Biocompatible and biodegradable poly(Tannic Acid) hydrogel with antimicrobial and antioxidant properties

Şahiner, Nurettin; Sagbas, Selin; Şahiner, Mehtap; Silan, Coşkun; Aktaş, Nahit; Türk, Mustafa

doi:10.1016/j.ijbiomac.2015.10.057

Cited by 156 publications

(97 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Figure 4b,c shows the results of the assay for Gram‐negative and ‐positive bacteria models, i.e., Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ), with 10 5 CFU mL −1 , respectively. After 24 h of incubation, the Groups FT‐2/8 and FT‐6/4 numbers for E. coli and S. aureus with different ratios of adhesive to bacterial suspension were significantly lower than those for the blank controls because of the existence of antibacterial TA in the adhesives . The highest adhesive‐to‐bacterial suspension ratio (200 mg mL −1 ) in Group FT‐2/8 was found to correspond to the most potent antibacterial ability to E. coli and S. aureus ; this might be attributed to the sample having the highest TA concentration.…”

mentioning

confidence: 93%

“…Additionally, developing SF‐based adhesives that are, e.g., convenient for synthesis, injection, and safety, which are highly desired for biomedical purposes, remains to be a challenge . Specifically, tannic acid (TA), which is a natural polyphenol compound with rich ester bonds and polyphenol groups, intrinsically exhibits biological properties of tissue adhesion, antioxidant capability, and antibiosis . It has demonstrated the potential to be a universal binder to induce gelation of some biomacromolecules, as the biomacromolecules tend to form complex amorphous structures owing to the strong noncovalent interactions between TA and the biomacromolecules …”

mentioning

confidence: 99%

“…In the adhesive group, the adhesive (Figure 4g) nearly completely sealed the wound, and most of the aligned structures were retained in the histological evaluations of the healed skin (Figure 4k), especially the generated epidermis, which was similar to normal tissue 4a,20. Since TA has been known to have the antibacterial ability and accelerate blood clotting, which are beneficial to wound healing . The better healing might be due to both the covering of the wound and also the existence of TA in the adhesives.…”

mentioning

confidence: 99%

See 2 more Smart Citations

A Highly Stretchable, Real‐Time Self‐Healable Hydrogel Adhesive Matrix for Tissue Patches and Flexible Electronics

Luo

Yang

Zheng

et al. 2020

Adv Healthcare Materials

View full text Add to dashboard Cite

The development of biocompatible self‐healable hydrogel adhesives for skin or wet, stretchable surfaces in air or under water is highly desirable for various biomedical applications ranging from skin patches to bioelectronics. However, it has been proven to be very challenging because most existing hydrogel adhesives are cytotoxic, or poorly adhere to dynamic or stretchable surfaces in wet environments. In this study, multifunctional hydrogel adhesives derived from silk fibroin (SF) and tannic acid (TA) are effectively constructed with high extensibility (i.e., up to 32 000%), real‐time self‐healing capability, underwater adhesivity, water‐sealing ability, biocompatibility, and antibiotic properties. According to all‐atom molecular dynamics simulation studies, the properties of the hydrogel adhesives, especially high extensibility, are mainly attributed to the hydrogen bonds between TA and the SF chains in water, and water and TA molecules can result in loose assemblies with fewer β‐sheets, and more random coils in the SF. Conductivity can also be easily introduced to the adhesive matrix and adjusted when the strain of the adhesives occurs. Considering that it has multiple functions and can be efficiently prepared, the proposed hydrogel adhesives have the potential for future medical applications, such as tissue adhesives and integrated bioelectronics.

show abstract

mentioning

confidence: 93%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

A Highly Stretchable, Real‐Time Self‐Healable Hydrogel Adhesive Matrix for Tissue Patches and Flexible Electronics

Luo

Yang

Zheng

et al. 2020

Adv Healthcare Materials

View full text Add to dashboard Cite

show abstract

“…Tannic acid has antioxidant and antimicrobial properties. [165] The TA use as an additive to a chitosan and collagen mixture (Figure 9) modifies the properties of the material. Moreover, it can be a potentially efficient barrier against some types of microorganisms.…”

Section: Tannic Acidmentioning

confidence: 99%

Chitosan/collagen blends with inorganic and organic additive—A review

Kaczmarek

Sionkowska

2017

Adv Polym Technol

View full text Add to dashboard Cite

This review provides a report on recent studies of composite materials based on a chitosan and collagen mixture due to their biocompatibility and bioactivity. Those natural polymers are most widely used to obtain biomaterials. However, the materials based on chitosan/collagen complexes present poor mechanical parameters, as well as high swelling behavior and enzymatic degradation rate. Such properties are considered problematic for the material clinical application. An increased interest in composite materials has been observed due to their enhanced physicochemical properties. A composite material preparation involves different compounds addition to natural polymers. Herein, the use of organic and inorganic additives has been reported. Moreover, the potential application of composite materials based on chitosan/ collagen complexes in the tissue engineering science has been discussed. K E Y W O R D Schitosan, collagen, composite materials, tissue engineering How to cite this article: Kaczmarek B, Sionkowska A. Chitosan/collagen blends with inorganic and organic additive-A review. Adv Polym Technol.

show abstract

“…However, most of the superabsorbent resin prepared from natural polymers do not have antibacterial properties. Sahiner et al (2015) used tannic acid to prepare a hydropghel polymer with antibacterial, antiviral, anticancer, anti-inflammatory and antioxidant properties.…”

Section: Introductionmentioning

confidence: 99%

Untitled

2017

IRJPEH

View full text Add to dashboard Cite

An antimicrobial superabsorbent was prepared by grafting polyacrylic acid on tara gum and adding chitosan quaternary ammonium salt (2-NHydroxypropyl-3-trimethylammonium chloride chitosan, HTCC). The effect of the amount of HTCC on swelling ratio of the product was investigated. The product was characterized by Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), and thermogravimetric analysis (TGA). The results showed that polyacrylic acid was successfully grafted on tara gum and a three-dimensional network structure was formed. The maximum swelling ratio in distilled water and 0.9 wt % NaCl solution reached 650 g/g and 65 g/g, respectively. The addition of HTCC increased the antibacterial property of superabsorbent against Staphylococcus aureus and Escherichia coli. The prepared antimicrobial superabsorbent will broaden the application field of tara gum and chitosan quaternary ammonium salt. This study provides a new path to prepare functional superabsorbent hydrogel.

show abstract

Biocompatible and biodegradable poly(Tannic Acid) hydrogel with antimicrobial and antioxidant properties

Cited by 156 publications

References 37 publications

A Highly Stretchable, Real‐Time Self‐Healable Hydrogel Adhesive Matrix for Tissue Patches and Flexible Electronics

A Highly Stretchable, Real‐Time Self‐Healable Hydrogel Adhesive Matrix for Tissue Patches and Flexible Electronics

Chitosan/collagen blends with inorganic and organic additive—A review

Untitled

Contact Info

Product

Resources

About