive media. The bio-degradation performances under the combination of torsional and tensile stressed conditions were much more severe than those under unstressed conditions or single tensile stressed situations. The combination of 40 MPa tensile and 40 MPa torsional stress resulted in a degradation rate over 20 mm/y, which was much higher than those under 80 MPa single tensile stress (4.5 mm/y) or 80 MPa single torsional stress (13.1 mm/y). The dynamic formation and destruction mechanism of the protective corrosion products film on the modified WE43 alloy could attribute to the exacerbated degradation performance and the unique corrosion morphology. The dynamic environment and multi-directional loading could severely accelerate the degradation process of modified WE43 alloy. Therefore, the SCC susceptibility derived from a single directional test may be not suitable for practical purposes. Complex external stress was necessary to simulate the in vivo environment for the development of biodegradable Mg-based implants for clinical applications.

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Section: Resultsmentioning

confidence: 99%

Effect of the Combination of Torsional and Tensile Stress on Corrosion Behaviors of Biodegradable WE43 Alloy in Simulated Body Fluid

Wang

Gao

Pan³

et al. 2023

JFB

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“…However, after summarizing the relevant literature, we found that the definition of pore size is not clear in some literature sources. Furthermore, no unified positioning and measurement methods are available ( Yavari et al, 2013 ; Amin Yavari et al, 2014 ; Soro et al, 2019 ; Liu et al, 2022 ). This problem has prompted some studies to cite findings from other literature with significant differences in the definition, localization, and measurement of pore size, leading to questioning the conclusions in their papers ( Zadpoor, 2015 ; Dziaduszewska and Zielinski, 2021 ).…”

Section: Current Problemsmentioning

confidence: 99%

Definition, measurement, and function of pore structure dimensions of bioengineered porous bone tissue materials based on additive manufacturing: A review

Wen

Liu

Wang

2023

Front. Bioeng. Biotechnol.

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Bioengineered porous bone tissue materials based on additive manufacturing technology have gradually become a research hotspot in bone tissue-related bioengineering. Research on structural design, preparation and processing processes, and performance optimization has been carried out for this material, and further industrial translation and clinical applications have been implemented. However, based on previous studies, there is controversy in the academic community about characterizing the pore structure dimensions of porous materials, with problems in the definition logic and measurement method for specific parameters. In addition, there are significant differences in the specific morphological and functional concepts for the pore structure due to differences in defining the dimensional characterization parameters of the pore structure, leading to some conflicts in perceptions and discussions among researchers. To further clarify the definitions, measurements, and dimensional parameters of porous structures in bioengineered bone materials, this literature review analyzes different dimensional characterization parameters of pore structures of porous materials to provide a theoretical basis for unified definitions and the standardized use of parameters.

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“…WE43 porous scaffolds were fabricated through laser powder bed fusion by Liu et al [ 85 ]. For in vivo tests, they used 45 6-month-old male New Zealand white rabbits with weights between 3 and 3.5 kg.…”

Section: In Vivo Behavior Of the Magnesium-based Scaffoldsmentioning

confidence: 99%

Additive Manufactured Magnesium-Based Scaffolds for Tissue Engineering

et al. 2022

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Additive manufacturing (AM) is an important technology that led to a high evolution in the manufacture of personalized implants adapted to the anatomical requirements of patients. Due to a worldwide graft shortage, synthetic scaffolds must be developed. Regarding this aspect, biodegradable materials such as magnesium and its alloys are a possible solution because the second surgery for implant removal is eliminated. Magnesium (Mg) exhibits mechanical properties, which are similar to human bone, biodegradability in human fluids, high biocompatibility, and increased ability to stimulate new bone formation. A current research trend consists of Mg-based scaffold design and manufacture using AM technologies. This review presents the importance of biodegradable implants in treating bone defects, the most used AM methods to produce Mg scaffolds based on powder metallurgy, AM-manufactured implants properties, and in vitro and in vivo analysis. Scaffold properties such as biodegradation, densification, mechanical properties, microstructure, and biocompatibility are presented with examples extracted from the recent literature. The challenges for AM-produced Mg implants by taking into account the available literature are also discussed.

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Biodegradable magnesium alloy WE43 porous scaffolds fabricated by laser powder bed fusion for orthopedic applications: Process optimization, in vitro and in vivo investigation

Cited by 52 publications

References 68 publications

Effect of the Combination of Torsional and Tensile Stress on Corrosion Behaviors of Biodegradable WE43 Alloy in Simulated Body Fluid

Effect of the Combination of Torsional and Tensile Stress on Corrosion Behaviors of Biodegradable WE43 Alloy in Simulated Body Fluid

Definition, measurement, and function of pore structure dimensions of bioengineered porous bone tissue materials based on additive manufacturing: A review

Additive Manufactured Magnesium-Based Scaffolds for Tissue Engineering

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