Biocompatible High Entropy Alloys with Excellent Degradation Resistance in a Simulated Physiological Environment

Shittu, Jibril; Pole, Mayur; Cockerill, Irsalan; Sadeghilaridjani, Maryam; Reddy, L. J.; Manivasagam, Geetha; Singh, Harpreet; Grewal, Harpreet Singh; Arora, Harpreet Singh; Mukherjee, Sundeep

doi:10.1021/acsabm.0c01181

Cited by 43 publications

(20 citation statements)

References 53 publications

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“…Moreover, biocompatibility properties of the SLM product confirmed the highest cell density compared to cp-Ti, 316 L SS and near-equiatomic Ti 1.4 Nb 0.6 Ta 0.6 Zr 1.4 Mo 0.6 bio-HEA [ 41 ]. An excellent degradation resistance in a simulated physiological environment of bio-HEA MoNbTaTiZr alloy compared to 304 stainless steel (304 SS) was also reported in the literature by Shittu et al [ 42 ]. For equiatomic bio-HEA, the presence of dual-BCC phases was confirmed.…”

Section: Introductionsupporting

confidence: 55%

“…Additionally, studied high entropy alloy exhibited higher hardness, reduced Young’s modulus, wear resistance and biocompatibility in comparison to 304 SS. Taking the above into account, equiatomic MoNbTaTiZr high entropy composition exhibited promising applicability due to improved service life and low toxicity for the human body [ 42 ].…”

Section: Introductionmentioning

confidence: 99%

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Influence of Molybdenum on the Microstructure, Mechanical Properties and Corrosion Resistance of Ti20Ta20Nb20(ZrHf)20−xMox (Where: x = 0, 5, 10, 15, 20) High Entropy Alloys

et al. 2022

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The presented work was focused on investigating the influence of the (hafnium and zirconium)/molybdenum ratio on the microstructure and properties of Ti20Ta20Nb20(ZrHf)20−xMox (where: x = 0, 5, 10, 15, 20 at.%) high entropy alloys in an as-cast state. The designed chemical composition was chosen due to possible future biomedical applications. Materials were obtained from elemental powders by vacuum arc melting technique. Phase analysis revealed the presence of dual body-centered cubic phases. X-ray diffraction showed the decrease of lattice parameters of both phases with increasing molybdenum concentration up to 10% of molybdenum and further increase of lattice parameters. The presence of two-phase matrix microstructure and hafnium and zirconium precipitates was proved by scanning and transmission electron microscopy observation. Mechanical property measurements revealed decreased micro- and nanohardness and reduced Young’s modulus up to 10% of Mo content, and further increased up to 20% of molybdenum addition. Additionally, corrosion resistance measurements in Ringers’ solution confirmed the high biomedical ability of studied alloys due to the presence of stable oxide layers.

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Section: Introductionsupporting

confidence: 55%

Section: Introductionmentioning

confidence: 99%

Influence of Molybdenum on the Microstructure, Mechanical Properties and Corrosion Resistance of Ti20Ta20Nb20(ZrHf)20−xMox (Where: x = 0, 5, 10, 15, 20) High Entropy Alloys

et al. 2022

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“…The present study meets these targets on the basis of previous investigations regarding Mo-Nb-V-W-Ti high-entropy alloys [14], which have confirmed promising mechanical properties. Furthermore, several publications concerning the corrosive capabilities and degradation resistance [15][16][17] are considered to support our theories. In particular, alloys either based on, or at least containing high fractions of refractory metals, have shown favorable properties with regard to potential use in the field of biomedical materials [18][19][20].…”

Section: Introductionsupporting

confidence: 56%

“…Figure2. Calculated ∆H mix -δ plot, focusing on the solid solution phase section and comparing base alloy Ta-Nb-Ti to other relevant Bio-HEAs, from current investigations, data from[16,18,22,32].…”

mentioning

confidence: 99%

A Novel Alloy Development Approach: Biomedical Equiatomic Ta-Nb-Ti Alloy

Regenberg

Schmelzer

Hasemann

et al. 2021

Metals

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In the present manuscript, we report on the properties of an equiatomic Ta-Nb-Ti alloy as the basis for a novel, biomedical, multi-component alloy development. The alloy was produced using an arc melting furnace under Ar atmosphere, metallographically prepared, and investigated respectively. Furthermore, the alloy produced, as well as samples of elemental Ta, Nb, alloy Co-28Cr-6Mo, and alloy Ti-6Al-4V, were prepared with defined 1200 grit SiC grinding paper. The topography of the surfaces was evaluated using confocal microscopy and contact angle measurements subsequently. Afterwards, the biocompatibility of the novel alloy Ta-Nb-Ti was evaluated by means of cell (osteoblast) attachment as well as monocyte inflammatory response analysis. First results indicate competitive osteoblast attachment, as well as comparable expressions of fibrosis markers in comparison to conventionally used biomedical materials. In addition, the Ta-Nb-Ti alloy showed a markedly reduced inflammatory capacity, indicating a high potential for use as a prospective biomedical material.

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“…The large compositional design space of HEAs offers a unique flexibility to tailor their mechanical and functional properties for different applications. The core effects of high configurational entropy, lattice distortion, cocktail effect, and sluggish diffusion lead to a gamut of attractive mechanical, corrosion, and oxidation properties [328][329][330][331][332][333][334][335][336][337][338][339]. Therefore, they have been attracted as potential materials for advanced applications including aerospace, nuclear, cryogenics, and medical [340][341][342].…”

Section: High Entropy Alloys (Heas)mentioning

confidence: 99%

Review of Powder Bed Fusion Additive Manufacturing for Metals

Ladani

Sadeghilaridjani

2021

Metals

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Additive manufacturing (AM) as a disruptive technology has received much attention in recent years. In practice, however, much effort is focused on the AM of polymers. It is comparatively more expensive and more challenging to additively manufacture metallic parts due to their high temperature, the cost of producing powders, and capital outlays for metal additive manufacturing equipment. The main technology currently used by numerous companies in the aerospace and biomedical sectors to fabricate metallic parts is powder bed technology, in which either electron or laser beams are used to melt and fuse the powder particles line by line to make a three-dimensional part. Since this technology is new and also sought by manufacturers, many scientific questions have arisen that need to be answered. This manuscript gives an introduction to the technology and common materials and applications. Furthermore, the microstructure and quality of parts made using powder bed technology for several materials that are commonly fabricated using this technology are reviewed and the effects of several process parameters investigated in the literature are examined. New advances in fabricating highly conductive metals such as copper and aluminum are discussed and potential for future improvements is explored.

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Biocompatible High Entropy Alloys with Excellent Degradation Resistance in a Simulated Physiological Environment

Cited by 43 publications

References 53 publications

Influence of Molybdenum on the Microstructure, Mechanical Properties and Corrosion Resistance of Ti20Ta20Nb20(ZrHf)20−xMox (Where: x = 0, 5, 10, 15, 20) High Entropy Alloys

Influence of Molybdenum on the Microstructure, Mechanical Properties and Corrosion Resistance of Ti20Ta20Nb20(ZrHf)20−xMox (Where: x = 0, 5, 10, 15, 20) High Entropy Alloys

A Novel Alloy Development Approach: Biomedical Equiatomic Ta-Nb-Ti Alloy

Review of Powder Bed Fusion Additive Manufacturing for Metals

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