Biocompatible and multi-responsive poly(N-vinylcaprolactam)-based microgels: The role of acidic comonomers in the colloidal properties and phase transition as a function of temperature and pH

Medeiros, Sebastião Freitas de; Oliveira, P. M. S.; Silva, Taline M.; Lara, Bárbara R.; Elaı̈ssari, Abdelhamid; Santos, Amilton M.

doi:10.1016/j.eurpolymj.2015.10.008

Cited by 18 publications

(15 citation statements)

References 41 publications

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“…Although, the cell viability decreases as the concentration of the hydrogel samples increase, results are still relatively high with cell viability varying from 109% to 80% at 1.0 mg/mL. Medeiros et al synthesised chemically crosslinked P(NVCL-IA) microgels by precipitation polymerization [34]. The cytotoxicity of the gels were evaluated in-vitro by LDH leakage.…”

Section: Resultsmentioning

confidence: 99%

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Synthesis and Characterisation of Novel Temperature and pH Sensitive Physically Cross-Linked Poly(N-vinylcaprolactam-co-itaconic Acid) Hydrogels for Drug Delivery

Fallon

Halligan

Pezzoli

et al. 2019

Gels

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Previous studies involving poly N-vinylcaprolactam (PNVCL) and itaconic acid (IA) have synthesised the hydrogels with the presence of a solvent and a crosslinker, producing chemically crosslinked hydrogel systems. In this study, however, temperature sensitive PNVCL was physically crosslinked with a pH-sensitive comonomer IA through ultraviolet (UV) free-radical polymerization, without the presence of a solvent, to produce hydrogels with dual sensitivity. The attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy indicated successful polymerisation of the hydrogels. The temperature and pH sensitivity of the hydrogels was investigated. The lower critical solution temperature (LCST) of the gels was determined using the UV spectrometry and it was found that the incorporation of IA decreased the LCST. Rheology was conducted to investigate the mechanical and viscoelastic properties of the hydrogels, with results indicating IA that enhances the mechanical properties of the gels. Swelling studies were carried out at ~20 °C and 37 °C in different buffer solutions simulating the gastrointestinal tract (pH 2.2 and pH 6.8). In acidic conditions, the gels showed gradual increase in swelling while remaining structurally intact. While in basic conditions, the gels had a burst in swelling and began to gradually degrade after 30 min. Results were similar for drug release studies. Acetaminophen was incorporated into the hydrogels. Drug dissolution studies were carried out at 37 °C in pH 2.2 and pH 6.8. It was found that <20% of acetaminophen was released from the gels in pH 2.2, whereas the maximum drug released at pH 6.8 was 74%. Cytotoxicity studies also demonstrated the hydrogels to be highly biocompatible. These results indicate that physically crosslinked P(NVCL-IA) gels possess dual pH and temperature sensitive properties, which may be beneficial for biomedical applications such as drug delivery.

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Section: Resultsmentioning

confidence: 99%

“…This may be due to the presence of the crosslinker in the formulations. This is one disadvantage of using chemically crosslinked hydrogels for biomedical applications as crosslinkers can induce cytotoxicity [34].…”

Section: Resultsmentioning

confidence: 99%

Synthesis and Characterisation of Novel Temperature and pH Sensitive Physically Cross-Linked Poly(N-vinylcaprolactam-co-itaconic Acid) Hydrogels for Drug Delivery

Fallon

Halligan

Pezzoli

et al. 2019

Gels

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“…Aggregating microgels have also been synthesised by copolymerizing N-vinyl caprolactam (NVCL) with AA or itaconic acid (IA). 86 DLS data obtained at increasing temperatures displayed a decrease in the D h , as the microgels deswelled due to the thermoresponsive behaviour of PNVCL. The swelling ratio obtained from this data (ratio of D h at the highest and lowest temperature values) decreased when the concentration of AA or IA was increased.…”

Section: Temperature-and Ph-responsive Nanoparticle Aggregationmentioning

confidence: 97%

Multi-stimuli-responsive aggregation of nanoparticles driven by the manipulation of colloidal stability

et al. 2021

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“…Therefore, many studies about the thermoresponsive behavior as well as the possible applications of PNVCL-based polymers in the drug delivery system have been reported [ 6–8 ]. Furthermore, different structures of PNVCL-based polymers, i.e., micelles [ 9 ], hydrogels [ 10 ], microgels [ 11 ], as well as nanogels [ 12 , 13 ], have also been investigated as a carrier.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of dual-responsive poly(N-vinylcaprolactam-co-N-methylolacrylamide) nanogels

Nizardo

Alimin

Lestari

2022

Designed Monomers and Polymers

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This article reports the synthesis of poly(N-vinylcaprolactam-co-N-methylolacrylamide) (P(NVCL-co-NMA)) nanogels and investigates their thermo-/pH-responsive behavior. The formation of nanogels was synthesized using free radical emulsion polymerization by varying the monomer composition of NVCL:NMA, and their molecular structure was characterized by 1 H-NMR and FTIR. It was found that the nanogels were successfully prepared, and the nanogels exhibited LCST-type phase transition behavior. Cloud point transition temperature (T c ) was studied as a function of copolymer composition, MBA concentration, and pH of the solution by exploring their changes in turbidity using UV–vis spectrophotometer. Our studies reveal that T c nanogels increased with increasing concentration of NMA, which is due to the hydrophilicity of NMA. Our research also demonstrated that the increase in MBA percentage could decrease the T c of the synthesized nanogels. Interestingly, P(NVCL-co-NMA) nanogels showed not only a thermoresponsive behavior but also a pH response with increasing T c in a strong acidic environment owing to the H-bonds within the polymer chains. The results show that nanogels with initial monomer composition of NVCL and NMA of 75% and 25%, respectively, and using 4% of MBA showed T c around 35°C at pH 7.4. In addition, DLS studies also confirmed this result since the particle sizes became much larger after surpassing the temperature of 35°C. Due to this founding, such nanogels might have potential application in controlled release. Nevertheless, further studies regarding the adjustment of T c are still needed.

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Biocompatible and multi-responsive poly(N-vinylcaprolactam)-based microgels: The role of acidic comonomers in the colloidal properties and phase transition as a function of temperature and pH

Cited by 18 publications

References 41 publications

Synthesis and Characterisation of Novel Temperature and pH Sensitive Physically Cross-Linked Poly(N-vinylcaprolactam-co-itaconic Acid) Hydrogels for Drug Delivery

Synthesis and Characterisation of Novel Temperature and pH Sensitive Physically Cross-Linked Poly(N-vinylcaprolactam-co-itaconic Acid) Hydrogels for Drug Delivery

Multi-stimuli-responsive aggregation of nanoparticles driven by the manipulation of colloidal stability

Synthesis and characterization of dual-responsive poly(N-vinylcaprolactam-co-N-methylolacrylamide) nanogels

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