Biocompatibility performance evaluation of high flux hydrophilic CO3Ap/HAP/PSF composite membranes for hemodialysis application

Zaman, Shafiq Uz; ur‐Rehman, Saif; Zaman, Muhammad; Rafiq, Sikander; Muhammad, Nawshad; Saqib, Sidra; Jamal, Muddasar; Wajeeh, Salman; Imtiaz, Sania; Sadiq, Muhammad Tahseen

doi:10.1111/aor.13937

“…Good arteriovenous fistula is the key to determine the quality of dialysis and quality of life. Hemodialysis patients may lose confidence in treatment and affect prognosis due to long treatment cycle and irreversible course [ 3 , 4 ]. Clinically, whether some effective intervention measures can be used to improve the maintenance quality of arteriovenous fistula in hemodialysis patients and ultimately improve the quality of dialysis is considered, but there are few relevant literatures [ 5 , 6 ].. Studies have shown that the correct nursing is an important factor affecting the survival period of fistula [ 7 , 8 ]..…”

Section: Introductionmentioning

confidence: 99%

To Explore the Application of PDCA in Hemodialysis Center and Its Effect on the Maintenance of Internal Fistula

Su

¹

,

Cui

²

,

Pu

³

et al. 2022

BioMed Research International

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Background. The survey found that in recent years, with the incidence of chronic kidney disease (CKD) increasing, some patients with CKD even progressed to end-stage renal disease. Luckily, progressive hemodialysis technology and nursing level can improve the quality of life and prognosis of patients. Objective. To explore the application of plan-do-check-adjust (PDCA) cycle in the management of nurses in hemodialysis center and its effect on the maintenance of internal fistula in patients. Methods. In this study, a randomized controlled trail (RCT) was used to select 90 patients who underwent maintenance hemodialysis in the hemodialysis center of our hospital from January 2018 to June 2021 as objects. They were divided into a PDCA group (with PDCA nursing management) and routine group (with routine nursing management) by random number table with each of 45 cases for 6 months to compare the differences of the internal fistula complications, internal fistula maintenance quality, patients’ microinflammatory state, and satisfaction with nursing, as well as nursing staff’s operational and theoretical performance between the two groups. Results. There was no significant difference in CRP, IL-1, TNF-α, and IL-6 levels between the two groups before intervention ( P > 0.05 ); after that, these levels in the PDCA group were lower than those in the routine group, with statistically significant difference ( P < 0.05 ); before intervention, there was no statistically significant difference in the qualification rate of blood flow, the awareness rate of health education, and the incidence of nursing defects between the two groups ( P > 0.05 ); after that, the qualification rate of blood flow and the awareness rate of health education among nurses in PDCA group were higher than those in routine group, while the incidence of nursing defect accidents in the PDCA group was lower than that in routine group, and the differences were statistically significant ( P < 0.05 ); before intervention, there was no significant difference in the complication rate between the two groups ( P > 0.05 ); after that, the complication rate of the PDCA group was lower than that of the routine group, and the differences were statistically significant ( P < 0.05 ); after intervention, the theoretical assessment and practical skills assessment scores of the PDCA group were higher than those of the routine group, and the differences were statistically significant ( P < 0.05 ); after intervention, the nursing satisfaction of the PDCA group was higher than that of the routine group, and the differences were statistically significant ( P < 0.05 ). Conclusion. The application of PDCA approach in the management of nurses in hemodialysis centers can effectively improve the quality of internal fistula management and improve the practical and theoretical level of nurses, as well as reduce the microinflammation of patients.

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“…Reduction related to growth causes the REDOX indicator to change from oxidized (blue) form to reduced (red) form. After the measurements were taken, samples were fixated for other studies 22 …”

Section: Methodsmentioning

confidence: 99%

Fabrication and performance evaluation of polymeric membrane using blood compatible hydroxyapatite for artificial kidney application

Zaman

¹

,

Khan

²

,

Zaman

³

et al. 2021

Self Cite

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In the current study, a phase inversion scheme was employed to fabricate hydroxyapatite (HA)/polysulfone (PSF)‐based asymmetric membranes using a film applicator with water as a solvent and nonsolvent exchanging medium. Fourier Transform Infrared (FTIR) and X‐ray diffraction (XRD) spectroscopic studies were conducted to confirm the bonding chemistry and purity of filler. The inherent thick nature of PSF generated sponge‐like shape while the instantaneous demixing process produced finger‐like pore networks in HA/PSF‐based asymmetric membranes as exhibited by scanning electron microscope (SEM) micrographs. The FTIR spectra confirmed noncovalent weak attractions toward the polymer surface. The leaching ratio was evaluated to observe the dispersion behavior of HA filler in membrane composition. Hydrophilicity, pore profile, pure water permeation (PWP) flux, and molecular weight cutoff (MWCO) values of all formulated membranes were also calculated. Antifouling results revealed that HA modified PSF membranes exhibited 43% less adhesion of bovine serum albumin (BSA) together with >86% recovery of flux. Membrane composition showed 74% total resistance, out of which 60% was reversible resistance. Biocompatibility evaluation revealed that the modified membranes exhibited prothrombin time (PT), and thrombin time (TT) comparable with typical blood plasma, whereas proliferation of living cells over membrane surface proved its nontoxic behavior toward biomedical application. The urea and creatinine showed effective adsorption aptitude toward HA loaded PSF membranes.

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“…The ability of a material surface to act against the attachment of unwanted organisms Ag/ZnO/HA, 117 activated carbon (AC)/HA/polyethersulfone (PES), 118 boron nitrte (BN)/HA, 119 TiO 2 /HA, 120 Ag/nano-TiO 2 , 121 PES/polydopamine/taurine/HA membrane, 122 poly(vinylidene fluoride)(PVDP)/polyvinylpyrrolidone (PVP)/HA membrane, 123 PES/PVP/HA, 124 carbonate apatite/HA/polysulfone (PSF), 125 F/ HA/SiO 2 , 126 dentinal tubules (DTs), 127 zwitterionic polymers 128 and others 127,[129][130][131][132][133]…”

Section: Anti-foulingmentioning

confidence: 99%

Bioactive surface modifications through thermally sprayed hydroxyapatite composite coatings: a review of selective reinforcements

Jagadeeshanayaka

¹

,

Awasthi

²

,

Jambagi

³

et al. 2022

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Biocompatibility performance evaluation of high flux hydrophilic CO3Ap/HAP/PSF composite membranes for hemodialysis application

Cited by 11 publications

References 47 publications

To Explore the Application of PDCA in Hemodialysis Center and Its Effect on the Maintenance of Internal Fistula

To Explore the Application of PDCA in Hemodialysis Center and Its Effect on the Maintenance of Internal Fistula

Fabrication and performance evaluation of polymeric membrane using blood compatible hydroxyapatite for artificial kidney application

Bioactive surface modifications through thermally sprayed hydroxyapatite composite coatings: a review of selective reinforcements

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