Biocompatibility of silicone-coated oxygenator in cardiopulmonary bypass

Shimamoto, Akira; Kanemitsu, Shinji; Fujinaga, Kazuya; Takao, Motoshi; Onoda, Koji; Shimono, Takatsugu; Tanaka, Kuniyoshi; Shimpo, Hideto; Yada, Isao

doi:10.1016/s0003-4975(99)01113-3

Cited by 30 publications

(14 citation statements)

References 19 publications

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“…Polydimethylsiloxane (PDMS) has unique properties, such as low T g resulting in low temperature ductility, high thermal and oxidative stability, outstanding dielectric properties, and physiological inertness 1–4. However, pure siloxane polymers are rarely used without modification for technological applications; typically, they are modified with fillers, pigments, copolymerization, and curing agents to convert them to useful products, including rubbers and resins.…”

Section: Introductionmentioning

confidence: 99%

Effect of colloidal silica dispersions on the properties of PDMS‐colloidal silica composites

Dinkar¹,

Dhanabalan²,

Thimmappa

et al. 2012

J of Applied Polymer Sci

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Polydimethylsiloxane (PDMS) colloidal silica composites prepared with the use of the dispersion of colloidal silica (CS) of similar particle size and distribution in different mediums/solvents are investigated for their rheological, thermal, and mechanical properties. Regardless of the dispersion medium of CS, thermal analysis showed the increased thermal stability of PDMS with the addition of CS. The rheological analysis showed that the composites prepared from CS dispersed in isopropanol (IPA) and CS dispersed in methylethylketone (MEK) showed significant enhancement in viscosity at higher loadings as compare with the composite prepared from the CS dispersed in water and methanol indicating more Filler-polymer interactions. Similarly, the tensile stressstrain curves, hardness, and tear strength displayed significant improvement with PDMS-CS-MEK and PDMS-CS-IPA composites. The results of this study not only provide the insights of solid-liquid-liquid interface leading to different extent of polymer-filler interaction, there by the bulk properties, it also helps to minimize the surface treatment steps while preparing the composites. V C 2012 Wiley Periodicals, Inc. J Appl Polym Sci 125: E515-E522, 2012

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Section: Introductionmentioning

confidence: 99%

Effect of colloidal silica dispersions on the properties of PDMS‐colloidal silica composites

Dinkar¹,

Dhanabalan²,

Thimmappa

et al. 2012

J of Applied Polymer Sci

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“…This technique provides a unique and powerful method for changing surface properties by depositing a plasma layer while keeping the bulk structure of the treated material unchanged. Silicone elastomers 13 have already been used in such biomedical applications as catheters and contact lenses and more generally in the cardiopulmonary bypass, 14 in the development of an artificial cornea, 15 and in voice protheses. 16 They have been used in plasma treatment, [17][18][19] mainly in the field of membrane techniques.…”

Section: Introductionmentioning

confidence: 99%

Improvement of silicone endothelialization by treatment with allylamine and/or acrylic acid low‐pressure plasma

Monge

Mas

Hamzaoui

et al. 2003

J of Applied Polymer Sci

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Plasma polymerization of allylamine, acrylic acid, and an allylamine/acrylic acid mixture on Silastic silicone rubber led to a strong increase in the silicone rubber's hydrophilicity and surface energy. Analysis of the deposited layer by X-ray photoelectron spectroscopy with 20°and 70°takeoff angles showed segregation of the atoms according to the depth and the incorporation of amino groups, oxygenated groups, and both. The endothelialization of untreated and treated samples was evaluated by the seeding and growth of aorta epithelial cells from pigs in cellular adherence (%), doubling time (in hours), and confluent density (10 4 cells/cm 2 ). The best results were obtained with the allylamine/acrylic acid mixture treatment, which brought a biocompatibility to Silastic similar to classic tissue culture on polystyrene plates. The interpretation was based on the presence of NH 3 ϩ /CO 2Ϫ microareas in the deposited layer.

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“…different studies and ⁄ or institutions is extremely difficult because the magnitude of the inflammatory response is largely affected by the CPB management. Indeed, biocompatible materials, filters, pulsatility of flow, prime, cardiotomy suction and use of anti-inflammatory medications are all factors that affect the severity of the inflammatory response or its consequences [16][17][18][19]. In our institution, we routinely use biocompatible materials, filters, pulsatile flow and restrict cardiotomy suction.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary function and inflammatory markers in patients undergoing coronary revascularisation with or without cardiopulmonary bypass

Heijmans¹,

Liem²,

Damoiseaux³

et al. 2007

Anaesthesia

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SummaryLung injury after cardiac surgery is believed to result from cardiopulmonary bypass and its proinflammatory effects. To test this hypothesis, we compared the oxygenation ratios, extravascular lung water indices and systemic and pulmonary tumour necrosis factor alpha (TNF-a) and interleukin (IL)-8 at predetermined intervals in coronary artery surgery patients with or without cardiopulmonary bypass. No differences in oxygenation ratios or extravascular lung water indices were found. Serum values of TNF-a and IL-8 increased in both groups but were higher in the cardiopulmonary bypass group (end of surgery: mean (SD) TNF-a 3.68 (2.5) vs 2.20 (1.2) pg.ml Pulmonary dysfunction after cardiac surgery with cardiopulmonary bypass (CPB) is an important cause of postoperative morbidity [1]. The aetiology of this pulmonary impairment is believed to be multifactorial, occurring as a result of the combined effects of anaesthesia, surgery and CPB. CPB activates inflammatory processes, resulting in damage to lung parenchyma and increased pulmonary capillary permeability [2,3]. We therefore hypothesised that cardiac surgery with cardiopulmonary bypass (CPB group) may be associated with more postoperative pulmonary dysfunction than cardiac surgery without CPB (off-pump group). Recent studies comparing pulmonary dysfunction after cardiac surgery with or without CPB have produced conflicting evidence. However, markers of systemic and ⁄ or pulmonary inflammation were not measured in any of these studies [4][5][6][7][8]. These markers would provide evidence as to whether differences in lung dysfunction between the two groups are due to the inflammatory effects of CPB or to other interventional differences.The aim of this prospective study was to assess the inflammatory effect of CPB on postoperative pulmonary dysfunction. To compare the magnitude of pulmonary dysfunction, the oxygenation ratios and extravascular lung water indices were measured in two groups of patients undergoing coronary artery surgery with or without CPB. The inflammatory effects were assessed using the pro-inflammatory mediators interleukin (IL)-8 and tumour necrosis factor alpha (TNF-a), in blood and broncho-alveolar lavage (BAL) fluid. MethodsApproval of the hospital ethics committee and patients' written informed consent was obtained for this prospective study of 20 patients undergoing coronary artery surgery with cardiopulmonary bypass (CPB group) and 20 patients undergoing coronary artery surgery without CPB (off-pump group). Patients were not studied if they had left ventricular ejection fraction < 30%, recent

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Biocompatibility of silicone-coated oxygenator in cardiopulmonary bypass

Cited by 30 publications

References 19 publications

Effect of colloidal silica dispersions on the properties of PDMS‐colloidal silica composites

Effect of colloidal silica dispersions on the properties of PDMS‐colloidal silica composites

Improvement of silicone endothelialization by treatment with allylamine and/or acrylic acid low‐pressure plasma

Pulmonary function and inflammatory markers in patients undergoing coronary revascularisation with or without cardiopulmonary bypass

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