Bioconversion of vaccenic acid to conjugated linoleic acid in humans

Turpeinen, Anu M.; Mutanen, Marja; Aro, Antti; Salminen, Irma; Basu, Samar; Palmquist, D.L.; Griinari, J. M.

doi:10.1093/ajcn/76.3.504

Cited by 417 publications

(297 citation statements)

References 36 publications

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“…Recent studies [10] have found that most of the RA in ruminant milk fat is synthesized endogenously from 11-trans C18:1 by desaturases. Furthermore, TVA has also been found as an RA precursor in human tissues [28]. If this evidence were confirmed, remarkable benefits could be obtained from ewe's milk fat product consumption.…”

Section: Mutfa Content and Profilementioning

confidence: 86%

Quantitative characterization of unsaturated and trans fatty acids in ewe’s milk fat

Goudjil

Fontecha

Luna

et al. 2004

Lait

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-Ewe's milk fat obtained from the milk of five different herds were studied to characterize main and minor fatty acids using a combination of gas chromatography and mass spectrometry. In order to assess monounsatured trans fatty acids content, fatty acid methyl esters (FAME) were fractionated by silver ion thin-layer chromatography prior to gas chromatography analysis. Trans fatty acids (TFA), including conjugated linoleic acid, represented 4.9% of the total FAME; most of them belonged to C18:1 trans isomers (2.9%) with a small range of variation (2.5-3.2%). The distribution profile of trans-C18:1 molecules indicated that more than half were trans-11, whereas the proportion of potentially unhealthy compounds (trans-10 and trans-9 C18:1) was less than 10%. Mean trans-C16:1 content was 0.25% of total FAME. The sum of the different trans-C18:2 isomers (excluding conjugated linoleic acid) was 0.88% and C18:3 trans isomers represented 0.16%. Ewe's milk / fatty acid / trans fatty acidRésumé -Caractérisation quantitative des acides gras insaturés et trans de la matière grasse du lait de brebis. Les acides gras mineurs et majeurs du lait de brebis provenant de cinq troupeaux différents ont été caractérisés par chromatographie gazeuse associée à la spectrométrie de masse. En vue de connaître le contenu en acides gras monoinsaturés trans, les esters méthyliques des acides gras ont été fractionnés en recourant à la chromatographie sur couche mince à l'ion argent suivie d'une analyse par chromatographie gazeuse. Les acides gras trans, incluant l'acide linoléique conjugué, représentaient 4,9 % du total des esters méthyliques des acides gras. La plupart d'entre eux appartenaient aux isomères trans du C18:1 (2,9 %) avec une variation faible entre les échantillons (2,5-3,2 %). Le profil de distribution des molécules C18:1 trans montraient que plus de la moitié étaient des trans-11, tandis que les proportions de trans-10 et trans-9, potentiellement nuisibles à la santé, étaient inférieures à 10 %. La teneur moyenne en C16 :1 trans était de l'ordre de 0,25 % du total des esters méthyliques des acides gras. Le total des différents isomères C18:2 trans (à l'exception de l'acide linoléique conjugué) et C18:3 représentait respectivement 0,88 % et 0,16 % du total.

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Section: Mutfa Content and Profilementioning

confidence: 86%

Quantitative characterization of unsaturated and trans fatty acids in ewe’s milk fat

Goudjil

Fontecha

Luna

et al. 2004

Lait

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“…The observed increase in the content of trans-18:1 isomers when supplementing with oils rich in oleic acid could be due to the fact that oleic acid can interfere with the biohydrogenation of linoleic acid, leading to an accumulation of trans-18:1 (Mosley et al, 2002). Due to the ability of Δ 9 desaturase in human tissue to transform t 11-18:1 into c 9,t 11-18:2 (Turpeinen et al, 2002), the increase in the t 11-18:1 content in meat implies an improvement of its lipid profile.…”

Section: Meat Qualitymentioning

confidence: 99%

Animal performance and meat characteristics in steers reared in intensive conditions fed with different vegetable oils

