Biocompatible Polymers, Metals, and Composites

Selected topics in biomedical polyurethanes. A review

“…Interaction of the tissue with the material may result, however, in a continuation of the chronic inflammatory phase or lead to increased fibrosis or excessive capsule thickening. This may involve adjacent organs or tissues and lead to adverse reactions [95]. In the extreme, solid, thick implants with large smooth, uninterrupted surfaces and sharp edges, may lead to solid-state carcinogenesis [96][97][98].…”

Adsorption of Complement Protein C3 at Polymer Surfaces

“…This regulatory system phase diagnostics, and extracorporeal therapy (1,2). In most constitutes the essential mechanism for the recognition funcof these applications the polymer surface interacts with a tion of the alternative pathway.…”

“…Examples of such responses include undertook the present study. In particular, since C3 plays a frequently observed inflammations related to the use of bio-central role in both the classical and alternative pathways materials, premature removal of colloidal drug carriers from we investigate the state of adsorption (adsorbed amount, circulation in bloodstream and subsequent accumulation in, adsorbed layer structure and formation, competitive adsorption) of this protein at poly(methyl methacrylate) (PMMA) 1 To whom correspondence should be addressed. and poly(styrene) (PS), two polymers frequently used in biomedical applications.…”

Electrotherapy of the Heart

“…Examples include the housings and leads of cardiac pacemakers, neurostimulators, defibrillators, systems for the storage and timed release of drugs, tissue adhesives, and materials for plastic and reconstructive surgery [166,167].…”