Biocompatible Slippery Fluid-Infused Films Composed of Chitosan and Alginate via Layer-by-Layer Self-Assembly and Their Antithrombogenicity

Manabe, Kengo; Kyung, Kyu Hong; Shiratori, Seimei

doi:10.1021/am508393n

Cited by 114 publications

(94 citation statements)

References 60 publications

(112 reference statements)

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“…Miscibility of the lubricant with intruding liquids is also a limitation, necessary to be aware of. [19b] Although there are reports on biocompatible slippery lubricantinfused surfaces composed of, for example, chitosan and alginates, [116] majority of SLIPS contain fluorinated lubricants. It will be necessary to minimize the use of fluorine containing chemicals and replace them with more ecofriendly and biocompatible alternatives in the future.…”

Section: Discussionmentioning

confidence: 99%

Slippery Lubricant‐Infused Surfaces: Properties and Emerging Applications

Ueda

Paulssen

et al. 2018

Adv Funct Materials

183

138

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Bioinspired lubricant-infused surfaces exhibit various unique properties attributed to their liquid-like and molecularly smooth nature. Excellent liquid repellency and "slippery" properties, self-healing, antiicing, anticorrosion characteristics, enhanced heat transfer, antibiofouling, and cell-repellent properties have been already demonstrated. This progress report highlights some of the recent developments in this rapidly growing area, focusing on properties of lubricant-infused surfaces, and their emerging applications as well as some future challenges.coatings. [8] In order to solve the abovementioned limitations of traditional superhydrophobic and superoleophobic surfaces, Quéré, Aizenberg, and Varanasi proposed bioinspired slippery liquidinfused porous surface (SLIPS) or lubricant-impregnated surfaces combining the mechanical stability of a solid substrate with the liquid-like properties and molecularly smoothness of the lubricant interface. [9a-d] It should be noted that stabilization of a lubricant layer on solid surfaces by forming a thin polymer film that can be swollen in the lubricant was introduced in 1988 by Karakelle and Zdrahala from Bekton, Dickinson and Company.[9e] They also demonstrated excellent long-term stability, liquid repellency, and proposed various medical applications of lubricant-impregnated surfaces. SLIPSs mimic the Nepenthes pitcher plant surface, [10] which is textured and can be lubricated with an aqueous solution. [11] The unique slippery character of the [9a] Nepenthes pitcher plant's surface resulting from water lubrication helps it capture insects sliding into its interior. To mimic the Nepenthes pitcher plant surface, a lubricating hydrophobic liquid can be infused into different hydrophobic porous or rough substrates to form SLIPS. [9] By matching the surface energy of the underlying porous substrate and the hydrophobic lubricant, the liquid can be stabilized on the surface of the substrate to form SLIPS. [9a] Depending on the impregnated lubricant, SLIPSs possess excellent repellency and drop mobility to a broad range of liquids including low surface tension liquids, and complex fluids such as blood or cell medium. [9a] This liquid repellency as well as SLIPS′ self-healing properties are due to the mobility of the lubricant trapped inside the porous surface structures. [12] Lubricant-infused surfaces demonstrated icephobic, stainresistant, biofilm-or cell-repellent or marine antibiofouling properties as well as tolerance to high pressure and transparency. [9,13] All of these unique properties make SLIPS interesting for the development of novel functional materials and various practical applications.The goal of this progress report is not to comprehensively review this broad and dynamic research field but rather highlight selected important aspects that have been less reviewed so far despite their potential. Some important and related papers could not be cited due to the length limitations. We also refer readers to several excellent reviews covering applications of ...

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Section: Discussionmentioning

confidence: 99%

Slippery Lubricant‐Infused Surfaces: Properties and Emerging Applications

Ueda

Paulssen

et al. 2018

Adv Funct Materials

183

138

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“…Recently, liquid-infused coatings, consisting of a porous structure infiltrated with a lubricant, have emerged as a new, alternative strategy for repellent materials (11,(13)(14)(15)(16)(17). The formation of a stable lubricant overlayer on the surface creates a dynamic slippery barrier that protects the underlying substrate from direct contact with polluted media, thus drastically lowering the adsorption of various serious contaminants including bacteria (18,19) and proteins (20)(21)(22). This new, non-fouling material can be designed to perform under flow (23,24), provide enhanced damage tolerance (15,16) and selfhealing capabilities (11), or be integrated with a vascularized network that secretes the lubricant to repair the interface (25,26).…”