Castro

Cabezas

Fuente

et al. 2016

Animal

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Enhancing the quality of beef meat is an important goal in terms of improving both the nutritional value for the consumer and the commercial value for producers. The aim of this work was to study the effects of different vegetable oil supplements on growth performance, carcass quality and meat quality in beef steers reared under intensive conditions. A total of 240 Blonde D' Aquitaine steers (average BW = 293.7 ± 38.88 kg) were grouped into 24 batches (10 steers/batch) and were randomly assigned to one of the three dietary treatments (eight batches per treatment), each supplemented with either 4% hydrogenated palm oil (PALM) or fatty acids (FAs) from olive oil (OLI) or soybean oil (SOY). No differences in growth performance or carcass quality were observed. For the meat quality analysis, a steer was randomly selected from each batch and the 6th rib on the left half of the carcass was dissected. PALM meat had the highest percentage of 16:0 ( P < 0.05) and the lowest n-6/n-3 polyunsaturated fatty acids (PUFA) ratio ( P < 0.05), OLI had the highest content of t 11-18:1 ( P < 0.01) and c 9,t 11-18:2 ( P < 0.05) and SOY showed the lowest value of monounsaturated fatty acids (MUFA) ( P < 0.001), the highest percentage of PUFA ( P < 0.01) and a lower index of atherogenicity ( P = 0.07) than PALM. No significant differences in the sensory characteristics of the meat were noted. However, the results of the principal component analysis of meat characteristics enabled meat from those steers that consumed fatty acids from olive oil to be differentiated from that of steers that consumed soybean oil.

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“…However, this could be ascribed to the fact that R-TFA generally is consumed (1) in much lower quantities than IP-TFA and (2) together with dairy products, which may be heart protective (Warensjo et al, 2010). Alternatively, the weak tendency for a risk reduction seen with R-TFA, may relate to the fact that vaccenic acid may be converted endogenously to the conjugated linoleic acid isomer c9,t11-18:2 (Turpeinen et al, 2002), the adipose tissue content of which has been shown to be inversely associated with myocardial infarction risk (Smit et al, 2010).…”

Section: Nhsmentioning

confidence: 99%

Consumption of industrial and ruminant trans fatty acids and risk of coronary heart disease: a systematic review and meta-analysis of cohort studies

et al. 2011

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The aim of this systematic review and meta-analysis was to summarize the evidence from observational studies assessing the association between intake of trans fatty acids (TFA) and the risk of coronary heart disease (CHD), with a specific emphasis on distinguishing between TFA of industrial and ruminant origin. By searching five bibliographic databases, analyses from six published and two unpublished prospective cohort studies, assessing the association of intake of TFA with fatal and/or non-fatal CHD, were identified. Four and three studies reported separate associations for intake of ruminant or industrial-TFA, respectively. The pooled relative risk estimates for comparison of extreme quintiles of total-TFA intake (corresponding to intake increments ranging from 2.8 to B10 g/day) were 1.22 (95% confidence interval: 1.08-1.38; P ¼ 0.002) for CHD events and 1.24 (1.07-1.43; P ¼ 0.003) for fatal CHD. Ruminant-TFA intake (increments ranging from 0.5 to 1.9 g/day) was not significantly associated with risk of CHD (risk ratio (RR) ¼ 0.92 (0.76-1.11); P ¼ 0.36), and neither was industrial-TFA intake, although there was a trend towards a positive association (RR ¼ 1.21 (0.97-1.50); P ¼ 0.09). In conclusion, our analysis suggests that industrial-TFA may be positively related to CHD, whereas ruminant-TFA is not, but the limited number of available studies prohibits any firm conclusions concerning whether the source of TFA is important. The null association of ruminant-TFA with CHD risk may be due to lower intake levels.

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Bioconversion of vaccenic acid to conjugated linoleic acid in humans

Abstract: The results quantify the desaturation of VA to RA in humans. Conversion is likely to contribute significantly to the amount of RA available to the body, and dietary intakes of VA should thus be taken into account when predicting RA status.

Cited by 417 publications

References 36 publications

Quantitative characterization of unsaturated and trans fatty acids in ewe’s milk fat

Quantitative characterization of unsaturated and trans fatty acids in ewe’s milk fat

Animal performance and meat characteristics in steers reared in intensive conditions fed with different vegetable oils

Consumption of industrial and ruminant trans fatty acids and risk of coronary heart disease: a systematic review and meta-analysis of cohort studies

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