Biodegradable and redox-responsive chitosan/poly(l-aspartic acid) submicron capsules for transmucosal delivery of proteins and peptides

Zheng, Chao; Zhang, X. G.; Sun, Lei; Zhang, Z. P.; Li, C. X.

doi:10.1007/s10856-013-4863-z

Cited by 37 publications

(18 citation statements)

References 29 publications

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“…Zheng et al designed and synthesized biodegradable redox-responsive nanocapsules adopting the layer-by-layer technique with poly (L-aspartic acid) and chitosan as vehicles for transmucosal delivery of proteins and peptides [51]. TEM images showed that intact nanocapsules were obtained and the shell of the nanocapsules was about 40 nm.…”

Section: Physiological Stimuli-triggered Deliverymentioning

confidence: 99%

Stimuli-responsive nanomaterials for therapeutic protein delivery

Lü

Sun

2014

Journal of Controlled Release

372

285

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Protein therapeutics have emerged as a significant role in treatment of a broad spectrum of diseases, including cancer, metabolic disorders and autoimmune diseases. The efficacy of protein therapeutics, however, is limited by their instability, immunogenicity and short half-life. In order to overcome these barriers, tremendous efforts have recently been made in developing controlled protein delivery systems. Stimuli-triggered release is an appealing and promising approach for protein delivery and has made protein delivery with both spatiotemporal- and dosage-controlled manners possible. This review surveys recent advances in controlled protein delivery of proteins or peptides using stimuli-responsive nanomaterials. Strategies utilizing both physiological and external stimuli are introduced and discussed.

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Section: Physiological Stimuli-triggered Deliverymentioning

confidence: 99%

Stimuli-responsive nanomaterials for therapeutic protein delivery

Lü

Sun

2014

Journal of Controlled Release

372

285

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“…Despite the intense study on capsule properties and their interaction with cells, there is a lack of reported data on how the capsules would behave if administered systemically in vivo. So far, there have been few reports on lbl capsules administered in vivo either via subcutaneous injection or nasal gavage [ 24 , 25 , 26 , 27 ]. There are attempts for MRI imaging of iron oxide modified capsules.…”

Section: Introductionmentioning

confidence: 99%

Systemic Administration of Polyelectrolyte Microcapsules: Where Do They Accumulate and When? In Vivo and Ex Vivo Study

et al. 2018

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Multilayer capsules of 4 microns in size made of biodegradable polymers and iron oxide magnetite nanoparticles have been injected intravenously into rats. The time-dependent microcapsule distribution in organs was investigated in vivo by magnetic resonance imaging (MRI) and ex vivo by histological examination (HE), atomic absorption spectroscopy (AAS) and electron spin resonance (ESR), as these methods provide information at different stages of microcapsule degradation. The following organs were collected: Kidney, liver, lung, and spleen through 15 min, 1 h, 4 h, 24 h, 14 days, and 30 days after intravenous injections (IVIs) of microcapsules in a saline buffer at a dosage of 2.5 × 109 capsule per kg. The IVI of microcapsules resulted in reversible morphological changes in most of the examined inner organs (kidney, heart, liver, and spleen). The capsules lost their integrity due to degradation over 24 h, and some traces of iron oxide nanoparticles were seen at 7 days in spleen and liver structure. The morphological structure of the tissues was completely restored one month after IVI of microcapsules. Comprehensive analysis of the biodistribution and degradation of entire capsules and magnetite nanoparticles as their components gave us grounds to recommend these composite microcapsules as useful and safe tools for drug delivery applications.

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“…Furthermore, neither the thiol content nor the redox state of the thiol groups was controlled. The synthesis of thiolated PASP through carbodiimide mediated reactions is expensive and requires a large excess of the carbodiimide mediator . Thus, we used a simple synthetic pathway to prepare thiolated PASP, developed earlier by Szilágyi and co‐workers .…”

Section: Introductionmentioning

confidence: 99%

Redox‐ and pH‐Responsive Nanogels Based on Thiolated Poly(aspartic acid)

Krisch

Messager

Ravaine

et al. 2015

Macro Materials & Eng

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Nanogels loaded with fluorescent dextran as a model drug are synthesized by the oxidation induced cross‐linking of water soluble redox responsive thiolated poly(amino acid) in miniemulsion without the introduction of any cross‐linker molecule. Two types of high energy methods, namely, ultrasonication and high pressure homogenization (HPH), are compared. Dynamic light scattering and transmission electron microscopy measurements confirm that spherical nanogels in 100–150 nm diameter range are prepared successfully by HPH method. Size and surface charge of the nanogels can easily be controlled by environmental pH. The release of encapsulated drug is triggered by the degradation of nanogels in reducing environment due to the cleavage of disulphide bonds.

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Biodegradable and redox-responsive chitosan/poly(l-aspartic acid) submicron capsules for transmucosal delivery of proteins and peptides

Cited by 37 publications

References 29 publications

Stimuli-responsive nanomaterials for therapeutic protein delivery

Stimuli-responsive nanomaterials for therapeutic protein delivery

Systemic Administration of Polyelectrolyte Microcapsules: Where Do They Accumulate and When? In Vivo and Ex Vivo Study

Redox‐ and pH‐Responsive Nanogels Based on Thiolated Poly(aspartic acid)

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