Biocompatible implant surface treatments

Pattanaik, Bikash; Pawar, Sudhir; Pattanaik, Seema

doi:10.4103/0970-9290.102240

Cited by 34 publications

(28 citation statements)

References 96 publications

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“…8 As the latest type of AM, selective laser melting (SLM) is widely used in biomedical implant fabrication. 9 Titanium and its alloys fabricated by SLM show great potential in individualized and customized implant manufacturing due to their biocompatibility and biomechanical properties. 10,11 Reports have shown evidence of good bone regeneration in SLM titanium specimens after surface modification in vivo and in vitro.…”

Section: Introductionmentioning

confidence: 99%

Micro-/nano-topography of selective laser melting titanium enhances adhesion and proliferation and regulates adhesion-related gene expressions of human gingival fibroblasts and human gingival epithelial cells

Xu¹,

Hu²,

Yu³

et al. 2018

IJN

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BackgroundSelective laser melting (SLM) titanium is an ideal option to manufacture customized implants with suitable surface modification to improve its bioactivity. The peri-implant soft tissues form a protective tissue barrier for the underlying osseointegration. Therefore, original microrough SLM surfaces should be treated for favorable attachment of surrounding soft tissues.Material and methodsIn this study, anodic oxidation (AO) was applied on the microrough SLM titanium substrate to form TiO2 nanotube arrays. After that, calcium phosphate (CaP) nanoparticles were embedded into the nanotubes or the interval of nanotubes by electrochemical deposition (AOC). These two samples were compared to untreated (SLM) samples and accepted mechanically polished (MP) SLM titanium samples. Scanning electron microscopy, energy dispersive spectrometry, X-ray diffraction, surface roughness, and water contact angle measurements were used for surface characterization. The primary human gingival epithelial cells (HGECs) and human gingival fibroblasts (HGFs) were cultured for cell assays to determine adhesion, proliferation, and adhesion-related gene expressions.ResultsFor HGECs, AOC samples showed significantly higher adhesion, proliferation, and adhesion-related gene expressions than AO and SLM samples (P<0.05) and similar exceptional ability in above aspects to MP samples. At the same time, AOC samples showed the highest adhesion, proliferation, and adhesion-related gene expressions for HGFs (P<0.05).ConclusionBy comparison between each sample, we could confirm that both anodic oxidation and CaP nanoparticles had improved bioactivity, and their combined utilization may likely be superior to mechanical polishing, which is most commonly used and widely accepted. Our results indicated that creating appropriate micro-/nano-topographies can be an effective method to affect cell behavior and increase the stability of the peri-implant mucosal barrier on SLM titanium surfaces, which contributes to its application in dental and other biomedical implants.

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Section: Introductionmentioning

confidence: 99%

Micro-/nano-topography of selective laser melting titanium enhances adhesion and proliferation and regulates adhesion-related gene expressions of human gingival fibroblasts and human gingival epithelial cells

Xu¹,

Hu²,

Yu³

et al. 2018

IJN

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“…(Un)Substituted anthranilic acid yielded corresponding 2‐chloromethyl‐4 H ‐benzoxazin‐4‐one ( 1a–c ) when treated with chloroacetyl chloride in the presence of dichloromethane (CH 2 Cl 2 ) by N ‐acylation via dehydrative cyclization mechanism . Condensation of 2‐chloromethyl‐4 H ‐benzoxazine‐4‐one derivatives with 2‐amino‐4‐(un)substitutedthiazole afforded the subsequent 2‐(thiazol‐2‐ylaminomethyl)‐4 H ‐benzoxazin‐4‐one ( 2a–f ) . Compounds 2a–f on heating at reflux with hydrazine monohydrate in alcoholic medium afforded the corresponding 3‐amino‐3 H ‐quinazolin‐4‐ones ( 3a–f ) in a good yield.…”

