Extremophilic polysaccharide nanoparticles for cancer nanotherapy and evaluation of antioxidant properties

Raveendran, Sreejith; Palaninathan, Vivekanandan; Nagaoka, Yutaka; Fukuda, Toshio; Iwai, Seiki; Higashi, Toshiaki; Mizuki, Toru; Sakamoto, Yasushi; Mohanan, P.V.; Maekawa, Toru; Kumar, D. Sakthi

doi:10.1016/j.ijbiomac.2015.03.001

Cited by 33 publications

(16 citation statements)

References 46 publications

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“…These toxic effects can be attributed to the damage of exopolysaccharide layer on MRGO as a result of autoclaving (Cherian et al, 2014). In another study, mauran-chitosan composite nanoparticles did not induce ROS generation and thus did not affect the polyunsaturated fatty acids of fatty acid membrane or initiate chain reaction posing threat to the tissue system (Raveendran et al, 2015). Mauran-chitosan nanoparticles loaded with 5-fluorouracil did not elicit any toxicity in mouse connective tissue fibroblast cells (L929) (Posocco et al, 2015).…”

Section: Cytotoxicity Of Marine Sulfated Polysaccharidesmentioning

confidence: 93%

“…Fabrication and active targeting of these nanocrystals has significantly improved binding to and uptake by cancer cells and tumor masses, promoting site-specific delivery and imaging. It has also attracted attention in the repertoire of tissue engineering for development of porous nanoscaffolds for cellular regeneration due to its enhanced cell adhesion and proliferative activities observed during in vitro cell culture studies (Raveendran et al, 2014;Raveendran et al,2015) …”

Section: Marine Sulfated Polysaccharides As Bionanotechnology Platformsmentioning

confidence: 99%

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Absorption, distribution, metabolism and elimination (ADME) and toxicity profile of marine sulfated polysaccharides used in bionanotechnology

Majee¹,

Avlani²,

Ghosh³

et al. 2018

Afr. J. Pharm. Pharmacol.

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Sulfated polysaccharides extracted from marine algae and bacteria constitute an important class of biomacromolecules as they are characterized by biocompatibility, biodegradability and low immunogenicity. Recent advances in bionanotechnology are attributed to identification of marine sulfated polysaccharides of unique composition and functional properties. Promising results obtained so far justify the need for additional research in the study of absorption, distribution, metabolism and elimination (ADME) of these novel biopolymer-based nanomaterials in human body after administration by oral or parenteral route for therapeutic or diagnostic purpose. In vitro enzymatic degradation pathways should be investigated in order to yield commercially valuable oligomers. The goal of the present review is to enlighten on the ADME, cytotoxicity and in vitro enzymatic degradation of three marine sulfated polysaccharides, fucoidan, ulvan and mauran, obtained from brown seaweeds or macroalgae in the class of Phaeophyceae, members of Ulvales (green algae) and halophilic bacteria, respectively. They are presently being exploited in fabrication of nanoplatforms with novel applications in the field of controlled drug delivery, tissue regeneration scaffolds, cancer therapy, and bioimaging. However, significant research still needs to be carried out to characterize ADME of mauran and to improve production of the biopolymers on a large scale in order to find out clinically relevant solutions to establish these sulfated polysachharide-based nanotools as novel bionanotechnology strategies in future.

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Section: Cytotoxicity Of Marine Sulfated Polysaccharidesmentioning

confidence: 93%

Section: Marine Sulfated Polysaccharides As Bionanotechnology Platformsmentioning

confidence: 99%

Absorption, distribution, metabolism and elimination (ADME) and toxicity profile of marine sulfated polysaccharides used in bionanotechnology

Majee¹,

Avlani²,

Ghosh³

et al. 2018

Afr. J. Pharm. Pharmacol.

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“…Drug-loaded nanoparticles could kill the breast adenocarcinoma cells and glioma cells in a sustained and controlled manner (Raveendran et al, 2013;Raveendran et al, 2015). Magnetic nanoparticles coated with mauran have demonstrated biocompatibility and low cytocyoxicity towards normal cells.…”

Section: Pharmaceutical Uses Of Polysaccharidesmentioning

confidence: 99%

“…Doxorubicinloaded fucoidan-capped gold nanoparticles can be exploited as a contrast agent in imaging of breast cancer using photoacoustic imaging technique (Manivasagan et al, 2016). Mauran-chitosan nanoparticles labeled with fluorescein isothiocyanate (FITC) could act as safe and non-toxic vehicles for imaging of cancer cells by employing confocal microscopic imaging and flow cytometry (Raveendran et al, 2013;Balasubramanian et al, 2014;Raveendran et al, 2015).…”

Section: Diagnostic Applicationsmentioning

confidence: 99%

Pharmacological, pharmaceutical, cosmetic and diagnostic applications of sulfated polysaccharides from marine algae and bacteria

Majee¹,

Avlani²,

Biswas³

2017

Afr. J. Pharm. Pharmacol.

