Biocompatible phosphate anchored Fe₃O₄ nanocarriers for drug delivery and hyperthermia

Abstract

Development of water-dispersible phosphate anchored Fe3O4 magnetic nanocarriers by conjugation of bioactive sodium hexametaphosphate for drug delivery and hyperthermia applications.

Preparation and characterization of poly(glycidyl methacrylate)-grafted magnetic nanoparticles: Effects of the precursor concentration on polyol synthesis of Fe3O4 and [PMDETA]0/[CuBr2]0 ratios on SI-AGET ATRP

“…Magnetite (Fe 3 O 4 ) nanoparticles (NPs) have been developed for their fundamental scientific and technological interest including magnetic energy storage, 1 cell separation, 2 targeted drug delivery, 3 selective enrichment, 4 hyperthermia treatment, 5 and magnetic resonance imaging (MRI). 6 Control of the size and different morphologies (spherical, octahedral and cubic) of monodisperse Fe 3 O 4 NPs is very important because these various structures generate distinct properties.…”

Water-dispersible polyphosphate-grafted Fe3O4 nanomagnets for cancer therapy

“…18 Sahoo et al demonstrated the conjugation of alkyl phosphonates and phosphate to Fe 3 O 4 nanoparticles via formation of P-O-Fe bonding. 19 The formation of these water dispersible Fe 3 O 4 nanoparticles has been attributed to the presence of bioactive phosphate molecules on their surface. 19 The formation of these water dispersible Fe 3 O 4 nanoparticles has been attributed to the presence of bioactive phosphate molecules on their surface.…”

Covalent bridging of surface functionalized Fe3O4 and YPO4:Eu nanostructures for simultaneous imaging and therapy

“…The Néel and Brownian relaxation losses are associated with the magnetic moment rotations within the particles (due to internal fluctuations of the magnetic moment with respect to the crystal lattice) and with the entire particles (due to mechanical friction with the surrounding medium when nanoparticles keep oscillating toward the field, keeping its magnetic moment fixed along the crystal axis), respectively. The relaxation times are given by the following equations 31,32 : k is Boltzmann's constant, T is temperature, η is the viscosity and H R is the hydrodynamic particle radius. The use of magnetic nanoparticles in hyperthermia therapy depends on their heating efficiency, which is expressed in terms of the specific absorption rate (SAR).…”