Biocompatible polypyrrole nanoparticles as a novel organic photoacoustic contrast agent for deep tissue imaging

Zha, Zhengbao; Deng, Zijian; Li, Yanyan; Li, Changhui; Wang, Jinrui; Wang, Shumin; Qu, Enze; Dai, Zhifei

doi:10.1039/c3nr00627a

Cited by 193 publications

(174 citation statements)

References 39 publications

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“…Polypyrrole nanoparticles were recently investigated as photoacoustic contrast agent. 184 Absorbance was strongest between 800 and 900 nm (∼2 × 10 10 M −1 cm −1 ), which lies directly within the first optical window where absorption by blood and water is minimized. 185 To test the limits of detectability, polypyrrole nanoparticles embedded in a gel phantom were placed beneath varying thicknesses of chicken breast muscle tissue.…”

Section: Nanoemulsionsmentioning

confidence: 99%

Molecular Interactions in Organic Nanoparticles for Phototheranostic Applications

2015

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Section: Nanoemulsionsmentioning

confidence: 99%

Molecular Interactions in Organic Nanoparticles for Phototheranostic Applications

2015

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“…By using a 1064 nm contrast agent, the laser provided an imaging depth of 4.1 cm. This result represents the first over 4 cm photoacoustic imaging using a portable light source [27, [44][45][46]. The compact laser can also be applied for in vivo animal and human imaging.…”

Section: Human Imagingmentioning

confidence: 99%

Deep tissue photoacoustic computed tomography with a fast and compact laser system

Wang

et al. 2016

Biomed. Opt. Express

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Photoacoustic computed tomography (PACT) holds great promise for biomedical imaging, but wide-spread implementation is impeded by the bulkiness of flash-lamp-pumped laser systems, which typically weigh between 50 -200 kg, require continuous water cooling, and operate at a low repetition rate. Here, we demonstrate that compact lasers based on emerging diode technologies are well-suited for preclinical and clinical PACT. The diodepumped laser used in this study had a miniature footprint (13 × 14 × 7 cm 3 ), weighed only 1.6 kg, and outputted up to 80 mJ per pulse at 1064 nm. In vitro, the laser system readily provided over 4 cm PACT depth in chicken breast tissue. In vivo, in addition to high resolution, non-invasive brain imaging in living mice, the system can operate at 50 Hz, which enabled high-speed cross-sectional imaging of murine cardiac and respiratory function. The system also provided high quality, high-frame rate, and non-invasive three-dimensional mapping of arm, palm, and breast vasculature at multi centimeter depths in living human subjects, demonstrating the clinical viability of compact lasers for PACT.

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“…24 In recent years, researchers are starting to realize their potential as PA contrast agents. 25,26 In this study, we employed a CP, poly[9,9-bis(4-(2-ethylhexyl)phenyl)fluorene-alt-co-6,7-bis(4-(hexyloxy)phenyl)-4,9-di(thiophen-2-yl)thiadiazoloquinoxaline] (PFTTQ, Figure 1A) …”

mentioning

confidence: 99%

Molecular photoacoustic imaging of breast cancer using an actively targeted conjugated polymer

Balasundaram¹,

Ho²,

Li³

et al. 2015

IJN

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Conjugated polymers (CPs) are upcoming optical contrast agents in view of their unique optical properties and versatile synthetic chemistry. Biofunctionalization of these polymer-based nanoparticles enables molecular imaging of biological processes. In this work, we propose the concept of using a biofunctionalized CP for noninvasive photoacoustic (PA) molecular imaging of breast cancer. In particular, after verifying the PA activity of a CP nanoparticle (CP dots) in phantoms and the targeting efficacy of a folate-functionalized version of the same (folate-CP dots) in vitro, we systemically administered the probe into a folate receptor-positive (FR+ve) MCF-7 breast cancer xenograft model to demonstrate the possible application of folate-CP dots for imaging FR+ve breast cancers in comparison to CP dots with no folate moieties. We observed a strong PA signal at the tumor site of folate-CP dots-administered mice as early as 1 hour after administration as a result of the active targeting of the folate-CP dots to the FR+ve tumor cells but a weak PA signal at the tumor site of CP-dots-administered mice as a result of the passive accumulation of the probe by enhanced permeability and retention effect. We also observed that folate-CP dots produced ~4-fold enhancement in the PA signal in the tumor, when compared to CP dots. These observations demonstrate the great potential of this active-targeting CP to be used as a contrast agent for molecular PA diagnostic imaging in various biomedical applications.

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Biocompatible polypyrrole nanoparticles as a novel organic photoacoustic contrast agent for deep tissue imaging

Cited by 193 publications

References 39 publications

Molecular Interactions in Organic Nanoparticles for Phototheranostic Applications

Molecular Interactions in Organic Nanoparticles for Phototheranostic Applications

Deep tissue photoacoustic computed tomography with a fast and compact laser system

Molecular photoacoustic imaging of breast cancer using an actively targeted conjugated polymer

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