Biocompatibility of modified polyethersulfone membranes by blending an amphiphilic triblock co-polymer of poly(vinyl pyrrolidone)–b-poly(methyl methacrylate)–b-poly(vinyl pyrrolidone)

Ran, Fen; Nie, Shengqiang; Zhao, Weifeng; Li, Jie; Su, Baihai; Sun, Shudong; Zhao, Changsheng

doi:10.1016/j.actbio.2011.05.026

Cited by 196 publications

(118 citation statements)

References 81 publications

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“…In fact, in the past few years, there were many works reported on the modification of PES using block copolymers as additives. [14,17] Compared with these works, the present materials showed the similar even better cytocompatibility. [20,21] It should also be noted that the stability of the membrane especially the membrane surface was very good because of the use of comb-like block copolymer PVP-b-P(AE-g-PMMA)-b-PVP.…”

Section: Fluorescence Stainingsupporting

confidence: 46%

“…In our previous study, a PES membrane modified via synthesized amphiphilic triblock co-polymer of poly(vinyl pyrrolidone)-b-poly(methyl methacrylate)-b-poly(vinyl pyrrolidone) has been fabricated. [17] Besides the good hemocompatibility, the modified PES membrane also showed high cytocompatibility. The hepatocytes extended pseudopodia to adhere onto the material, and the viability of the cells on the modified membrane increased compared with the pristine membrane.…”

Section: Introductionmentioning

confidence: 98%

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Fabrication and cytocompatibility evaluation for blood-compatible polyethersulfone membrane modified by a synthesized poly (vinyl pyrrolidone)-block -poly (acrylate-graft -poly(methyl methacrylate))-block -poly-(vinyl pyrrolidone)

Ran

Song

et al. 2015

Polym. Adv. Technol.

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Polyethersulfone (PES) membrane, one of the most important polymeric materials because of its good chemical resistance, thermal stability, mechanical, and film-forming properties, has already been used in hemodialysis, tissue engineering, and artificial organs. In order to improve the blood compatibility of PES membrane, many amphiphilic block copolymers have been synthesized and used as additives for surface modification. The object of this study is to develop a hydrophilic PES membrane by blending a comblike amphiphilic block copolymer poly (vinyl pyrrolidone)-block-poly [acrylate-graft-poly (methyl methacrylate)]-block-poly-(vinyl pyrrolidone) [PVP-b-P (AE-g-PMMA)-b-PVP] synthesized by RAFT polymerization. The cytocompatibility performance of PVP-b-P (AE-g-PMMA)-b-PVP modified PES membrane was evaluated, which showed better cytocompatibility compared with that of pristine PES membrane. Endothelial cells cultured on the modified membranes present improved growth in terms of scanning electron microscope observation, MTT assay, and confocal laser scanning microscope observation. These results indicate that the modified membrane has great potential application in blood-contact fields such as hemodialysis and bio-artificial liver supports.

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Section: Fluorescence Stainingsupporting

confidence: 46%

Section: Introductionmentioning

confidence: 98%

Fabrication and cytocompatibility evaluation for blood-compatible polyethersulfone membrane modified by a synthesized poly (vinyl pyrrolidone)-block -poly (acrylate-graft -poly(methyl methacrylate))-block -poly-(vinyl pyrrolidone)

Ran

Song

et al. 2015

Polym. Adv. Technol.

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“…[321,322] MMA [323] MMA [324] AA [325] DMAm [326] (DMAm) [326] NIPAm [321] AA/St [327] NIPAm/ 361 [328] NIPAm/362 [328] MAA/ CHAm/NIPAm [328] MAA/BzAm/ NIPAm [328] MAA/OAm/ NIPAm [328] MAA/NIPAm/361 [328] AA/St-b-NVP [327] MAA/NIPAm/ 362 [328] MMA-b-(PEGMA/ NIPAm) [323] (NVP-b-MMA) [329,330] O I/M [285] St [285] BA [285] 81…”

mentioning

confidence: 99%

Living Radical Polymerization by the RAFT Process – A Third Update

2012

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This paper provides a third update to the review of reversible deactivation radical polymerization (RDRP) achieved with thiocarbonylthio compounds (ZC(¼S)SR) by a mechanism of reversible addition-fragmentation chain transfer ( Chem. 2009Chem. , 62, 1402. This review cites over 700 publications that appeared during the period mid 2009 to early 2012 covering various aspects of RAFT polymerization which include reagent synthesis and properties, kinetics and mechanism of polymerization, novel polymer syntheses, and a diverse range of applications. This period has witnessed further significant developments, particularly in the areas of novel RAFT agents, techniques for end-group transformation, the production of micro/nanoparticles and modified surfaces, and biopolymer conjugates both for therapeutic and diagnostic applications.

