Biocompatible and biodegradable polyurethane polymers

Pavlova, M.; Draganova, M.

doi:10.1016/0142-9612(93)90196-9

Cited by 33 publications

(19 citation statements)

References 2 publications

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“…[1][2][3] Polyurethanes possess many of the attributes necessary for tissue-engineering applications, provided these materials can be synthesized into a composition that is biodegradable in vivo and that their degradation products are nontoxic. [4][5][6][7][8][9][10] In recent years, biodegradable polyesterurethane foams, synthesized with toluidine diisocyanate (TDI) and poly[(R)-3-hydroxybutyric acid-co-(R)-3-hydroxyvaleric acid]-diol (PHB/HV-diol) or polycaprolactone diol (PCL-diol), have been shown to be compatible substrates for chondrocytes and to support chondrocytic adhesion, cell proliferation, and phenotype, as assessed by collagen type II/I synthesis, in vitro. 11 Polyesterurethanes synthesized with lysine diisocyanate (LDI)-based hard segments and polyesters poly(Llactide) or 50:50 poly(lactide-co-glycolide) are biocompatible in vitro and in vivo.…”

Section: Introductionmentioning

confidence: 99%

Vascularization and tissue infiltration of a biodegradable polyurethane matrix

Ganta

Piesco

Long

et al. 2002

J Biomedical Materials Res

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Urethanes are frequently used in biomedical applications because of their excellent biocompatibility. However, their use has been limited to bioresistant polyurethanes. The aim of this study was to develop a nontoxic biodegradable polyurethane and to test its potential for tissue compatibility. A matrix was synthesized with pentane diisocyanate (PDI) as a hard segment and sucrose as a hydroxyl group donor to obtain a microtextured spongy urethane matrix. The matrix was biodegradable in an aqueous solution at 37°C in vitro as well as in vivo. The polymer was mechanically stable at body temperatures and exhibited a glass transition temperature (Tg) of 67°C. The porosity of the polymer network was between 10 and 2000 µm, with the majority of pores between 100 and 300 µm in diameter. This porosity was found to be adequate to support the adherence and proliferation of bone-marrow stromal cells (BMSC) and chondrocytes in vitro. The degradation products of the polymer were nontoxic to cells in vitro. Subdermal implants of the PDI-sucrose matrix did not exhibit toxicity in vivo and did not induce an acute inflammatory response in the host. However, some foreign-body giant cells did accumulate around the polymer and in its pores, suggesting its degradation is facilitated by hydrolysis as well as by giant cells. More important, subdermal implants of the polymer allowed marked infiltration of vascular and connective tissue, suggesting the free flow of fluids and nutrients in the implants. Because of the flexibility of the mechanical strength that can be obtained in urethanes and because of the ease with which a porous microtexture can be achieved, this matrix may be useful in many tissueengineering applications.

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Section: Introductionmentioning

confidence: 99%

Vascularization and tissue infiltration of a biodegradable polyurethane matrix

Ganta

Piesco

Long

et al. 2002

J Biomedical Materials Res

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“…In the last decade nonsegmented polyurethanes [5] which is usually the case when natural hydroxyl sources are used, have been synthesis for different purposes [6][7][8][9]. Polyurethanes are also recognized with their biocompatibility and biodegradation character [10] and hence have an important potential in wound dressing applications [11][12][13]. In literature it is emphasized that the chemistry of a polyurethane membrane has an important effect on biocompatibility [14].…”

Section: Introductionmentioning

confidence: 99%

Fatty acid-based polyurethane films for wound dressing applications

Gultekin

Atalay-Oral

Erkal

et al. 2008

J Mater Sci: Mater Med

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Fatty acid-based polyurethane films were prepared for use as potential wound dressing material. The polymerization reaction was carried out with or without catalyst. Polymer films were prepared by casting-evaporation technique with or without crosslink-catalyst. The film prepared from uncatalyzed reaction product with crosslink-catalyst gave slightly higher crosslink density. The mechanical tests showed that, the increase in the tensile strength and decrease in the elongation at break is due to the increase in the degree of crosslinking. All films were flexible, and resisted to acid solution. The films prepared without crosslink-catalyst were more hydrophilic, absorbed more water. The highest permeability values were generally obtained for the films prepared without crosslink catalyst. Both the direct contact method and the MMT test were applied for determination of cytotoxicity of polymer films and the polyurethane film prepared from uncatalyzed reaction product without crosslink-catalyst showed better biocompatibility property, closest to the commercial product, Opsite Ò .

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“…Due to the latter reason and due to the use of the silver flake ink for the screen-printed interconnects, the assembled unit fulfills biocompatibility requirements in a limited manner ( [29], [30]). Even though biocompatibility of substrate [31] is fulfilled, toxicity of the insulating mask [32] and encapsulation need to be considered carefully, when implemented within biomedical applications.…”

Section: Discussionmentioning

confidence: 99%

A Comprehensive Surface Mount Technology Solution for Integrated Circuits onto Flexible Screen Printed Electrical Interconnects

Akin¹,

Arias²

2014

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Biocompatible and biodegradable polyurethane polymers

Cited by 33 publications

References 2 publications

Vascularization and tissue infiltration of a biodegradable polyurethane matrix

Vascularization and tissue infiltration of a biodegradable polyurethane matrix

Fatty acid-based polyurethane films for wound dressing applications

A Comprehensive Surface Mount Technology Solution for Integrated Circuits onto Flexible Screen Printed Electrical Interconnects

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