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Marine environment with rich biodiversity offer unlimited choice for novel biopolymers. Sulfated polysaccharides isolated from marine algae and bacteria constitute an important group in the marinederived biomolecules and biopolymers. They possess unique structural features which can be exploited to their fullest potential in the development of new therapeutic molecules, design of nanocarriers and stimuli-responsive drug delivery systems, development of anti-aging and moisturizing creams and as molecular probes in diagnosis of cancers and cardiovascular diseases. The aim of the present review is to highlight the sources, characteristics and applications of sulfated polysaccharides and exopolysaccharides isolated from marine algae, cyanobacteria, extremophilic and halophilic bacteria. Detailed description of physicochemical properties and versatile applications of ulvan, fucoidan, galactofucan sulfate, laminarin, mauran, cyanobacterial exopolysaccharides and other lesser known exopolysaccharides of marine bacterial origin has been provided. In a nutshell, it can be concluded that sustainable exploitation of the renewable, diverse library of these unique and novel sulfated polysaccharides will unravel newer possibilities in future and will enrich the existing arsenal of biopolymers.

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“…Para la preparación de nanopartículas de quitosano existen metodologías tales como coprecipitación, reticulación química, termodescomposición, coacervación, emulsificación y gelación iónica. Este último método es mayormente usado para la preparación de nanopartículas de polisacáridos (Raveendran et al, 2015). La técnica está basada en las interacciones iónicas entre los grupos aminos cargados positivamente del quitosano y los grupos cargados negativamen-te de un polianión, como por ejemplo el tripolifosfato de sodio (TPP), el cual es el agente iónico reticulador más ampliamente usado, debido a que no es tóxico y tiene la capacidad de gelificar rápidamente (Calvo et al, 1997; De Moura et al, 2009).…”

Section: Introductionunclassified

Generación de un protocolo para la síntesis de nanopartículas de quitosano cargadas con florfenicol a través del método de gelación iónica

Carmona¹,

Plaza²,

Recio‐Sánchez³

et al. 2018

Rev. investig. vet. Perú

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La formación de nanopartículas de quitosano mediante el método de gelación iónica tiene un alto potencial para la carga, transporte y liberación controlada de moléculas. Es un método sencillo y las nanopartículas presentan buena absorción, estabilidad, biocompatibilidad y baja toxicidad. El florfenicol es uno de los antibióticos más utilizados en la industria acuícola y es administrado mezclado con el alimento en altas concentraciones, lo cual genera problemas de dosis efectivas y de residuos no deseados. De esta manera, la síntesis de nanopartículas de quitosano (Q) cargadas con florfenicol podría otorgar ventajas a la hora de proteger, transportar y liberar de forma controlada el fármaco en peces de interés económico. En el presente estudio se sintetizaron nanopartículas de quitosano y tripolifosfato de sodio (TPP) con y sin florfenicol para evaluar su carga efectiva y liberación. Los resultados obtenidos con espectrometría FTIR corroboran la formación de las nanopartículas de Q-TPP con los cambios observados en los patrones de espectros infrarojo entre el quitosano matriz y las nanopartículas sintetizadas. Las nanopartículas de Q-TPP pueden cargar entre 48 y 50% de florfenicol en su interior. El ensayo de liberación in vitro del antibiótico mostró una liberación controlada y estable en el tiempo en condiciones de pH ácido y temperatura controlada de 15° C de hasta 10 días. Finalmente, se muestra que las nanopartículas de Q-TPP tienen potencial para atrapar y liberar de forma controlada el fármaco evaluado.

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Extremophilic polysaccharide nanoparticles for cancer nanotherapy and evaluation of antioxidant properties

Cited by 33 publications

References 46 publications

Absorption, distribution, metabolism and elimination (ADME) and toxicity profile of marine sulfated polysaccharides used in bionanotechnology

Absorption, distribution, metabolism and elimination (ADME) and toxicity profile of marine sulfated polysaccharides used in bionanotechnology

Pharmacological, pharmaceutical, cosmetic and diagnostic applications of sulfated polysaccharides from marine algae and bacteria

Generación de un protocolo para la síntesis de nanopartículas de quitosano cargadas con florfenicol a través del método de gelación iónica

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