Biocompatibility of resin‐based dental materials applied as liners in deep cavities prepared in human teeth

Abstract

The resin-based dental cements VIT and UBP as well as the bonding agent CSEB presented acceptable biocompatibility when applied in deep cavities prepared in sound human teeth.

Evaluation of antibacterial and remineralizing nanocomposite and adhesive in rat tooth cavity model

“…The maxillary molar teeth and the surrounding bone were dissected, fixed in formalin (2.5%) and demineralized for 8 weeks with EDTA [47] Then the samples were exposed to ascending concentrations of alcohol (70, 90 and 100%), cleared in methyl salicilate and submerged in paraffin for 12 h [48] Sections with a thickness of 5 μm were cut in a buccolingual direction along the long axis of the tooth at every 50 μm. The sections were used for Haematoxylin and Eosin (H&E) staining and histological analysis [48] The sections were evaluated using a light microscope (Eclips e600, Nikon, Tokyo, Japan) to examine two types of histological features according to predefined criteria as stated in Tables 1 and 2, following previous reports [49,50]. Scoring was done in a blind manner; the first author scored the samples, and then a colleague in the oral histology field reexamined all samples.…”

Wnt/β-catenin signaling regulates Dental Pulp Stem Cells’ responses to pulp injury by resinous monomers

“…Among these influences, dental restorative procedures promoting the release of significant amounts of xenobiotics into the pulp cavity are one of the commonest injuries stimulating pulp repair responses [1]. Several previous studies have provided evidence about the cytotoxic effects of various compounds released by resinbased dental restorative materials, both in vitro [2,3] and vivo [4,5]. Of these, the resinous monomer TEGDMA (triethyleneglycol-dimethacrylate) has been extensively used as "model" substance for understanding the molecular mechanisms underlying pulp tissue responses, mainly due to its high release rate [6] and ability to diffuse through the dentinal tubules into the pulp cavity at toxic concentrations [7].…”

Transdentinal diffusion and cytotoxicity of self-etching adhesive systems

“…Lesser efforts have been dispended on the adequacy of their biological properties, though components derived from restoration/lining materials represent one of the aggressive elements to the pulp tissue subsequent to restorative procedures (Hanks et al 1988;de Souza Costa et al 2007). These components may be released through two preponderant mechanisms: (1) removal of non-reactive and/or residual monomers by solvent agents, following polymerization and (2) formation of components susceptible to removal by water as a result of degradation or erosion throughout time (Geurtsen 1998).…”