Bioconversion of plant carotenoids to vitamin A in Filipino school-aged children varies inversely with vitamin A status

Ribaya-Mercado, Judy D.; Solon, Florentino S.; Solon, Mercedes A; Cabal-Barza, Marilyn A; Perfecto, Christine S; Tang, Guangwen; Solon, Juan Antonio A.; Fjeld, Carla R.; Russell, Robert M.

doi:10.1093/ajcn/72.2.455

Cited by 90 publications

(66 citation statements)

References 35 publications

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“…With this small sample size, the improvement in the DGLV and control group did not differ from one another, which may indicate regression to the mean (data not shown). However, serum retinol may not be the best indicator for measuring short-term changes in vitamin A status; a recent study by Ribaya-Mercado et al (2000), using 3 days deuterated-retinol dilution, suggests that improvement of vitamin A status after dietary intervention is in¯uenced very little by serum retinol concentrations, but instead is strongly in¯uenced by total body stores of vitamin A.…”

Section: Discussionmentioning

confidence: 99%

Increase in serum beta-carotene following dark green leafy vegetable supplementation in Mebendazole-treated school children in Bangladesh

et al. 2001

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Objective: To study the effect of consumption of dark green leafy vegetables (DGLV) and sweet pumpkin on serum b-carotene and retinol concentrations in children treated for Ascaris lumbricoides. Design: Experimental study with a randomised design. Subjects: A total of 110 primary school children aged 8 ± 12 y in northwestern Bangladesh. Interventions: All children were de-wormed and 2 weeks later randomly assigned to one of three groups to receive for 6 days per week, for 6 weeks, one complete meal containing either: (1) 4.4 mg beta-carotene from DGLV (n 37, after 18 dropouts); (2) 1.5 mg beta-carotene from sweet pumpkin (n 36, 18 dropouts); or (3) vegetables containing virtually no beta-carotene (control) (n 37, 18 dropouts). Results: Signi®cant increases (P`0.001) in mean serum b-carotene concentrations were seen in all three study groups, with a statistically higher increase (mmolal) in the DGLV group (0.44; 95% con®dence interval (CI) 0.32, 0.55) compared to the control group (0.20; 95% CI 0.14, 0.26; P 0.002). The increase in serum retinol (mmolal) was statistically signi®cant (P 0.04) only in the DGLV group (mean 0.066; 95% CI 0.002, 0.13), but this increase was not different from the increase in the control group. Conclusion: In children successfully treated for Ascaris lumbricoides, a substantial increase in serum b-carotene was seen after feeding with a moderately high cumulative dose of DGLV for 6 weeks.

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Section: Discussionmentioning

confidence: 99%

Increase in serum beta-carotene following dark green leafy vegetable supplementation in Mebendazole-treated school children in Bangladesh

et al. 2001

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“…Approximately, 45% of the western population can be classified as low converter [30,47]. It has been established that conversion efficiency is depending at least in part on the vitamin A status [57], which is explained by the existence of a negative feedback of RA on BCMO1 mRNA expression [3,66]. Besides, many studies have highlighted the huge interindividual variability in conversion efficiency, with a coefficient of variation being as high as 221% [7,12,30,47].…”

Section: Carotenoid Oxygenasesmentioning

confidence: 99%

β-Carotene conversion products and their effects on adipose tissue

et al. 2009

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Recent epidemiological data suggest that b-carotene may be protective against metabolic diseases in which adipose tissue plays a key role. Adipose tissue constitutes the major b-carotene storage tissue and its functions have been shown to be modulated in response to b-carotene breakdown products, especially retinal produced after cleavage by b-carotene 15,15 0 -monooxygenase (BCMO1), and retinoic acid arising from oxidation of retinal. However, the possibility exists that b-carotene in its intact form can also affect adipocyte function. Development of a knock out model and identification of a loss-offunction mutation have pointed out BCMO1 as being probably the sole enzyme responsible for provitamin A conversion into retinal in mammals. The utilisation of BCMO1 -/-mice should provide insights on b-carotene effect on its own in the future. In humans, intervention studies have highlighted the huge interindividual variation of b-carotene conversion efficiency, possibly due to genetic polymorphisms, which might impact on response to b-carotene. This brief review discusses the processes involved in b-carotene conversion and the effect of cleavage products on body fat and adipose tissue function.

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“…One approach has been to estimate what the 3-day D : H ratio would have been based on the measured ratio at 21 days, after interfusion of tracer and tracee [15,16]. Recent work summarized below indicates that we may be able to modify the RID equation to both eliminate some of the assumptions and to use data actually collected 3 days after dosing.…”

Section: A Simplifi Ed 3-day Rid Equationmentioning

confidence: 99%

Evaluation of the Olson Equation, an Isotope Dilution Method for Estimating Vitamin A Stores

Green

2014

International Journal for Vitamin and Nutrition Research

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Isotope dilution methods have been successfully used to estimate vitamin A status in human populations as well as to evaluate the impact of vitamin A interventions. The most commonly applied isotope dilution method is the retinol isotope dilution technique, which is based on the 1989 "Olson equation" for estimating total body vitamin A stores (sometimes equated to liver vitamin A) after an oral dose of labeled vitamin A. The equation relies on several factors related to absorption and retention of the dose, the equilibration of label in plasma vs. liver, and timing of a blood sample for measurement of labeled vitamin A. Here, the assumptions underlying these factors are discussed, and new results based on applying model-based compartmental analysis [specifi cally, the Simulation, Analysis and Modeling software (WinSAAM)] to data on retinol kinetics in humans are summarized. A simplifi cation of the Olson equation, in which plasma tracer is measured 3 days after administration of the oral dose and several factors are eliminated, is presented. The potential usefulness of the retinol isotope dilution technique for setting vitamin A requirements and assessing vitamin A status in children, as well as the confounding effects of infl ammation and likely variability in vitamin A absorption, are also discussed.

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Bioconversion of plant carotenoids to vitamin A in Filipino school-aged children varies inversely with vitamin A status

Cited by 90 publications

References 35 publications

Increase in serum beta-carotene following dark green leafy vegetable supplementation in Mebendazole-treated school children in Bangladesh

Increase in serum beta-carotene following dark green leafy vegetable supplementation in Mebendazole-treated school children in Bangladesh

β-Carotene conversion products and their effects on adipose tissue

Evaluation of the Olson Equation, an Isotope Dilution Method for Estimating Vitamin A Stores

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Bioconversion of plant carotenoids to vitamin A in Filipino school-aged children varies inversely with vitamin A status

Cited by 90 publications

References 35 publications

Increase in serum beta-carotene following dark green leafy vegetable supplementation in Mebendazole-treated school children in Bangladesh

Increase in serum beta-carotene following dark green leafy vegetable supplementation in Mebendazole-treated school children in Bangladesh

β-Carotene conversion products and their effects on adipose tissue

Evaluation of the Olson Equation, an Isotope Dilution Method for Estimating Vitamin A Stores

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Evaluation of the Olson Equation, an Isotope Dilution Method for Estimating Vitamin A Stores