Biodegradable Core-shell Dual-Metal-Organic-Frameworks Nanotheranostic Agent for Multiple Imaging Guided Combination Cancer Therapy

Abstract

Metal-organic-frameworks (MOFs) possess high porosity, large surface area, and tunable functionality are promising candidates for synchronous diagnosis and therapy in cancer treatment. Although large number of MOFs has been discovered, conventional MOF-based nanoplatforms are mainly limited to the sole MOF source with sole functionality. In this study, surfactant modified Prussian blue (PB) core coated by compact ZIF-8 shell (core-shell dual-MOFs, CSD-MOFs) has been reported through a versatile stepwise approach. With Prussian blue as core, CSD-MOFs are able to serve as both magnetic resonance imaging (MRI) and fluorescence optical imaging (FOI) agents. We show that CSD-MOFs crystals loading the anticancer drug doxorubicin (DOX) are efficient pH and near-infrared (NIR) dual-stimuli responsive drug delivery vehicles. After the degradation of ZIF-8, simultaneous NIR irradiation to the inner PB MOFs continuously generate heat that kill cancer cells. Their efficacy on HeLa cancer cell lines is higher compared with the respective single treatment modality, achieving synergistic chemo-thermal therapy efficacy. In vivo results indicate that the anti-tumor efficacy of CSD-MOFs@DOX+NIR was 7.16 and 5.07 times enhanced compared to single chemo-therapy and single thermal-therapy respectively. Our strategy opens new possibilities to construct multifunctional theranostic systems through integration of two different MOFs.

ZnS@ZIF-8 core-shell nanoparticles incorporated with ICG and TPZ to enable H2S-amplified synergistic therapy

“…ZnS nanoparticles were then surface-modified with PSS molecules to attract Zn 2+ ions, favoring the nucleation and growth of ZIF-8 shell at its surface. PVP may act as the stabilizer to prevent agglomeration and facilitates the formation of ZIF-8 shell 37 , 40 , 41 . As shown in Figure 2 B, the ZIF-8 shell, with a thickness of ~25 nm, is formed at the surface of ZnS cores.…”

“…After 6 h stirring, nanoparticles were collected by centrifugation and washed with methanol for three times. Then, ZnS@ZIF-8/ICG (ZSZI) was dispersed in deionized water for subsequent TPZ loading 37 . Briefly, 5 mg TPZ was added into above aqueous solution and stirred for another 10 h. After centrifugation, the samples were collected and washed for further use.…”

Biodegradable Metal–Organic Framework‐Based Microrobots (MOFBOTs)

“…The morphology and elemental distribution of the particles were investigated with scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDX), respectively. As shown in Figure 2a, while Fe@ZIF-8 crystals clearly have the typical dodecahedral shape of ZIF-8 ( Figure S1a, Supporting Information), their size distribution is larger than ZIF-8 crystals with values of 900 ± 300 nm (Figure S1c,d,Supporting Information). This variation in the particle size indicates that adding iron to the reaction media influences the crystallization mechanism, which results in a broader range of particle sizes.…”

Ultrathin Cu-TCPP MOF nanosheets: a new theragnostic nanoplatform with magnetic resonance/near-infrared thermal imaging for synergistic phototherapy of cancers

“…As newly emerging porous materials, metal-organic frameworks (MOFs), constructed by the combination of metal ions or clusters with polytopic organic ligands, have drawn extensive attention as potential candidates for catalysts, sensors, gas separators, and biomedicines 1 , 2 . Especially, MOFs show great potential in phototherapy of cancer cells due to their intrinsic biodegradability, high porosity, structural/chemical diversity, and highly enriched functionality 3 - 7 .…”