Biodegradable gelatin–ciprofloxacin–montmorillonite composite hydrogels for controlled drug release and wound dressing application

Kevadiya, Bhavesh D.; Rajkumar, Shalini; Bajaj, Hari C.; Chettiar, Shiva Shankaran; Gosai, Kalpeshgiri; Brahmbhatt, Harshad; Bhatt, Adarsh S.; Barvaliya, Yogesh K.; Dave, Gaurav S.; Kothari, Ramesh

doi:10.1016/j.colsurfb.2014.06.051

Cited by 119 publications

(47 citation statements)

References 50 publications

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“…Surface morphology of blank samples (M 4 –M 6 ) noticeably illustrates that cross‐linking creates open porous structures containing irregular pores throughout the matrix . In addition, compared with the blank samples, incorporating CIP into interspace of fibers enlarges their morphology (CIP‐M 10 –M 12 ) in a state of swelling, especially in the CIP‐M 11 membrane, which seems that fibers are attached to each other …”

Section: Resultsmentioning

confidence: 93%

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Evaluation of sustained ciprofloxacin release of biodegradable electrospun gelatin/poly(glycerol sebacate) mat membranes for wound dressing applications

Najafabadi

Shirazaki

Kharazi

et al. 2018

Asia-Pacific J Chem Eng

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In this research, gelatin and poly(glycerol sebacate) (PGS), which have demonstrated significantly developed wound healing process, were used to fabricate biodegradable and bioabsorbable membranes with controlled release of ciprofloxacin (CIP) as a powerful antibiotic. This was achieved by taking advantage of electrospinning technique to accelerate the wound healing as an extracellular matrix-liked composite membrane. We attempted to carefully investigate the impact of variable ratio of sebacic acid and glycerol as components of PGS and identified CIP-loaded cross-linked membrane (CIP-M 11 ) as an optimum membrane, although a significant change in structural properties of samples was not observed. The physicochemical properties of drug-loaded electrospun wound cover were evaluated by several characterization tests.Scanning electron microscopy and Fourier transform infrared spectroscopy results confirmed that CIP-embedded gelatin/PGS membrane was successfully synthesized and cross-linked properly. The CIP-M 11 sample showed a constant and uniform degradation rate with the capacity of durable drug release over the time period. The excellent antibacterial activity of CIP decreased the population of both Escherichia coli and Staphylococcus aureus bacteria and prevented bacterial infections. The cytocompatibility of membranes was completely proven by culturing L929 fibroblast cells on the prepared membranes. Finally, obtained results exhibit that the membranes should be considered as the promising wound dressing.

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Section: Resultsmentioning

confidence: 93%

“…C–H stretching band can be detected at peaks 2,932 and 2,857 cm −1 , with the peak at 3,067 cm −1 corresponding to carboxylic (COOH) groups. Notably, the C–F group of CIP shows a strong peak at 1,050 cm −1 , which confirm the presence of CIP in the cross‐linked electrospun membranes …”

Section: Resultsmentioning

confidence: 95%

Evaluation of sustained ciprofloxacin release of biodegradable electrospun gelatin/poly(glycerol sebacate) mat membranes for wound dressing applications

Najafabadi

Shirazaki

Kharazi

et al. 2018

Asia-Pacific J Chem Eng

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“…In addition, the characteristic of ion-exchange reactions and the existence of electrostatic interactions between the intercalated drug and the alkali metal ions of the buffer were responsible for a relatively sustained slow release. 47 The drug release from simulation models showed that the in vitro drug-release profiles of Mt-BH-LPs were consistent with both the Weibull equation (r =0.9988) and the firstorder kinetics equation (r =0.9913). These indicated that BH release was controlled by diffusion, as well as matrix-erosion mechanisms from Mt-BH-LPs at a suitable rate.…”

Section: In Vitro Release Studiesmentioning

confidence: 61%

A novel ion-exchange carrier based upon liposome-encapsulated montmorillonite for ophthalmic delivery of betaxolol hydrochloride

