Biodegradable Contrast Agents for Photoacoustic Imaging

Yoo, Su Woong; Jung, Doyoung; Min, Jung‐Joon; Kim, Hyungwoo; Lee, Changho

doi:10.3390/app8091567

Cited by 22 publications

(18 citation statements)

References 86 publications

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“…8 Additionally, to delineate transparent organs such as lymph nodes, gastrointestinal tracts, and bladders, labeled imaging has also been performed using several contrast agents, such as indocyanine green or methylene blue. [9][10][11][12] The second window of the NIR (NIR-II) region, also called short-wave infrared region (SWIR, defined here as 1100 to 2000 nm), is of current interest due to the relative low levels of scattering and the high-maximum permissible exposure compared with the NIR-I region. [12][13][14][15] Additionally, in the SWIR band, we find the optical absorption peaks of water, collagen, and lipids, three major molecules of human tissues.…”

Section: Introductionmentioning

confidence: 99%

Effective photoacoustic absorption spectrum for collagen-based tissue imaging

Park

Lee

et al. 2020

J. Biomed. Opt.

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Significance: Collagen is a basic component of many tissues such as tendons, muscles, and skin, and its imaging helps diagnose and monitor treatments in a variety of fields, including orthopedics. However, due to the overlapping peaks of the absorption spectrum with water in the shortwave infrared region (SWIR), it is difficult to select an optimal wavelength and obtain the photoacoustic (PA) image for collagen-based tissues. Therefore, an additional approach to selecting the proper wavelength is needed. Aim: The aim of this study is to derive an effective PA absorption spectrum of collagen to select the optimal wavelength for high-sensitive PA imaging (PAI). Approach: We measure the absorption spectrum by acquiring the PA signal from various collagen-based samples. To derive an effective PA absorption spectrum in the SWIR band, the following two parameters should be considered: (1) the laser excitation for generating the PA signal and (2) the absorption spectrum for water in the SWIR band. This molecular intrinsic property suggests the optimal wavelength for high-sensitive PAI of collagen-based samples. Results: PA absorption spectral peaks of collagen were found at wavelengths of 1200, 1550, and 1700 nm. Thereby, the PA signal increased by up to five times compared with the wavelength commonly used in collagen PAI. We applied a pulsed fiber laser with a center wavelength of 1560 nm, and the three-dimensional PA image of a collagen patch was obtained. Conclusions: The effective PA absorption spectrum contributes to the improvement of the PA image sensitivity by presenting the optimal wavelength of the target samples.

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Section: Introductionmentioning

confidence: 99%

Effective photoacoustic absorption spectrum for collagen-based tissue imaging

Park

Lee

et al. 2020

J. Biomed. Opt.

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“…In addition to the ICG-based PA imaging shown here, many other types of promising nanoparticles could also be used as contrast agents for in vivo PA imaging [37][38][39][40][41][42][43]. For example, gold nanoparticles (e.g., nanorods and nanocages), single-walled carbon nanotubes (SWNTs) and quantum dots (QDs) can all be detected using PA imaging [39,40]. ICG itself can also be encapsulated in different nanoparticle formulations for specific imaging applications [41].…”

Section: Discussionmentioning

confidence: 99%

Characterization of a Fiber Bundle-Based Real-Time Ultrasound/Photoacoustic Imaging System and Its In Vivo Functional Imaging Applications

Wang

Jhang

et al. 2019

Micromachines

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Photoacoustic (PA) imaging is an attractive technology for imaging biological tissues because it can capture both functional and structural information with satisfactory spatial resolution. Current commercially available PA imaging systems are limited by their bulky size or inflexible user interface. We present a new handheld real-time ultrasound/photoacoustic imaging system (HARP) consisting of a detachable, high-numerical-aperture (NA) fiber bundle-based illumination system integrated with an array-based ultrasound (US) transducer and a data acquisition platform. In this system, different PA probes can be used for different imaging applications by switching the transducers and the corresponding jackets to combine the fiber pads and transducer into a single probe. The intuitive user interface is a completely programmable MATLAB-based platform. In vitro phantom experiments were conducted to test the imaging performance of the developed PA system. Furthermore, we demonstrated (1) in vivo brain vasculature imaging, (2) in vivo imaging of real-time stimulus-evoked cortical hemodynamic changes during forepaw electrical stimulation, and (3) in vivo imaging of real-time cerebral pharmacokinetics in rats using the developed PA system. The overall purpose of this design concept for a customizable US/PA imaging system is to help overcome the diverse challenges faced by medical researchers performing both preclinical and clinical PA studies.

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“…Polymer encapsulation is often used for small molecular dyes, which often consist of huge and conjugated hydrocarbon systems that are hydrophobic; thus, insoluble in water. Therefore, a polymer capsule is added to grant water solubility and surface for functionalization [ 43 , 70 , 71 ].…”

Section: Exogenous Contrast Agentsmentioning

confidence: 99%

A Review of Endogenous and Exogenous Contrast Agents Used in Photoacoustic Tomography with Different Sensing Configurations

Tsang

Wong

2020

Sensors

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Optical-based sensing approaches have long been an indispensable way to detect molecules in biological tissues for various biomedical research and applications. The advancement in optical microscopy is one of the main drivers for discoveries and innovations in both life science and biomedical imaging. However, the shallow imaging depth due to the use of ballistic photons fundamentally limits optical imaging approaches’ translational potential to a clinical setting. Photoacoustic (PA) tomography (PAT) is a rapidly growing hybrid imaging modality that is capable of acoustically detecting optical contrast. PAT uniquely enjoys high-resolution deep-tissue imaging owing to the utilization of diffused photons. The exploration of endogenous contrast agents and the development of exogenous contrast agents further improve the molecular specificity for PAT. PAT’s versatile design and non-invasive nature have proven its great potential as a biomedical imaging tool for a multitude of biomedical applications. In this review, representative endogenous and exogenous PA contrast agents will be introduced alongside common PAT system configurations, including the latest advances of all-optical acoustic sensing techniques.

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Biodegradable Contrast Agents for Photoacoustic Imaging

Cited by 22 publications

References 86 publications

Effective photoacoustic absorption spectrum for collagen-based tissue imaging

Effective photoacoustic absorption spectrum for collagen-based tissue imaging

Characterization of a Fiber Bundle-Based Real-Time Ultrasound/Photoacoustic Imaging System and Its In Vivo Functional Imaging Applications

A Review of Endogenous and Exogenous Contrast Agents Used in Photoacoustic Tomography with Different Sensing Configurations

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