Biodegradable Liposomes for Acyclovir-Gold Nanoparticles as an Efficient Carrierfor Enhanced Topical Delivery

Abstract

Objective: Gold nanoparticles and nanoliposomes are effective new technology in delivering the bioactive agents and enhancing their performance by increasing the bioavailability. The goal of the present study was the formulation of liposome for the use as a carrier for nanogold conjugated with acyclovir (ACV), an antiviral drug, to enhance ACV delivery. Methods:The gold nanoparticles were used as a capping agent for ACV and sodium citrate was used as reducing agent for the gold. Transmission electron microscopy was used for characterization and to study the morphological and structural properties of drug-metallic nanostructures. Nanoliposomes were formulated using different molar ratios of a positive charge inducer (stearyl amine) or a negative charge inducer (diacetyl phosphate), lecithin, cholesterol and Span 60.Results: Gold nanoparticles with a particle size of 10-20 nm were formed. This small size of the formed particles has a clear effect in reducing the gold nanoparticles toxicity and enhancing the cellular uptake. The amount of sodium citrate used in this preparation influences the size of the gold nanoparticle. The present study employed 1% trisodium citrate that contains a carboxylic group and this carboxylic group works as a reducing and capping agent to synthesize ACV-gold nanoparticles conjugate. Liposomal formula F6 had the highest entrapment efficiency approaching 42%, the low particle size of 160 nm, and zeta potential of 43.5 mV. Conclusion:It is evident from the study that the liposomes can be used as a carrier of ACV conjugated with gold nanoparticles. This new strategy could be used successfully in the treatment of viral infection.

68Ga‐labeled, imatinib encapsulated, theranostic liposomes: Formulation, characterization, and in vitro evaluation of anticancer activity

“…Many parameters such as the type and rate of lipid composition in the formulation, or properties of the drug affect the drug release profile in liposomes. The slowest acyclovir release was obtained from liposomes comprising SA among different formulations including anionic or neutral ones (Salem et al, 2017). Therefore, in our findings, the reason for slower IMT release from Cat‐Lipo/IMT maybe SA.…”

3d Printing: A Review on the Transformation of Additive Manufacturing

“…Within 3D printed nanocomposites, there is a nano-biointerface and it has an impact on cell-extracellular Metrix interactions. In vitro tissue/organ models made from Scaffolds with 3D printed nanostructures could be used to research disease progression and drug discovery [120].…”

the THE EFFECT OF CHITOSAN COATING ON MAFENIDE ACETATE-LOADED LIPOSOME CHARACTERIZATION AND DELIVERY THROUGH BURNED RAT SKIN

“…To promote drug localization, it is necessary to design a new drug delivery system for increasing drug trapping into the wound. Reduction in systemic absorption by topical liposomal administration has been reported [7]. Liposomes contain phospholipids and cholesterol and are useful vehicles for many hydrophilic and hydrophobic drugs due to their amphipathic identities [7].…”

“…Reduction in systemic absorption by topical liposomal administration has been reported [7]. Liposomes contain phospholipids and cholesterol and are useful vehicles for many hydrophilic and hydrophobic drugs due to their amphipathic identities [7]. Therefore, liposome was selected for mafenide acetate delivery through burned rat skin.…”