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“…Oleh karena itu, permeabilitas membran M3 dapat bertahan lebih lama dibandingkan dengan dua jenis membran lainnya yang murni bersifat hidrofobik. Sebagaimana hasil penelitian yang dipublikasikan oleh grup riset Ran (2011) dari Chiuan University, China, membran PES yang telah dimodifikasikan dengan PVP melalui proses kopolimerisasi mempunyai nilai water contact angle sekitar 58°, lebih rendah dari pada membran PES yang mempunyai water contact angle sekitar 75°. Ini menunjukkan bahwa membran campuran PES/PVP bersifat hidrofilik, karena memiliki water contact angle yang rendah.…”

Section: Permeabilitas Larutanunclassified

Profil Permeabilitas Berdasarkan Struktur Morfologi Membran Polietersulfon pada Pemekatan Larutan Tokoferol (Permeability Profile based on Morphology Structure of Polyethersulfone Membrane on Concentrating the Tocopherol Solution)

2017

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ABSTRAKTeknik separasi dengan membran teknologi telah diaplikasikan secara luas untuk pemisahan dan pemurnian komponen minor dari minyak tumbuh-tumbuhan. Membran telah dibuat dan dimodifikasikan dengan berbagai cara untuk meningkatkan kinerja filtrasi pada proses pemurnian minyak tumbuh-tumbuhan. Pada penelitian ini, dipelajari kinerja filtrasi tiga jenis membran hollow fiber yang terbuat dari polimer polietersulfon. Tujuan utama penelitian adalah untuk melihat pengaruh jenis membran terhadap kinerja filtrasi larutan tokoferol. Tiga seri penelitian ultrafiltrasi telah dirancang dengan menggunakan membran yang dibuat dengan melarutkan polietersulfon (PES) dalam N-metil pirolidon (NMP) dengan komposisi polimer yang berbeda. Ketiga jenis membran yang digunakan adalah M1 = PES 20 % + NMP, M2 = PES 18 % + NMP, dan M3 = PES 20 % + Polivinil pirolidon (PVP 5 %) + NMP. Perbedaan struktur morfologi membran telah dikonfirmasikan dengan analisis scanning electron microscopy. Profil permeabilitas larutan tokoferol 500 ppm diobservasi menggunakan modul tunggal membran hollow fiber dengan tipe aliran pressure driven inside (PDI). Hasil penelitian menunjukkan bahwa permeabilitas larutan tokoferol tertinggi dihasilkan dengan menggunakan membran M3. Lebih lanjut, peningkatan konsentrasi larutan tokoferol sekitar dua kali lebih tinggi dari konsentrasi awal dicapai dari proses filtrasi dengan membran M1.Kata kunci: Kinerja filtrasi; membran polietersulfon; permeabilitas larutan; larutan tokoferol ABSTRACT Separation technique by membrane technology has been widely applied for separation and purification of minor components from vegetable oil. Membrane was prepared and modified in several way in order to improve the filtration performance in purification process of vegetable oil. In this work, the filtration performance of three types of polyethersulfone hollow fiber membrane was investigated. The main objective of this research was to study the effect of membranes type on the filtration performance of tocopherol solution. Three series of filtration experiment were conducted by using fabricated membrane by dissolving of polyethersulfone (PES) in N-methyl pyrrolydone (NMP) with different polymer composition. The membranes was M1 = PES 20 % + NMP, M2 = PES 18 % + NMP, and M3 = PES 20 %+ Polyvinyl pyrrolidone (PVP 5 %) + NMP. The difference structure of membrans was confirmed by scanning electron microscopy measurement. The permeability profile of tocopherol solution of 500 ppm was observed by using a single module of hollow fiber membrane with filtration flow of pressure driven inside (PDI). It is shown that, the permeability of tocopherol solution was maximum and stable using PES membrane was composed by M3 system. Moreover, the improvement of tocopherol concentration in retentate solution was about two times higher than that the original solution that was obtained from filtration system of M1 membrane.

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Biocompatibility of modified polyethersulfone membranes by blending an amphiphilic triblock co-polymer of poly(vinyl pyrrolidone)–b-poly(methyl methacrylate)–b-poly(vinyl pyrrolidone)

Cited by 196 publications

References 81 publications

Fabrication and cytocompatibility evaluation for blood-compatible polyethersulfone membrane modified by a synthesized poly (vinyl pyrrolidone)-block -poly (acrylate-graft -poly(methyl methacrylate))-block -poly-(vinyl pyrrolidone)

Fabrication and cytocompatibility evaluation for blood-compatible polyethersulfone membrane modified by a synthesized poly (vinyl pyrrolidone)-block -poly (acrylate-graft -poly(methyl methacrylate))-block -poly-(vinyl pyrrolidone)

Living Radical Polymerization by the RAFT Process – A Third Update

Profil Permeabilitas Berdasarkan Struktur Morfologi Membran Polietersulfon pada Pemekatan Larutan Tokoferol (Permeability Profile based on Morphology Structure of Polyethersulfone Membrane on Concentrating the Tocopherol Solution)

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