Huang¹,

Qi²,

Hou³

et al. 2017

IJN

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As a novel ion-exchange carrier with high surface area and excellent exchangeability, montmorillonite (Mt) was intercalated with betaxolol hydrochloride (BH) to form a nanocomposite and then encapsulated by liposomes (Mt-BH-LPs) for an ophthalmic drug-delivery system. The Mt-BH and Mt-BH-LPs were prepared by an acidification process and ethanol injection combined with ammonium sulfate gradient methods. The successful formation of Mt-BH and Mt-BH-LPs was verified by thermogravimetric analysis, X-ray diffraction, Fourier-transform infrared spectra, and transmission electron microscopy. Mt-BH-LPs possessed the favorable physical characteristics of encapsulation efficiency, drug loading, mean particle size, and ζ-potential. In vitro release studies indicated Mt-BH-LPs effectively maintained a relatively sustained slow release. Immortalized human corneal epithelial cell cytotoxicity, in vivo rabbit eye-irritation tests, and chorioallantoic membrane–trypan blue staining all revealed that Mt-BH-LPs had no obvious irritation on ocular tissues. A new in vitro tear-turnover model, including inserts containing human corneal epithelial cells, was designed to evaluate the precorneal retention time of Mt-BH-LPs. The results showed that Mt-BH-LPs maintained a certain BH concentration in tear fluid for a longer period than the BH solution. In vivo precorneal retention studies also indicated Mt-BH-LPs prolonged drug retention on the ocular surface more than the BH solution. Furthermore, pharmacodynamic studies showed that Mt-BH-LPs had a prolonged effect on decreasing intraocular optical pressure in rabbits. Our results demonstrated that Mt-BH-LPs have potential as an ophthalmic delivery system.

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“…Naturally abundant montmorillonite (MMT) is a smectite group of clay without any toxicity . Kevadiya et al . developed a Ge–ciprofloxacin–MMT composite hydrogel demonstrating the controlled release of drugs up to 150 h and application in wound dressing.…”

Section: Introductionmentioning

confidence: 99%

Development of a gelatin‐g‐poly(acrylic acid‐co‐acrylamide)–montmorillonite superabsorbent hydrogels forin vitrocontrolled release of vitamin B₁₂

Nath¹,

Chowdhury²,

Ali³

et al. 2019

J of Applied Polymer Sci

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Gelatin (Ge)‐g‐poly(acrylic acid‐co‐acrylamide) and montmorillonite (MMT)‐clay‐based nanocomposite hydrogels were fabricated to study the controlled release of vitamin B12. Polymeric hydrogels were characterized with Fourier transform infrared (FTIR) spectroscopy, X‐ray diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). FTIR spectroscopy confirmed the grafting of partially neutralized acrylic acid on a Ge backbone. The incorporation of MMT fillers inside the nanocomposite hydrogels and their increased crystallinity were established by XRD analysis. The rough surface morphologies of the composite hydrogels shown by SEM resulted from the assimilation of MMT inside the same. TEM confirmed the formation of nanosized composites. The average length and width of the MMT platelets were found to be 184.37 and 20.48 nm, respectively. The maximum swelling of the hydrogel was 375 g/g, and the results were established with Design‐Expert software. The biodegradability of the nanocomposite increased in comparison to that of the copolymer hydrogel. Biocompatibility and cytotoxicity studies were also performed. During different time intervals, the controlled release of vitamin B12 in artificial gastric fluid (AGF) and artificial intestinal fluid (AIF) was evaluated with a UV–visible spectrophotometer; this resulted in different controlled release curves. The release in AGF was 42%, and in AIF, the cumulative release was 80% over 6 h. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47596.

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Biodegradable gelatin–ciprofloxacin–montmorillonite composite hydrogels for controlled drug release and wound dressing application

Cited by 119 publications

References 50 publications

Evaluation of sustained ciprofloxacin release of biodegradable electrospun gelatin/poly(glycerol sebacate) mat membranes for wound dressing applications

Evaluation of sustained ciprofloxacin release of biodegradable electrospun gelatin/poly(glycerol sebacate) mat membranes for wound dressing applications

A novel ion-exchange carrier based upon liposome-encapsulated montmorillonite for ophthalmic delivery of betaxolol hydrochloride

Development of a gelatin‐g‐poly(acrylic acid‐co‐acrylamide)–montmorillonite superabsorbent hydrogels forin vitrocontrolled release of vitamin B₁₂

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Biodegradable gelatin–ciprofloxacin–montmorillonite composite hydrogels for controlled drug release and wound dressing application

Cited by 119 publications

References 50 publications

Evaluation of sustained ciprofloxacin release of biodegradable electrospun gelatin/poly(glycerol sebacate) mat membranes for wound dressing applications

Evaluation of sustained ciprofloxacin release of biodegradable electrospun gelatin/poly(glycerol sebacate) mat membranes for wound dressing applications

A novel ion-exchange carrier based upon liposome-encapsulated montmorillonite for ophthalmic delivery of betaxolol hydrochloride

Development of a gelatin‐g‐poly(acrylic acid‐co‐acrylamide)–montmorillonite superabsorbent hydrogels forin vitrocontrolled release of vitamin B12

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Development of a gelatin‐g‐poly(acrylic acid‐co‐acrylamide)–montmorillonite superabsorbent hydrogels forin vitrocontrolled release of vitamin B₁₂