Section: Significancementioning

confidence: 99%

“…The characteristics of liquid-infused coatings may provide a potential solution to mitigate the performance concerns in endoscopes, especially because methodologies have been developed to create transparent coatings with efficient liquid repellency (16,(20)(21)(22)27). Here, we design and explore the function of a liquid-infused coating applied on a bronchoscope lens during clinically relevant procedures.…”

Section: Significancementioning

confidence: 99%

Transparent antifouling material for improved operative field visibility in endoscopy

Sunny

Cheng

Daniel

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

115

125

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Camera-guided instruments, such as endoscopes, have become an essential component of contemporary medicine. The 15–20 million endoscopies performed every year in the United States alone demonstrate the tremendous impact of this technology. However, doctors heavily rely on the visual feedback provided by the endoscope camera, which is routinely compromised when body fluids and fogging occlude the lens, requiring lengthy cleaning procedures that include irrigation, tissue rubbing, suction, and even temporary removal of the endoscope for external cleaning. Bronchoscopies are especially affected because they are performed on delicate tissue, in high-humidity environments with exposure to extremely adhesive biological fluids such as mucus and blood. Here, we present a repellent, liquid-infused coating on an endoscope lens capable of preventing vision loss after repeated submersions in blood and mucus. The material properties of the coating, including conformability, mechanical adhesion, transparency, oil type, and biocompatibility, were optimized in comprehensive in vitro and ex vivo studies. Extensive bronchoscopy procedures performed in vivo on porcine lungs showed significantly reduced fouling, resulting in either unnecessary or ∼10–15 times shorter and less intensive lens clearing procedures compared with an untreated endoscope. We believe that the material developed in this study opens up opportunities in the design of next-generation endoscopes that will improve visual field, display unprecedented antibacterial and antifouling properties, reduce the duration of the procedure, and enable visualization of currently unreachable parts of the body, thus offering enormous potential for disease diagnosis and treatment.

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“…However, many reports on the anti-inflammatory effects of isolated or synthesized flavonoids have been published. Indeed, many previous studies suggest that flavonoids have a variety of useful effects such as antitumor, antibacterial, antivirus, anti-inflammation, immunoregulation, and antithrombogenicity activities [11–15]. …”

Section: Introductionmentioning

confidence: 99%

5,7‐Dihydroxyflavone Analogues May Regulate Lipopolysaccharide‐Induced Inflammatory Responses by Suppressing IκBα‐Linked Akt and ERK5 Phosphorylation in RAW 264.7 Macrophages

Nishina

Shimizu

Koketsu

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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We studied the anti-inflammatory activity of twelve 5,7-dihydroxyflavone analogues in lipopolysaccharide- (LPS-) stimulated RAW 264.7 macrophages. We found that chrysin (1) and 4′-methoxytricetin (9) showed relatively significant anti-inflammatory activity and low cytotoxicity. Moreover, 1 and 9 recovered the expression levels of iNOS and COX2, as well as those of the intracellular inflammatory mediators IL-1β and IL-6, which were upregulated by LPS stimulation. In addition, 1 and 9 actively regulated the phosphorylation of IκBα, leading to the activation of NFκB. Phosphorylation of Akt and ERK5 (upstream of NFκB) by LPS stimulation was significantly regulated by 1 and 9, as well as by BIX 02189 and LY 294002, which are phosphorylation inhibitors of ERK5 and Akt, respectively. The results suggest that compounds 1 and 9 may suppress the levels of iNOS and COX2 by regulating phosphorylation of Akt, ERK5, and IκBα and thus NFκB-related signaling pathways, resulting in anti-inflammatory effects in the cells. Because 1 and 9 showed low cytotoxicity and regulated both PGE2 and NO production caused by inflammatory responses, they may hold promise as natural anti-inflammatory agents.

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Biocompatible Slippery Fluid-Infused Films Composed of Chitosan and Alginate via Layer-by-Layer Self-Assembly and Their Antithrombogenicity

Cited by 114 publications

References 60 publications

Slippery Lubricant‐Infused Surfaces: Properties and Emerging Applications

Slippery Lubricant‐Infused Surfaces: Properties and Emerging Applications

Transparent antifouling material for improved operative field visibility in endoscopy

5,7‐Dihydroxyflavone Analogues May Regulate Lipopolysaccharide‐Induced Inflammatory Responses by Suppressing IκBα‐Linked Akt and ERK5 Phosphorylation in RAW 264.7 Macrophages

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