Section: Resultsmentioning

confidence: 99%

Design, Synthesis, and Biological Evaluation of Novel Quinazoline Clubbed Thiazoline Derivatives

Ali

Akhtar

Siddiqui

et al. 2017

Archiv der Pharmazie

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A novel series of quinazoline clubbed thiazoline derivatives was rationally designed and synthesized. The newly synthesized compounds were evaluated for in vitro dipeptidyl peptidase IV (DPP-4) inhibitory activity. Compounds that showed good to moderate activity were compared using linagliptin as standard. Compound 4x (IC = 1.12 nM) exhibited the most promising results. The special chemical feature of compound 4x also imparts good inhibition selectivity for DPP-4 over DPP-8/9. Moreover, docking of compound 4x into the active site of DPP-4 illustrates its possible binding interactions.

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“…Quinazolin-4-(3H)-one derivatives (43) were showed Anticonvulsant activity [57]. The 3,4-Dihydro-4-oxoquinazolin derivative (44,45) were exhibited anticonvulsant activity [58].…”

Section: Compound 40a-imentioning

confidence: 99%

“…A series of 3-aryl-2-(4 -arylthiazol-2 -yl aminomethyl)-quinazol in-4(3H)-ones (29) have been elicited for their impressive fungicidal activities [43].…”

Section: Compound 26mentioning

confidence: 99%

A Review on a Highly Important Hetrocycle Quinazolinone Compounds and their Diverse Biological Activities

2016

European Reviews of Chemical Research

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Quinazolinone and their derivatives have been studied extensively for various biological activities such as anti-inflammatory, antimicrobial, anticancer, anticonvulsant and anti-HIV activity etc. The purpose of this review was to collate literature work reported by researchers on quinazoline for their various pharmacological activities. Quinazolinone derivatives are one of the most active classes of compounds possessing a wide spectrum of biological activity. Recently several scientists have been reported that introduction of various heterocyclic moieties at quinazolinone nucleus modulate the activity. Various derivatives of quinazolinone have been synthesized and evaluated for their biological activities. This review might be helpful in the development of these novel lead molecules to potential drug candidates for future prospect.Keywords: Quinazoline, antimicrobial, Anti HIV, Anti cancer, biologically active. IntroductionHeterocyclic chemistry comprises at least half of all organic chemistry research worldwide. In particular, heterocyclic structures form the basis of many pharmaceutical, agrochemical and veterinary products. Quinazoline (1) are classes of fused heterocycles that are of considerable interest because of the diverse range of their biological activities such as, antimicrobial, anticancer, anticonvulsant, anti-tubercular, etc [1][2][3][4][5]. Quinazolin is a heterocyclic compound consists of two fused six membered simple aromatic rings, a benzene ring and a pyrimidine ring. The quinazolin nucleus has attracted the attention of medicinal chemists due to its well known anticancer activity, and many substituted quinazolin derivatives have recently earned great interest in chemotherapy as antitumor drugs [6]. Pharmacologically quinazolin particularly quinazolin-4-one (2) or quinazolinone are the most important classes of heterocyclic compounds. Quinazolin-4-one is synthesized when the keto group is introduced in the pyrimidine ring of quinazolin. Quinazolinone compounds possess versatile biological activities; such as anticancer [7][8]

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Biocompatible implant surface treatments

Cited by 34 publications

References 96 publications

Micro-/nano-topography of selective laser melting titanium enhances adhesion and proliferation and regulates adhesion-related gene expressions of human gingival fibroblasts and human gingival epithelial cells

Micro-/nano-topography of selective laser melting titanium enhances adhesion and proliferation and regulates adhesion-related gene expressions of human gingival fibroblasts and human gingival epithelial cells

Design, Synthesis, and Biological Evaluation of Novel Quinazoline Clubbed Thiazoline Derivatives

A Review on a Highly Important Hetrocycle Quinazolinone Compounds and their Diverse Biological Activities

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