Biodegradable Inorganic Nanovector: Passive versus Active Tumor Targeting in siRNA Transportation

Park, Dae-Hwan; Cho, Jaeyong; Kwon, Oh-Joon; Yun, Chae‐Ok

doi:10.1002/ange.201510844

Cited by 25 publications

(29 citation statements)

References 40 publications

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“…Selective tumor targeting and siRNAbased mRNA degradation in vitro and in vivo [119] MgAl Ovalbumin (antigen) and CpG (ligand)…”

Section: Discussionmentioning

confidence: 99%

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Bio-Layered Double Hydroxides Nanohybrids for Theranostics Applications

Park

Choi

2015

Structure and Bonding

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“…Selective tumor targeting and siRNAbased mRNA degradation in vitro and in vivo [119] MgAl Ovalbumin (antigen) and CpG (ligand)…”

Section: Discussionmentioning

confidence: 99%

“…Currently, Choy's group is exploring theranostic siRNA-LDH nanohybrids system for targeted cancer therapy and imaging function (Fig. 17) [119]. Two groups of siRNA-LDH nanohybrids were developed for the in vivo delivery of siRNA with advanced cancer treatment.…”

Section: Gene-ldh Theranostics In Vitro and In Vivomentioning

confidence: 99%

Bio-Layered Double Hydroxides Nanohybrids for Theranostics Applications

Park

Choi

2015

Structure and Bonding

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“…The accumulation of TiS 2 -HSA-FA in tumor was likely due to the FA modification, which is known to facilitate tumor targeting. 44,45 As shown in Figure 5C, after intravenous injection, blood distribution half-life (t 1/2 α) and blood terminal elimination half-life (t 1/2 β) of the TiS 2 -HSA-FA were 1.21±0.11 hrs and 17.52±0.62 hrs, respectively. It has been reported that PEG and HSA modifications can prolong blood circulation and reduce macrophage clearance of nanoparticles from the reticuloendothelial system.…”

Section: In Vivo Biodistribution and Blood Circulationmentioning

confidence: 94%

<p>Albumin exfoliated titanium disulfide nanosheet: a multifunctional nanoplatform for synergistic photothermal/radiation colon cancer therapy</p>

Cao¹,

Zhang²,

Yang³

et al. 2019

OTT

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Purpose: TiS 2-HSA-FA, a nanoagent based on titanium disulfide (TiS 2), human serum albumin (HSA), and folic acid (FA), was synthesized for potential use in synergistic photothermal/radiation therapy for colon cancer. Methods: TiS 2 nanosheets were synthesized through a HSA-assisted exfoliation method and then modified with PEGylated FA. The morphology, size, zeta potential, stability, cellular uptake, cytotoxicity, biodistribution, and in vitro and in vivo biocompatibility of the nanoparticles as well as their suitability for synergistic photothermal/radiation colon cancer therapy were investigated. Results: The as-synthesized TiS 2-HSA-FA nanoparticles showed excellent physiological stability, as well as high absorption values in the near-infrared (NIR) and X-ray regions, giving them superb activity as a photothermal and radiation sensitizer. In vitro and in vivo experiments indicated that TiS 2-HSA-FA showed high tumor targeting selectivity, blood circulation time, biocompatibility, and suitability for synergistic tumor photothermal radiotherapy. Conclusion: A multifunctional nanoplatform based on TiS 2 was developed and found to be potentially suitable for synergistic photothermal/radiation therapy for colon cancer.

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“…Recent progress in ceramic nanosystems has led to innovations in fields combining biomedicine, energy, the environment, and even information technology. [3][4][5][6][7][8][9] In recent decades, globalization has evolved at an exponential pace due to the digital revolution and rapid advances in various technologies that have led to an increase in the quantity of digital information. 10) As a result, the requirement of a code system has emerged that can carry a high density of information and allows reliability, integrity, authenticity, and confidentiality in data processing.…”

Section: Introductionmentioning

confidence: 99%

Info-Convergence Ceramic Nanosystems

Jin¹,

Park²

2019

J. Korean Ceram. Soc

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We face many fascinating and diverse challenges, the most important among which is to determine how to store a large amount of information with novel approaches. Info-convergence ceramic nanosystems, which combine ceramic materials science and information technology, may provide an attractive alternative. This review considers recent multidisciplinary advances in the development of info-convergence nanosystems based on ceramic materials and discusses various strategies under ceramic-based information systems with a special focus on materials and nanohybridization technologies. Ceramic materials have played diverse roles not only as the generic coding support, but also as the central coding substance. The review highlights the ceramic nanohybrid bio code and ceramic nanoparticle optical code for applications in tracking-and-traceability management, nano-forensics, anticounterfeiting, and even communication, as well as the four steps of encoding, encrypting, decrypting, and decoding for the desired applications. Additionally, associated challenges, potential solutions, and perspectives for future developments in the field are discussed.

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Biodegradable Inorganic Nanovector: Passive versus Active Tumor Targeting in siRNA Transportation

Abstract: Seoul 133-791 (Republic of Korea) Supportinginformation for this article can be found under http://dx.

Cited by 25 publications

References 40 publications

Bio-Layered Double Hydroxides Nanohybrids for Theranostics Applications

Bio-Layered Double Hydroxides Nanohybrids for Theranostics Applications

<p>Albumin exfoliated titanium disulfide nanosheet: a multifunctional nanoplatform for synergistic photothermal/radiation colon cancer therapy</p>

Info-Convergence Ceramic Nanosystems

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