Biocompatible quaternary pullulan functionalized 2D MoS<sub>2</sub> glycosheet-based non-leaching and infection-resistant coatings for indwelling medical implants

Roy, Shounak; Haloi, Prakash; B., Siva Lokesh; Chawla, Saurabh; Badireenath Konkimalla, V.; Jaiswal, Amit

doi:10.1039/d3tb01816d

J. Mater. Chem. B

2023

DOI: 10.1039/d3tb01816d

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Biocompatible quaternary pullulan functionalized 2D MoS₂ glycosheet-based non-leaching and infection-resistant coatings for indwelling medical implants

Shounak Roy,

Prakash Haloi,

Siva Lokesh B.

et al.

Abstract: Medical implants are frequently used in medicine and reconstructive surgery to treat various pathological and anatomical conditions. However, over time, biofilm formation on the surface of these implants can cause...

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2024

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Enhanced Antibacterial and Antibiofilm Activities of Actinobacterial Therapeutic Metabolites Mediated Nanosuspension

Singh,

Sharma,

Dubey

2024

Part & Part Syst Charact

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The escalation in infections from World Health Organization (WHO)‐listed priority pathogens has made development of new antibacterial agents a critical priority. In this context, use of therapeutic secondary metabolites (SMs) from Actinobacteria as new drugs presents a promising avenue. However, majority of them fail to reach market due to low aqueous solubility and hence low bioavailability. Even though nanosuspension technology has been effectively used to address these challenges, use of this technology for nanox02010;listed priority pathogens has made development of new antibacterial agents a critical priority. In thitransformation of crude metabolites from Actinobacteria is still an unattempted area. Herein, for the first time, development of water‐soluble nanosuspension of water‐insoluble therapeutic metabolites produced by Streptomyces californicus strain ADR1 to develop a biocompatible material to be used as potential nanomedicine is reported. The nanosuspension (N‐SM) is characterized by UV‐vis spectroscopy, transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), and dynamic light scattering (DLS). The nanosuspension reduces the MIC values by 50% against Gram‐positive priority pathogens and eradicates established biofilms with fivefold efficiency incomparison to SMs. The nanosuspension also displays antioxidant activity. The findings open up future possibilities of using this novel nanosuspension as an effective antibacterial agent in various therapeutic and biomedical applications like wound dressings, coatings on medical equipment, and surgical implants.

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Enhanced Antibacterial and Antibiofilm Activities of Actinobacterial Therapeutic Metabolites Mediated Nanosuspension

Singh,

Sharma,

Dubey

2024

Part & Part Syst Charact

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Recent innovations (2020–2023) in the approaches for the chemical functionalization of curdlan and pullulan: A mini-review

Ganie,

Rather,

Assiri

et al. 2024

International Journal of Biological Macromolecules

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Biocompatible quaternary pullulan functionalized 2D MoS₂ glycosheet-based non-leaching and infection-resistant coatings for indwelling medical implants

Abstract: Medical implants are frequently used in medicine and reconstructive surgery to treat various pathological and anatomical conditions. However, over time, biofilm formation on the surface of these implants can cause...

Cited by 2 publications

References 37 publications

Enhanced Antibacterial and Antibiofilm Activities of Actinobacterial Therapeutic Metabolites Mediated Nanosuspension

Enhanced Antibacterial and Antibiofilm Activities of Actinobacterial Therapeutic Metabolites Mediated Nanosuspension

Recent innovations (2020–2023) in the approaches for the chemical functionalization of curdlan and pullulan: A mini-review

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Biocompatible quaternary pullulan functionalized 2D MoS2 glycosheet-based non-leaching and infection-resistant coatings for indwelling medical implants

Abstract: Medical implants are frequently used in medicine and reconstructive surgery to treat various pathological and anatomical conditions. However, over time, biofilm formation on the surface of these implants can cause...

Cited by 2 publications

References 37 publications

Enhanced Antibacterial and Antibiofilm Activities of Actinobacterial Therapeutic Metabolites Mediated Nanosuspension

Enhanced Antibacterial and Antibiofilm Activities of Actinobacterial Therapeutic Metabolites Mediated Nanosuspension

Recent innovations (2020–2023) in the approaches for the chemical functionalization of curdlan and pullulan: A mini-review

Contact Info

Product

Resources

About

Biocompatible quaternary pullulan functionalized 2D MoS₂ glycosheet-based non-leaching and infection-resistant coatings for indwelling medical implants