Biocompatibility, physico-chemical and mechanical properties of hydroxyapatite-based silicon dioxide nanocomposites for biomedical applications

Taha, Mohammed A.; Youness, Rasha A.; Elhaes, Hanan

doi:10.1016/j.ceramint.2020.06.132

Cited by 49 publications

(20 citation statements)

References 43 publications

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“…Thus, microhardness, compressive strength, Young's modulus, elastic modulus, bulk modulus, shear modulus (G) and Poisson's ratio (ν) of all sintered nanocomposites were measured and represented in Figs. (2)(3)(4). All mechanical properties of the examined nanocomposites exhibit marked increases with successive increases in the BG content.…”

Section: Physical and Mechanical Propertiesmentioning

confidence: 93%

“…Additionally, the characteristic band of the Ag-O vibration mode near 565 cm − 1 is absent due to the same cause described above for SiO 2 . Since CHA has the major contribution to the studied nanocomposites, the characteristic bands for PO 4 3− , CO 3 2− and OH − groups appear. Of note, the partial decomposition of CHA and β-TCP phase formation can also be con rmed by FTIR spectroscopy.…”

Section: Ftir Spectral Analysismentioning

confidence: 99%

“…Figure 3 Young's modulus, elastic modulus, bulk modulus, shear modulus (G) and Poisson's ratio (ν) of all sintered nanocomposites were measured and represented in Figs. (2)(3)(4).…”

Section: Figurementioning

confidence: 99%

“…In addition, better biological properties can be obtained through the incorporation of carbonate (CO 3 ) 2− ions in its crystal structure forming carbonated hydroxyapatite (CHA). Furthermore, the preparation of HA in the nano-scale range also aids in improving the surface properties of HA [4,5]. Despite these wonderful characteristics, HA possesses poor mechanical properties along with a relatively slow bone bonding ability and its inability to prevent bacterial growth on its surface which lead to thinking of a solution to overcome these obstacles such as adding some elements or ceramics to enhance the abovementioned properties [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, Structural and Biomedical Characterization of Hydroxyapatite/Borosilicate Bioactive Glass Nanocomposites

Abulyazied

Alturki

Youness

et al. 2021

J Inorg Organomet Polym

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In this work, a borosilicate glass sample (5SiO -45B 2 O 3 -20Na 2 O-25CaO-5Ag 2 O) was added to nano-sized carbonated hydroxyapatite (CHA) powders with different contents up to 20 wt.% to improve the bioactivity, antibacterial effect, physical and mechanical properties of the resulting nanocomposites. Then, these samples were mixed, milled with a high-energy ball mill, sintered at 700°C and subjected to Xray diffraction (XRD) technique, Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopy (SEM) to examine their structure, chemical composition and microstructure, respectively. Furthermore, the physical and mechanical properties of the sintered nanocomposites were also measured. Moreover, the in vitro bioactivity of the prepared nanocomposites was examined with XRD and SEM. Additionally, the antibacterial behavior of these samples was tested against E. coli and S. aureus by the disc-diffusion method. The results obtained pointed out that the sample with the highest content of BG possessed the best bioactivity, antibacterial effect, physical and mechanical properties.

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Section: Physical and Mechanical Propertiesmentioning

confidence: 93%

Section: Ftir Spectral Analysismentioning

confidence: 99%

“…Figure 3 Young's modulus, elastic modulus, bulk modulus, shear modulus (G) and Poisson's ratio (ν) of all sintered nanocomposites were measured and represented in Figs. (2)(3)(4).…”

Section: Figurementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Synthesis, Structural and Biomedical Characterization of Hydroxyapatite/Borosilicate Bioactive Glass Nanocomposites

Abulyazied

Alturki

Youness

et al. 2021

J Inorg Organomet Polym

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“…Notably, there are various types of ball mill, which are necessary for MA, to perform the required fracture and welding process for powder particles bearing in mind that MA process is highly dependent upon the main parameters like milling time, speed, mill type, ball-to-powder (BPR) ratio and vial/ball material which consequently, control the size as well as shape of the produced reinforcing material [25][26][27]. Based on the abovementioned advantages of MA, this process is able to fabricate various MMCs with the desirable properties [28].…”

Section: Introductionmentioning

confidence: 99%

A comprehensive study of Al-Cu-Mg system reinforced with nano-ZrO2 particles synthesized by powder metallurgy technique

