Biocompatibility studies on surgical‐grade titanium‐, cobalt‐, and iron‐base alloys

Lemons, Jack E.; Niemann, Kurt M. W.; Weiss, A.

doi:10.1002/jbm.820100411

Cited by 49 publications

(18 citation statements)

References 6 publications

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“…It has a lower carbon content than SS 316 (a stainless-steel grade having 0.08% carbon) and offers excellent toughness to the overall bioimplant. SS 316L exhibits relatively good biocompatibility compared to SS316 [49,82]. It has much higher elastic modulus (about 200 GPa) than that of a typical human femur cortical bone (10-30 GPa) [11].…”

Section: Stainless Steel (Ss)mentioning

confidence: 99%

“…The excessive presence of these trace elements (Co, Cr, and Mo) has been reported to damage organs such as the kidney, liver, lungs, and also blood cells [92]. The elastic modulus and ultimate tensile strength of the Co-alloys are 200-230 GPa and 430-1028 MPa, respectively, which is approximately 10 times higher than that of a human bone [49]. Hence, the bioimplants manufactured from these materials may result in stress-shielding effect at a bioimplant-tissue interface [13].…”

Section: Cobalt (Co) Alloymentioning

confidence: 99%

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Materials for Orthopedic Bioimplants: Modulating Degradation and Surface Modification Using Integrated Nanomaterials

et al. 2020

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Significant research and development in the field of biomedical implants has evoked the scope to treat a broad range of orthopedic ailments that include fracture fixation, total bone replacement, joint arthrodesis, dental screws, and others. Importantly, the success of a bioimplant depends not only upon its bulk properties, but also on its surface properties that influence its interaction with the host tissue. Various approaches of surface modification such as coating of nanomaterial have been employed to enhance antibacterial activities of a bioimplant. The modified surface facilitates directed modulation of the host cellular behavior and grafting of cell-binding peptides, extracellular matrix (ECM) proteins, and growth factors to further improve host acceptance of a bioimplant. These strategies showed promising results in orthopedics, e.g., improved bone repair and regeneration. However, the choice of materials, especially considering their degradation behavior and surface properties, plays a key role in long-term reliability and performance of bioimplants. Metallic biomaterials have evolved largely in terms of their bulk and surface properties including nano-structuring with nanomaterials to meet the requirements of new generation orthopedic bioimplants. In this review, we have discussed metals and metal alloys commonly used for manufacturing different orthopedic bioimplants and the biotic as well as abiotic factors affecting the failure and degradation of those bioimplants. The review also highlights the currently available nanomaterial-based surface modification technologies to augment the function and performance of these metallic bioimplants in a clinical setting.

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Section: Stainless Steel (Ss)mentioning

confidence: 99%

Section: Cobalt (Co) Alloymentioning

confidence: 99%

Materials for Orthopedic Bioimplants: Modulating Degradation and Surface Modification Using Integrated Nanomaterials

et al. 2020

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“…The austenitic structure also offers this grade an excellent toughness, even down to cryogenic temperatures. According to the cytotoxicity evaluation standards, 316L stainless steels exhibit relatively good biocompatibility [10][11][12][13][14]. The first utilization of stainless steel in biological orthopaedics was reported in the 1930s, when Wiles [15,16] achieved the total hip replacement.…”

Section: Stainless Steelmentioning

confidence: 99%

State of the art of bioimplants manufacturing: part I

Kang

Fang

2018

Adv. Manuf.

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Bioimplants are becoming increasingly important in the modern society due to the fact of an aging population and associated issues of osteoporosis and osteoarthritis. The manufacturing of bioimplants involves an understanding of both mechanical engineering and biomedical science to produce biocompatible products with adequate lifespans. A suitable selection of materials is the prerequisite for a long-term and reliable service of the bioimplants, which relies highly on the comprehensive understanding of the material properties. In this paper, most biomaterials used for bioimplants are reviewed. The typical manufacturing processes are discussed in order to provide a perspective on the development of manufacturing fundamentals and latest technologies. The review also contains a discussion on the current measurement and evaluation constraints of the finished bioimplant products. Potential future research areas are presented at the end of this paper.

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“…Experiments were performed in triplicate. At selected time intervals (1,7,14,21, and 30 days), the number of cells on the samples were evaluated. Samples were then removed from the wells, rinsed with PBS, and placed in another 96-multiwell plate.…”

Section: Osteoblast-like Cell Growthmentioning

confidence: 99%

“…Consequently, extensive literature on osseointegration and related issues exists. [1][2][3] A shortened bone-healing period is desirable when an immediate implant procedure is applied without waiting period after tooth extraction. Despite success of cur-rently utilized implants, however, surface activation of titanium remains a very active area of research, as surface modification may induce acceleration of the bone healing phenomena.…”

Section: Introductionmentioning

confidence: 99%

Enhanced osteogenic promotion around dental implants with synthetic binding motif mimicking bone morphogenetic protein (BMP)‐2

Seol

Park

Lee

et al. 2006

J Biomedical Materials Res

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Synthetic receptor binding motif mimicking bone morphogenetic protein-2 (BMP-2) was covalently linked to titanium (Ti) surfaces through a chemical conjugation process. The composition and properties of surface-modified Ti were investigated by XPS as well as by measuring surface radioactivity. In vitro tests were conducted with osteoblast-like MC3T3-E1 cells to assess cell attachment, morphology, and expression of osteogenic marker in the cells grown on modified Ti surfaces. In addition, in vivo experiments involved implants in mandibular bone defects of beagles to evaluate the effect of surface modification on bone regeneration. Results of XPS measurements showed a complete and homogeneous peptide overlayer on the Ti surfaces; the content was further measured by gamma counting. Biological evaluations showed that the biochemically modified Ti samples were active in terms of cell attachment behavior. The MC3T3-E1 cell growth rate, marker protein expression, and alkaline phosphatase production of the peptide-modified surfaces were all higher than those of control Ti. Importantly, the implants in the canine mandibles showed significant increase of bone growth when modified with bioactive peptide, thereby confirming that biochemical modifications of Ti surfaces can enhance the rate of bone healing as compared with untreated Ti surfaces.

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Biocompatibility studies on surgical‐grade titanium‐, cobalt‐, and iron‐base alloys

Cited by 49 publications

References 6 publications

Materials for Orthopedic Bioimplants: Modulating Degradation and Surface Modification Using Integrated Nanomaterials

Materials for Orthopedic Bioimplants: Modulating Degradation and Surface Modification Using Integrated Nanomaterials

State of the art of bioimplants manufacturing: part I

Enhanced osteogenic promotion around dental implants with synthetic binding motif mimicking bone morphogenetic protein (BMP)‐2

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