Biocompatible polymer coating of titania nanotube arrays for improved drug elution and osteoblast adhesion

Gulati, Karan; Ramakrishnan, Saminathan; Aw, Moom Sinn; Atkins, Gerald J.; Findlay, David M.; Lošić, Dušan

doi:10.1016/j.actbio.2011.09.004

Cited by 257 publications

(176 citation statements)

References 36 publications

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“…Bacterial infection may delay osseointegration, compromising tissue cell functions and even leading to implant failure [21]. A surface with antibacterial properties, high capacity for cell attachment and able to release biological factors could be an effective way to avoid bacteria adhesion and improve osseointegration.…”

Section: Discussionmentioning

confidence: 99%

Anhydride-functional silane immobilized onto titanium surfaces induces osteoblast cell differentiation and reduces bacterial adhesion and biofilm formation

Godoy-Gallardo

Guillem-Marti

Sevilla

et al. 2016

Materials Science and Engineering: C

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Bacterial infection in dental implants along with osseointegration failure usually leads to loss of the device. Bioactive molecules with antibacterial properties can be attached to titanium surfaces with anchoring molecules such as silanes, preventing biofilm formation and improving osseointegration. Properties of silanes as molecular binders have been thoroughly studied, but research on the biological effects of these coatings is scarce. The aim of the present study was to determine the in vitro cell response and antibacterial effects of triethoxysilypropyl succinic anhydride (TESPSA) silane anchored on titanium surfaces. X-ray photoelectron spectroscopy confirmed a successful silanization. The silanized surfaces showed no cytotoxic effects. Gene expression analyses of Sarcoma Osteogenic (SaOS-2) osteoblast-like cells cultured on TESPSA silanized surfaces reported a remarkable increase of biochemical markers related to induction of osteoblastic cell differentiation. A manifest decrease of bacterial adhesion and biofilm formation at early stages was observed on treated substrates, while favoring cell adhesion and spreading in bacteria-cell co-cultures.Surfaces treated with TESPSA could enhance a biological sealing on implant surfaces against bacteria colonization of underlying tissues. Furthermore, it can be an effective anchoring platform of biomolecules on titanium surfaces with improved osteoblastic differentiation and antibacterial properties.

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Section: Discussionmentioning

confidence: 99%

Anhydride-functional silane immobilized onto titanium surfaces induces osteoblast cell differentiation and reduces bacterial adhesion and biofilm formation

Godoy-Gallardo

Guillem-Marti

Sevilla

et al. 2016

Materials Science and Engineering: C

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“…43 Excellent osteoblast adhesion and cell proliferation on polymer-coated TNTs compared with uncoated TNTs were also observed.…”

mentioning

confidence: 89%

Nanotubes Reinforcement of Degradable Polymers for Orthopedic Applications

Kozaniti

Papanikolaki

Theofanis

et al. 2017

ATROA

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Biodegradable polymers have been studied as scaffolds for bone tissue engineering applications. However, they possess insufficient mechanical properties to be considered as alternatives at sites of increased mechanical loading. To improve their mechanical properties, reinforcing with nanotubes has been investigated, as they reproduce the structure and length scale of bone native topography. The research advances in the use of nanotubes as reinforcing agents in developing nanocomposites with synthetic and natural biodegradable polymers are reviewed. The extent of mechanical reinforcement of the polymers and the corresponding biological response of the nanocomposites are presented.

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“…Idea of gradual release of the antimicrobial substances by the implant has leaded coating titanium surface with antibiotics with restricted success limited time of degradation process of antimicrobial drug coating [80]. Several local drug delivery vehicles like (glycolic, lactic acid, caprolactone, methyl methacrylate polymers, chitosan, agarose/hydro-gels, bioactive ceramics, collagen, nanotubes), have been studied to prolong releasing period of the antibiotic [81][82][83]. Choice of delivery medium is dependent on:…”

Section: Implant-associated Infectionmentioning

confidence: 99%