Biodegradable Gold Nanovesicles with an Ultrastrong Plasmonic Coupling Effect for Photoacoustic Imaging and Photothermal Therapy

Abstract

Hierarchical assembling of gold nanoparticles (GNPs) allows one to engineer the localized surface plasmon resonance (LSPR) peaks to the near-infrared (NIR) region for enhanced photothermal Therapy (PTT). Herein we report a novel theranostic platform based on biodegradable plasmonic gold nanovesicles for photoacoustic (PA) Imaging and PTT. The disulfide bond (S-S) termed PEG-b-PCL block copolymer graft allows dense packing of GNPs during the assembly process and induces ultra-strong plasmonic coupling effect between adjacent GNPs. The strong NIR absorption induced by plasmon coupling and very high photothermal conversion efficiency (η= 37 %) enable simultaneous thermal/PA imaging and enhanced PTT efficacy with improved clearance of the dissociated particles after the completion of PTT. These vesicle-architectures assembling of various nanocrystals with tailored optical, magnetic, and electronic properties opens new possibilities for constructing multifunctional biodegradable platforms for biomedical applications, particularly in cancer theranotics.

Fullerene/photosensitizer nanovesicles as highly efficient and clearable phototheranostics with enhanced tumor accumulation for cancer therapy

“…[44][45][46][47][48][49][50][51] However, so far there is no report about the nanovesicles based on amphiphilic fullerene derivatives for phototheranostics application. Therefore, it is of great interest to develop nanovesicles based on fullerene derivatives/PS and explore their cancer therapy efficiency as novel phototheranostic agents.…”

Plasmonic, Targeted, and Dual Drugs-Loaded Polypeptide Composite Nanoparticles for Synergistic Cocktail Chemotherapy with Photothermal Therapy

“…21-31 To enhance therapeutic effect of single photothermal therapy, researchers have made great efforts on the preparation of plasmonic polymeric gold composite nanoparticles and their applications for the combination chemo-photothermal therapy. [23][24][25][26][27][31][32][33][34] Organic photothermal agent of indocyanine green and DOX co-loaded nanoparticles presented good chemo-photothermal effect on cancer cells. [35][36][37] However, the studies on multifunctional anticancer nanotherapeutics with synergistic combination of photothermal therapy and cocktail chemotherapy are scarcely reported.…”

Entropy-Driven Hierarchical Nanostructures from Cooperative Self-Assembly of Gold Nanoparticles/Block Copolymers under Three-Dimensional Confinement

“…28,29 Although the inorganic NPs have been successfully encapsulated into BCP microdomain, it is still a big challenge to precise control the spatial arrangement of NPs in the polymer matrix. Basically, both enthalpic and entropic interactions are involved during the incorporation of NPs into the polymer matrix.…”