Biocompatible well-defined chromophore–polymer conjugates for photodynamic therapy and two-photon imaging

Cepraga, Cristina; Gallavardin, Thibault; Marotte, Sophie; Lanoë, Pierre‐Henri; Mulatier, Jean‐Christophe; Lerouge, Frédéric; Parola, Stéphane; Lindgren, Mikael; Baldeck, Patrice L.; Marvel, Jacqueline; Maury, Olivier; Monnereau, Cyrille; Favier, Arnaud; Andraud, Chantal; Leverrier, Yann; Charreyre, Marie‐Thérèse

doi:10.1039/c2py20565c

Cited by 37 publications

(45 citation statements)

References 24 publications

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“…We can find that their theoretically [309] and experimentally [310] analyzed cooperative enhancement of two photon absorption is due to the generation of excitons. In this regard, also, their performance is dramatically different from the behavior of organic dyes assembled in detergent micelles [311] or polymer conjugates [312], in which high performance is achieved due to only to the local concentration effects. Within the frame of exciton theory, the intensive nonlinear optical response could be explained by the occurrence of the large oscillator strength generated by one or few delocalized excitonic states.…”

Section: Strong Two-photon Absorbancementioning

confidence: 96%

Excitons in Carbonic Nanostructures

Demchenko

2019

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Unexpectedly bright photoluminescence emission can be observed in materials incorporating inorganic carbon when their size is reduced from macro–micro to nano. At present, there is no consensus in its understanding, and many suggested explanations are not consistent with the broad range of experimental data. In this Review, I discuss the possible role of collective excitations (excitons) generated by resonance electronic interactions among the chromophore elements within these nanoparticles. The Förster-type resonance energy transfer (FRET) mechanism of energy migration within nanoparticles operates when the composing fluorophores are the localized electronic systems interacting at a distance. Meanwhile, the resonance interactions among closely located fluorophores may lead to delocalization of the excited states over many molecules resulting in Frenkel excitons. The H-aggregate-type quantum coherence originating from strong coupling among the transition dipoles of adjacent chromophores in a co-facial stacking arrangement and exciton transport to emissive traps are the basis of the presented model. It can explain most of the hitherto known experimental observations and must stimulate the progress towards their versatile applications.

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Section: Strong Two-photon Absorbancementioning

confidence: 96%

Excitons in Carbonic Nanostructures

Demchenko

2019

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“…Conjugated polymers with expanded π‐conjugated structures generally achieve larger 2PA coefficients. Moreover, the abundant activated sites on the polymer backbone and chain can be modified to regulate its hydrophobic/hydrophilic balance and introduce specific targeting groups . Some conjugated polymers have already been designed and employed for 2PE‐PDT applications.…”

Section: Progress Of Pss For 2pe‐pdtmentioning

confidence: 99%

Photosensitizers for Two‐Photon Excited Photodynamic Therapy

Sun

Zhang

et al. 2017

Adv Funct Materials

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Photodynamic therapy (PDT) is a noninvasive protocol for the treatment of various cancers and nonmalignant diseases. Light, oxygen, and photosensitizer (PS) are the essential three elements in a typical PDT process. Currently, there are two major barriers limiting the further development of PDT. One issue is limited tissue penetration, and the other is the lack of high-performance PSs. Therefore, the newly emerging two-photon excited PDT (2PE-PDT) has attracted considerable attention in recent years due to its advantages such as a higher spatial resolution and a greater penetration depth. In this review, focus is on (i) the principle of 2PE-PDT, (ii) the progression of PSs for 2PE-PDT, and (iii) the potential indications and future directions in this field.

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“…However, as most of the probes that exhibit interesting TPA properties, it was a hydrophobic fluorophore. Our recent experience with hydrophobic TPA dyes (emitting in the visible range) demonstrated that it is indeed possible to get water-soluble and biocompatible dye-polymer conjugates provided that a biocompatible polymer backbone is used and that the number of dyes per chain is controlled [16]. By tuning the nature of the groups along the polymer chain and the number of far-red dyes per chain, we could synthesize fluorescent polymer probes that were water-soluble and exhibited a much higher brightness than the corresponding molecular dye (up to 10 fold).…”

Section: Introductionmentioning

confidence: 99%