Biocompatible nanofibers based on extremophilic bacterial polysaccharide, Mauran from Halomonas maura

Raveendran, Sreejith; Dhandayuthapani, Brahatheeswaran; Nagaoka, Yutaka; Yoshida, Yasuhiko; Maekawa, Toru; Kumar, D. Sakthi

doi:10.1016/j.carbpol.2012.10.033

Cited by 34 publications

(24 citation statements)

References 29 publications

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“…Similarly, electrospun MR-Poly Vinyl Alcohol (MR-PVA) nanofi bre membranes (Fig. 4.3 ) boost the cellular adhesion, migration, proliferation and differentiation, properties desirable for tissue engineering applications (Raveendran et al 2013c ). MR may be used in augmenting the biocompatibility of quantum dots that are usually cytotoxic (Fig.…”

Section: Halophilic Bacteria and Nanofabricationmentioning

confidence: 99%

Biosynthesis of Nanoparticles from Halophiles

Srivastava

Kowshik

2015

Sustainable Development and Biodiversity

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Nanobiotechnology is a multidisciplinary branch of nanotechnology which includes fabrication of nanomaterials using biological approaches. Many bacteria, yeast, fungi, algae and viruses have been used for synthesis of various metallic, metal sulfi de, metal oxide and alloy nanoparticles , since the fi rst report on biosynthesis of cadmium sulfi de quantum dots by Candida glabrata and Schizosaccharomyces pombe in 1989. These nanofactories offer a better size control through compartmentalization in the periplasmic space and vesicles, and are usually capped by stabilizing cellular metabolites. Halophiles depending on their salt requirements may be classifi ed as slight, moderate and extreme halophiles. They are found in marine and/or hypersaline environments. These organisms are known to encounter metals in their environment as the econiches they inhabit serve as ecological sinks for metals. Metal based nanoparticle synthesis by halophilic organisms is in its infancy and has only been reported in few organisms. This chapter aims to shed light on the various halophilic organisms and their by-products that have been exploited for nanomaterial synthesis, the mechanisms that may be involved in the nanomaterial fabrication and the possible applications of the fabricated nanoparticles. A special section would be dedicated for the bioavailability of metals to halophiles under varying salinity conditions.

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Section: Halophilic Bacteria and Nanofabricationmentioning

confidence: 99%

Biosynthesis of Nanoparticles from Halophiles

Srivastava

Kowshik

2015

Sustainable Development and Biodiversity

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“…Standard protocols with slight modifications were used for assaying antioxidant enzymes. Effect of oxidation stress and the amount of its inhibition by MR was evaluated using optical density (OD) measurement by UV-Visible spectrophotometer [32]. Experiment was performed in triplicates and results were plotted as mean ± S.E.…”

Section: Preparation Of Mammalian Cell and Tissue Homogenatesmentioning

confidence: 99%

“…MR and CH was separately conjugated with fluorescent dyes, sypro ruby (SR) biofilm matrix stain and fluorescein isothiocyanate (FITC) respectively. Apart from the anticancer property, MR was found to be a potential antioxidant molecule [32]. In the present work, we are comparing the anticancer mechanism of drug loaded MR/CH Nps using 2 different cancer cell lines: glioma and breast adenocarcinoma and finding the possibility of its application as a novel incipient polysaccharide nanoparticle for defending oxidative stress.…”

Section: Introductionmentioning

confidence: 98%

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Extremophilic polysaccharide nanoparticles for cancer nanotherapy and evaluation of antioxidant properties

Raveendran

Palaninathan

Nagaoka

et al. 2015

International Journal of Biological Macromolecules

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“…The monosaccharides present in mauran include mannose, galactose, glucose and glucuronic acid in addition to sulfate and phosphate groups (Raveendran et al, 2013). In contrast to other anionic polysaccharides, it possesses unique property of being resistant to high salt concentrations and its conformation or its viscosity remains unaffected in the presence of cations (Rehm, 2009).…”

Section: Mauranmentioning

confidence: 99%

Absorption, distribution, metabolism and elimination (ADME) and toxicity profile of marine sulfated polysaccharides used in bionanotechnology

Majee¹,

Avlani²,

Ghosh³

et al. 2018

Afr. J. Pharm. Pharmacol.

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Sulfated polysaccharides extracted from marine algae and bacteria constitute an important class of biomacromolecules as they are characterized by biocompatibility, biodegradability and low immunogenicity. Recent advances in bionanotechnology are attributed to identification of marine sulfated polysaccharides of unique composition and functional properties. Promising results obtained so far justify the need for additional research in the study of absorption, distribution, metabolism and elimination (ADME) of these novel biopolymer-based nanomaterials in human body after administration by oral or parenteral route for therapeutic or diagnostic purpose. In vitro enzymatic degradation pathways should be investigated in order to yield commercially valuable oligomers. The goal of the present review is to enlighten on the ADME, cytotoxicity and in vitro enzymatic degradation of three marine sulfated polysaccharides, fucoidan, ulvan and mauran, obtained from brown seaweeds or macroalgae in the class of Phaeophyceae, members of Ulvales (green algae) and halophilic bacteria, respectively. They are presently being exploited in fabrication of nanoplatforms with novel applications in the field of controlled drug delivery, tissue regeneration scaffolds, cancer therapy, and bioimaging. However, significant research still needs to be carried out to characterize ADME of mauran and to improve production of the biopolymers on a large scale in order to find out clinically relevant solutions to establish these sulfated polysachharide-based nanotools as novel bionanotechnology strategies in future.

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Biocompatible nanofibers based on extremophilic bacterial polysaccharide, Mauran from Halomonas maura

Cited by 34 publications

References 29 publications

Biosynthesis of Nanoparticles from Halophiles

Biosynthesis of Nanoparticles from Halophiles

Extremophilic polysaccharide nanoparticles for cancer nanotherapy and evaluation of antioxidant properties

Absorption, distribution, metabolism and elimination (ADME) and toxicity profile of marine sulfated polysaccharides used in bionanotechnology

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