Biocompatible fabrication of TiO2 nanoparticles: Antimicrobial, anticoagulant, antiplatelet, direct hemolytic and cytotoxicity properties

Lingaraju, K.; Basavaraj, R.B.; Jayanna, K.; Bhavana, Sujana Mulk; Sannaningaiah, Devaraja; Kumaraswamy, H M; Nagaraju, G.; Nagabhushana, H.; Naika, H. Raja

doi:10.1016/j.inoche.2021.108505

Cited by 46 publications

(25 citation statements)

References 71 publications

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“…The biocompatibility of materials intended for use in the biomedical field must be appropriately evaluated. The hemolytic activity test is a reliable and scientific method for determining the biocompatibility of a synthetic material with living systems [ 42 ].…”

Section: Resultsmentioning

confidence: 99%

Formulation and Characterization of Poly (Ethylene Glycol)-Coated Core-Shell Methionine Magnetic Nanoparticles as a Carrier for Naproxen Delivery: Growth Inhibition of Cancer Cells

Yeganeh

Yousefi

et al. 2022

Cancers

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An efficient and selective drug delivery vehicle for cancer cells can remarkably improve therapeutic approaches. In this study, we focused on the synthesis and characterization of magnetic Ni1−xCoxFe2O4 nanoparticles (NPs) coated with two layers of methionine and polyethylene glycol to increase the loading capacity and lower toxicity to serve as an efficient drug carrier. Ni1−xCoxFe2O4@Methionine@PEG NPs were synthesized by a reflux method then characterized by FTIR, XRD, FESEM, TEM, and VSM. Naproxen was used as a model drug and its loading and release in the vehicles were evaluated. The results for loading efficiency showed 1 mg of Ni1−xCoxFe2O4@Methionine@PEG NPs could load 0.51 mg of the naproxen. Interestingly, Ni1−xCoxFe2O4@Methionine@PEG showed a gradual release of the drug, achieving a time-release up to 5 days, and demonstrated that a pH 5 release of the drug was about 20% higher than Ni1−xCoxFe2O4@Methionine NPs, which could enhance the intracellular drug release following endocytosis. At pH 7.4, the release of the drug was slower than Ni1−xCoxFe2O4@Methionine NPs; demonstrating the potential to minimize the adverse effects of anticancer drugs on normal tissues. Moreover, naproxen loaded onto the Ni1−xCoxFe2O4@Methionine@PEG NPs for breast cancer cell lines MDA-MB-231 and MCF-7 showed more significant cell death than the free drug, which was measured by an MTT assay. When comparing both cancer cells, we demonstrated that naproxen loaded onto the Ni1−xCoxFe2O4@Methionine@PEG NPs exhibited greater cell death effects on the MCF-7 cells compared with the MDA-MB-231 cells. The results of the hemolysis test also showed good hemocompatibility. The results indicated that the prepared magnetic nanocarrier could be suitable for controlled anticancer drug delivery.

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Section: Resultsmentioning

confidence: 99%

Formulation and Characterization of Poly (Ethylene Glycol)-Coated Core-Shell Methionine Magnetic Nanoparticles as a Carrier for Naproxen Delivery: Growth Inhibition of Cancer Cells

Yeganeh

Yousefi

et al. 2022

Cancers

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“…The significant current medical applications of TiO 2 NPs include their utilization as anticoagulant [ 255 ] wound dressings and skin tissue engineering [ 256 , 257 , 258 ]. The anticoagulant properties of these NPs inhibit the blood clot formation in the heart and brain, thus preventing their damage [ 255 ].…”

Section: The Titanium Oxide Npsmentioning

confidence: 99%

Medical and Dental Applications of Titania Nanoparticles: An Overview

Mansoor

Khurshid

Khan³

et al. 2022

Nanomaterials

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Currently, titanium oxide (TiO2) nanoparticles are successfully employed in human food, drugs, cosmetics, advanced medicine, and dentistry because of their non-cytotoxic, non-allergic, and bio-compatible nature when used in direct close contact with the human body. These NPs are the most versatile oxides as a result of their acceptable chemical stability, lower cost, strong oxidation properties, high refractive index, and enhanced aesthetics. These NPs are fabricated by conventional (physical and chemical) methods and the latest biological methods (biological, green, and biological derivatives), with their advantages and disadvantages in this epoch. The significance of TiO2 NPs as a medical material includes drug delivery release, cancer therapy, orthopedic implants, biosensors, instruments, and devices, whereas their significance as a dental biomaterial involves dentifrices, oral antibacterial disinfectants, whitening agents, and adhesives. In addition, TiO2 NPs play an important role in orthodontics (wires and brackets), endodontics (sealers and obturating materials), maxillofacial surgeries (implants and bone plates), prosthodontics (veneers, crowns, bridges, and acrylic resin dentures), and restorative dentistry (GIC and composites).

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“…), which also showed efficient anticoagulant activity. 219 Cola nitida (Sterculiaceae) extracts were also used to synthesize titanium oxide nanoparticles (TiO 2 NPs) that exhibited excellent anti-coagulant activity in vitro when observed on human blood. In addition, it was observed that these bioinspired titanium oxide nanoparticles maintained Fig.…”

Section: Therapeuticsmentioning

confidence: 99%

Potentialities of bioinspired metal and metal oxide nanoparticles in biomedical sciences

Singh¹,

et al. 2021

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Biocompatible fabrication of TiO2 nanoparticles: Antimicrobial, anticoagulant, antiplatelet, direct hemolytic and cytotoxicity properties

Cited by 46 publications

References 71 publications

Formulation and Characterization of Poly (Ethylene Glycol)-Coated Core-Shell Methionine Magnetic Nanoparticles as a Carrier for Naproxen Delivery: Growth Inhibition of Cancer Cells

Formulation and Characterization of Poly (Ethylene Glycol)-Coated Core-Shell Methionine Magnetic Nanoparticles as a Carrier for Naproxen Delivery: Growth Inhibition of Cancer Cells

Medical and Dental Applications of Titania Nanoparticles: An Overview

Potentialities of bioinspired metal and metal oxide nanoparticles in biomedical sciences

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