Biocompatibility Tests on the Intraocular Vision Aid Iova

Abstract

Intraocular miniaturized Image transmission Systems are developed to restore vision in patients with irreversible destruction of the anterior ocular segment (i.e. chemical burns, explosion trauma, trachoma) and high riskfor corneal transplantation, provided that the posterior ocular segment is intact. To ensure safety of such a device biocompatibility tests were conducted. In the present study the effects oflight and temperature in various intensities and the toxicity of the implanted materials on neural function in the rabbit retina in-vivo was investigated. All tests give encouraging results concerning the feasibility of intraocular miniaturized Image transmission Systems.

Surgical Results and Microscopic Analysis of the Tissue Reaction following Implantation and Explantation of an Intraocular Implant for Epiretinal Stimulation in Minipigs

“…This suggests -in accordance with a number of prior studies -biocompatibility of the materials used for encapsulation and electrode surface [11,[21][22][23] .…”

“…This receiver unit passes on the electromagnetic signal via a flexible cable to the stimulation electrodes, which are fixed to the macular region using 1 or 2 retinal tacks. In the course of development of this system, biocompatibility of the used materials inside the eye, feasibility of reversible epiretinal fixation via retinal tacks, viability of implantation as well as cortical activation triggered by the system via wireless activation could be shown, among other features [11][12][13] .…”

Elektronische Sehprothesen

“…Elektrisch inaktive Komponenten der Implantate wurden bei Kaninchen implantiert. Diese Materialproben wurden über eine Zeit von mindestens sechs Monaten gut vertragen [3].…”