Bioconversion of C1 feedstocks for chemical production using Pichia pastoris

Guo, Feng; Qiao, Yangyi; Xin, Fengxue; Zhang, Wenming; Jiang, Min

doi:10.1016/j.tibtech.2023.03.006

Cited by 10 publications

(3 citation statements)

References 70 publications

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“…Consequently, 50% of the carbon is lost in the form of CO 2 the formaldehyde dissimilation pathway. This results in a lower accumulation of metabolites that can be used for the production of chemicals using methanol as a substrate [ 128 ]. Nonetheless, during growth on methanol, P. pastoris has high NADPH/NADP + levels, making it a suitable host for the production of reduced chemicals such as fatty acids [ 30 , 32 ] and terpenoids [ [24] , [25] , [26] ].…”

Section: Discussion and Future Perspectivesmentioning

confidence: 99%

“…Nonetheless, during growth on methanol, P. pastoris has high NADPH/NADP + levels, making it a suitable host for the production of reduced chemicals such as fatty acids [ 30 , 32 ] and terpenoids [ [24] , [25] , [26] ]. In addition, P. pastoris has a relatively higher flux towards the pentose phosphate pathway (PPP) than towards the TCA cycle or glycolysis [ 128 , 129 ]. A higher carbon flux towards PPP allows the generation of E4P, which can be exploited for the production of aromatic compounds such as tyrosine, resveratrol, and naringenin [ 130 ].…”

Section: Discussion and Future Perspectivesmentioning

confidence: 99%

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Methanol-based biomanufacturing of fuels and chemicals using native and synthetic methylotrophs

Sarwar

Lee

2023

Synthetic and Systems Biotechnology

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Section: Discussion and Future Perspectivesmentioning

confidence: 99%

Section: Discussion and Future Perspectivesmentioning

confidence: 99%

Methanol-based biomanufacturing of fuels and chemicals using native and synthetic methylotrophs

Sarwar

Lee

2023

Synthetic and Systems Biotechnology

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“…In addition to the biological technologies discussed above, artificial photosynthesis and artificial biological membranes are being investigated [17,173,174]. Researchers are actively striving to improve the BioCon CO 2 efficiency of these microbes by improving their metabolic pathways using genetic engineering techniques [175,176]. Electrochemical methods have also emerged as promising BioCon CO 2 pathways [177].…”

Section: The Current and Future Trends Of The Biocon Comentioning

confidence: 99%

A Review of the Recent Advancement of Bioconversion of Carbon Dioxide to Added Value Products: A State of the Art

2023

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Excessive dependence on fossil fuels increases GHG emissions and carbon levels in the atmosphere, leading to climatic changes. This phenomenon can be reversed by capturing the carbon via “carbon capture and storage” (CCS) or “carbon capture and utilize” (CCU) technologies. In CCS methods, the captured carbon is stored in natural sinks (e.g., oceans), whereas, in CCU methods, the carbon is converted into useful products. Among CCU methods, the biological conversion of CO2 (BioConCO2) into value-added chemicals has gained great attention. This review focuses on providing an overview of the recent advances in CO2 utilization technology with a focus on the BioConCO2. The theoretical background and technical drivers, challenges, and setbacks of upscaling and commercialization of BioConCO2 are critically discussed with implications for future improvements. The BioConCO2 is increasingly attracting the attention of researchers and industrialists for its capacity to operate under low CO2 concentrations and in the presence of impurities (common conditions in industrial flue gases)—among other numerous advantages. While upscaling algae-based BioConCO2 has operational and financial challenges, bioconversion via bacteria and genetically engineered cyanobacterial seems promising due to their efficiency and flexibility.

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