Biocompatible Magnesium Alloys as Absorbable Implant Materials – Adjusted Surface and Subsurface Properties by Machining Processes

Denkena, Berend; Lucas, Arne

doi:10.1016/j.cirp.2007.05.029

Cited by 189 publications

(104 citation statements)

References 4 publications

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“…This leads to development of a large compressive residual stress deep into the subsurface of the workpiece (at a depth of 800 μm) in combination with sealing microcracks and pores in the surface, leading to increased corrosion resistance. For example, for Mg-3Ca alloy specimens immersed in 0.9 wt% NaCl solution, the corrosion rate (calculated from the hydrogen evolution results) of a DR specimen (rolling force: 200 N or 500 N) was <1% that of a turned specimen [69].…”

Section: Surface/subsurface Modification Methodsmentioning

confidence: 99%

Reduction in the Corrosion Rate of Magnesium and Magnesium Alloy Specimens and Implications for Plain Fully Bioresorbable Coronary Artery Stents: A Review

Lewis¹

2016

WJET

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The most popular treatment/management modality for coronary artery disease, which is one of the leading causes of death, is percutaneous transluminal coronary intervention (popularly known as "plain old balloon angioplasty") followed by implantation of a stent ("stenting"). Stent types have evolved from bare metal stents through first-generation drug-eluting stents to fully bioresorbable stents (FBRSs). Two examples of FBRSs are 1) Mg scaffold with no coating; and 2) Mg alloy scaffold coated with a bioresorbable polymer in which an anti-proliferative drug is embedded. In the case of Mg/Mg alloy FBRSs, one of the reported clinical results is that the resorption time of the stent is too short (<∼4 mo to ∼12 mo), a consequence of the high corrosion rate of the metal/alloy. The present review article contains 1) a summarized but comprehensive comparison and contrast of all the types of stents, with special reference to Mg/Mg alloy FBRSs; 2) a critical review of the body of literature on methods to reduce the corrosion rate of Mg/Mg alloy specimens in various aqueous biosimulating media that may have implications for plain Mg/Mg alloy FBRSs, examples of such methods being alloy chemistry modification and fabrication using a nanocomposite; and 3) directions for future work on Mg/Mg alloy FBRSs that draw upon the findings highlighted in item (2) above as well as on other ideas, such as utilization of a Mg matrix composite and fabrication using a metal additive manufacturing method. Thus, information given in this review may find use in work on decreasing the in vivo resorption time (and, hence, improving the clinical efficacy) of the current generation of fully-bioresorbable Mg/Mg-alloy stents as well as guide the development of the next generation of these stents.

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Section: Surface/subsurface Modification Methodsmentioning

confidence: 99%

Reduction in the Corrosion Rate of Magnesium and Magnesium Alloy Specimens and Implications for Plain Fully Bioresorbable Coronary Artery Stents: A Review

Lewis¹

2016

WJET

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“…Besides machining techniques for chip removal, the use of rolling operations can also generate high passive forces acting normal to the surface, which can induce work hardening of the sub-surface. During the rolling operation the sub-surface grain structure is changed by the compressive stresses induced and the resultant micro -topography of the surface is significantly changed [145]. A recent study by Denka et al has revealed a significant reduction in the corrosion rate (a factor of 100 was achieved in corrosion studies) of an Mg-Ca alloy that was deep-rolled, co mpared to the same alloy that was mach ined [146].…”

Section: Mechanical Modificati Ons To Induce Surface and Subsurface Pmentioning

confidence: 99%

Biomedical Magnesium Alloys: A Review of Material Properties, Surface Modifications and Potential as a Biodegradable Orthopaedic Implant

Poinern¹,

Brundavanam²,

Fawcett³

2013

AJBE

281

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Magnesium and magnesium based alloys are lightweight metallic materials that are extremely biocompatib le and have similar mechanical properties to natural bone. These materials have the potential to function as an osteoconductive and biodegradable substitute in load bearing applicat ions in the field of hard t issue engineering. However, the effects of corrosion and degradation in the physiological environ ment of the body has prevented their wide spread applicat ion to date. The aim o f this review is to examine the properties, chemical stability, degradation in situ and methods of improving the corrosion resistance of magnesium and its alloys for potential application in the orthopaedic field. To be an effective imp lant, the surface and sub-surface properties of the material needs to be carefully selected so that the degradation kinetics of the implant can be efficiently controlled. Several surface modification techniques are presented and their effectiveness in reducing the corrosion rate and methods of controlling the degradation period are discussed. Ideally, balancing the gradual loss of material and mechanical strength during degradation, with the increasing strength and stability of the newly forming bone tissue is the ultimate goal. If this goal can be achieved, then orthopaedic implants manufactured fro m magnesium based alloys have the potential to deliver successful clinical outcomes without the need for revision surgery.

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“…The properties can be adjusted by mechanical processing and it is known that these alterations have an influence on the component properties (Denkena et al, 2006a(Denkena et al, , 2008Tomac & Tonnessen, 1991;Tönshoff et al, 2007;Winkler, 2007). First investigations with biocompatible magnesium alloys already show promising results regarding biomechanical properties and the potential to adjust the corrosion behavior (Denkena et al, 2006b, Denkena & Lucas, 2007. However, the fundamental relations between the mechanical processing and the resulting surface and subsurface properties of biocompatible magnesium alloys have not yet been investigated.…”

Section: State Of Science and Technologymentioning

confidence: 99%

Biocompatible Magnesium Alloys as Degradable Implant Materials - Machining Induced Surface and Subsurface Properties and Implant Performance

Denkena¹,

Lucas²,

Thorey³

et al. 2011

Special Issues on Magnesium Alloys

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Biocompatible Magnesium Alloys as Absorbable Implant Materials – Adjusted Surface and Subsurface Properties by Machining Processes

Cited by 189 publications

References 4 publications

Reduction in the Corrosion Rate of Magnesium and Magnesium Alloy Specimens and Implications for Plain Fully Bioresorbable Coronary Artery Stents: A Review

Reduction in the Corrosion Rate of Magnesium and Magnesium Alloy Specimens and Implications for Plain Fully Bioresorbable Coronary Artery Stents: A Review

Biomedical Magnesium Alloys: A Review of Material Properties, Surface Modifications and Potential as a Biodegradable Orthopaedic Implant

Biocompatible Magnesium Alloys as Degradable Implant Materials - Machining Induced Surface and Subsurface Properties and Implant Performance

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