AbuShanab

Moustafa

Ghandourah

et al. 2021

Preprint

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Recently, increasing attention has been devoted to improving the various properties of aluminum alloys such as strength, elastic modulus, and coefficient of thermal expansion (CTE) as well as wear and corrosion by adding different percentages of ceramics for use in various industrial applications. In this sense, powder metallurgy technique has been used to fabricate Al-4.2 wt.% Cu-1.6 wt.% Mg matrix nanocomposites reinforced by different weight percentages of nano-ZrO2 particles. The microstructure and particle size distributions of the prepared powders were examined by SEM, TEM technique and diffraction particle size analyzer. The prepared powders were compacted and sintered in argon to obtain good sinterability. The physical, elastic and mechanical properties of the sintered nanocomposites were measured. Furthermore, thermal expansion, wear and corrosion behavior were also studied. The results showed that the decrease in the particle sizes of the Al-Cu-Mg alloy by adding ZrO2 nanoparticles up to 47.8 nm for the composite containing 16 wt.% ZrO2. With increasing the sintering temperature to 570 °C, the densification of nanocomposites was clearly enhanced. Also, the coefficient of thermal expansion and wear rate were remarkably decreases about 28 and 37.5 % with adding after adding 16 wt. % ZrO2. Moreover, microhardness yield, strength and Young’s modulus were enhanced to 161, 145 and 64%, respectively after adding 16 wt.% ZrO2. In addition, increasing the exposure time was responsible for decreasing the corrosion rate for the same sample.

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Combinatorial approach to fabricate silica doped polyvinyl alcohol/hydroxyapatite/carrageenan nanocomposite for bone regeneration applications

Fatima

Jolly

Mushahid

et al. 2023

Polymers for Advanced Techs

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Bone tissue engineering is a dominating approach for the fabrication of nanocomposite bone implants with superior biocompatibility and low toxicity to the surrounding tissues. Here, in this report ternary nanocomposites integrating nanohydroxyapatite/κ‐carrageenan/silica doped polyvinyl alcohol in three different ratios, that is, 60/30/10 (HCP1), 60/20/20 (HCP2), and 60/10/30 (HCP3) was constructed and a binary system comprised of nanohydroxyapatite and κ‐carrageenan was also prepared for analyzing and comparing their bone regeneration potential. The samples were characterized by various physico‐chemical techniques such as infra‐red spectroscopy, which furnished details about structural functionalities and complex formation. Rough surface morphology and dispersed particle size distribution of developed nanocomposites were revealed by scanning electron microscopy and electron transmission microscopy, respectively. Thermogravimetric analysis and differential temperature analysis revealed higher thermal stability of HCP3 nanocomposite with total weight loss of 10% and X‐ray diffraction analysis revealed average crystallite size of 15 nm for HCP3 nanocomposite. Bioactivity and biocompatibility of fabricated nanocomposites were deduced with the help of biological techniques. HCP3 manifested cell viability above 100% at 2 μg/mL concentration and exhibited hemolysis below 3% at all tested concentration favoring cell growth with minimum cytotoxicity. HCP3 also exhibited efficient apatite layer deposition, optimum swelling ability and improved biodegradability (~30%) and anti‐bacterial activity predicting it as a promising nanocomposite implant for future orthopedic applications.

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Biocompatibility, physico-chemical and mechanical properties of hydroxyapatite-based silicon dioxide nanocomposites for biomedical applications

Cited by 49 publications

References 43 publications

Synthesis, Structural and Biomedical Characterization of Hydroxyapatite/Borosilicate Bioactive Glass Nanocomposites

Synthesis, Structural and Biomedical Characterization of Hydroxyapatite/Borosilicate Bioactive Glass Nanocomposites

A comprehensive study of Al-Cu-Mg system reinforced with nano-ZrO2 particles synthesized by powder metallurgy technique

Combinatorial approach to fabricate silica doped polyvinyl alcohol/hydroxyapatite/carrageenan nanocomposite for bone regeneration applications

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Biocompatibility, physico-chemical and mechanical properties of hydroxyapatite-based silicon dioxide nanocomposites for biomedical applications

Cited by 49 publications

References 43 publications

Synthesis, Structural and Biomedical Characterization of Hydroxyapatite/Borosilicate Bioactive Glass Nanocomposites

Synthesis, Structural and Biomedical Characterization of Hydroxyapatite/Borosilicate Bioactive Glass Nanocomposites

A comprehensive study of Al-Cu-Mg&nbsp;system reinforced with nano-ZrO2 particles synthesized by powder metallurgy technique

Combinatorial approach to fabricate silica doped polyvinyl alcohol/hydroxyapatite/carrageenan nanocomposite for bone regeneration applications

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A comprehensive study of Al-Cu-Mg system reinforced with nano-ZrO2 particles synthesized by powder metallurgy technique