Biocompatibility of mineral trioxide aggregate and three new endodontic cements: An animal study

Aminozarbian, m; Masoud, Barati; Salehi, Iman; Mousavi, Seyed Meysam

doi:10.4103/1735-3327.92944

Cited by 14 publications

(2 citation statements)

References 30 publications

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“…The materials used in endodontics, especially those used as root-end fillers, directly contact soft and hard periodontal tissues. Therefore, it is essential to adapt nontoxic and high-compatible substances [ 3 ]. Mineral Trioxide Aggregate (MTA) is a root-end filler material that was first developed by Torabinejad et al in 1995 at the University of Loma Linda [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Comparison of Rat Connective Tissue Response to BioMTA, Angelus MTA, and Root MTA

Alimohammadi

Mirzaee-Rad

Feizi

et al. 2021

International Journal of Biomaterials

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Due to the widespread use of MTA in dentistry and various brands of this product, we decided to compare the three brands available in the country market by their biocompatibility. We divided 20 male Wistar rats into four groups. After local anesthesia and washing, we made two incisions on both sides (4 incisions in total). The experimental groups were Angelus MTA (Angelus, Brazil), BioMTA (CERKAMED, Poland), Root MTA (Dr. Lotfi, Tabriz, Iran), and the control group. The resulting paste was placed in a tube and implanted subcutaneously into male Wistar rats. Wistar rats were sacrificed 7, 15, 30, and 60 days later, with high anesthetic doses. The sample implanted in 10% formalin was stabilized after tissue processing and H&E staining under a microscope. The inflammatory reaction in the tissues received different scores at the beginning of the tube opening. BioMTA had the highest inflammatory response among the groups, but the difference was not statistically significant ( p > 0.05). Also, there was no significant difference between the groups’ granulation and calcification ( p < 0.05). There was a significant difference between BioMTA, Angelus MTA, Root MTA, and control groups in fibrous capsule formation ( p < 0.05). Angelus MTA showed the lowest mean fibrous capsule formation in all periods. The effects of Angelus MTA, Root MTA, and BioMTA on connective tissue were investigated and compared. According to this study, these materials have good biocompatibility. According to the findings and statistical analysis, Angelus MTA has the most biocompatibility.

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Section: Introductionmentioning

confidence: 99%

Comparison of Rat Connective Tissue Response to BioMTA, Angelus MTA, and Root MTA

Alimohammadi

Mirzaee-Rad

Feizi

et al. 2021

International Journal of Biomaterials

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“…MTA Angelus can also stimulate the biomineralization process; it is also biocompatible and bioactive. [13][14][15][16] According to the manufacturer, the primary setting of this cement occurs within 15 minutes. This fast setting occurs due to the absence of sulfur and sudden hydration of tricalcium aluminate.…”

Section: Introductionmentioning

confidence: 99%

Chemical modification of MTA and CEM cement to decrease setting time and improve bioactivity properties by adding alkaline salts

Zavare

Nojehdehian

Moezizadeh

et al. 2020

J Dent Res Dent Clin Dent Prospects

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Background . Mineral trioxide aggregate (MTA) and Calcium-enriched Mixture (CEM) cement are used for pulp capping since they induce the formation of a dentinal bridge. Long setting time is a shortcoming of these types of cement. This study aimed to assess the effect of the incorporation of some alkaline salts to MTA and CEM cement on their setting time, ion release profile, pH, and surface morphology. Methods. In this in vitro experimental study, 5% calcium chloride (CaCl2), calcium oxide (CaO), sodium fluoride (NaF), and calcium nitrate [Ca(NO3)2] were separately added to MTA and CEM cement. The primary and final setting times of the cements were measured using a Gillmore needle apparatus. The samples were immersed in simulated body fluid (SBF) for one, seven, and 14 days and subjected to x-ray diffraction (XRD) and scanning electron microscopy (SEM) for phase identification and surface morphology assessment. The change in the pH of solutions was studied, and the calcium ion release profile was determined using inductively coupled plasma atomic emission spectroscopy (ICP-AES). The data were analyzed with ANOVA, followed by post hoc tests. Results. CaCl2 and CaO decreased the setting time of MTA, and Ca(NO3)2 decreased the setting time of CEM cement. The incorporation of the salts increased the pH and calcium ion release from both cements, and hydroxyapatite deposits were noted to cover the surface of the samples (observed by SEM and confirmed by EDXA). Conclusion. The incorporation of CaCl2 and CaO into MTA and Ca(NO3)2 into CEM cement decreased their setting time and increased their pH and calcium ion release.

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Morphological and immunohistochemical analysis of the biocompatibility of resin‐modified cements

Mesquita

Santos

Godoy

et al. 2016

Microscopy Res & Technique

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The aim of this double-blind randomized study was to evaluate the biocompatibility of resin-modified glass ionomer cements (RMGIC) by means of morphological and immunohistochemical analyses. RMGICs were selected and divided into four groups: Group CK (Crosslink Orthodontic Band Cement); Group RS (Resilience Light Cure Band Cement) Group RMO (RMO Band Cement), Group TP (Transbond Plus Light Cure Band), and Group C (Control-polyethylene). The materials were implanted in rat subcutaneous tissues, randomly selected for this study. After time intervals of 7, 15, and 30 days the tissues were submitted to morphological analysis. In immunohistochemical analysis, the immuno-marking of antibody CD68 was evaluated. The results obtained were statistically analyzed by the Kruskal-Wallis and Dunn tests (p < .05). In the morphological analysis after 7 days, Groups RS, RMO and TP showed more intense inflammatory infiltrate (p = .004) and only Group RMO presented greater intensity of multinucleated giant cells (p = .027). In the immunohistochemical analysis, Groups RMO and RS were observed to present a larger quantity of CD68+ (p = .004) in the time interval of 7 days and only Group RMO presented statistically significant difference for this parameter after 15 days (p = .026). In the time interval of 30 days, Group RMO presented the largest quantity of multinucleated giant cells (p < .004). The RMGICS Crosslink and Transbond Plus provided significantly better tissue biocompatibility than the Resilience and RMO Cements.

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Biocompatibility of mineral trioxide aggregate and three new endodontic cements: An animal study

Cited by 14 publications

References 30 publications

Comparison of Rat Connective Tissue Response to BioMTA, Angelus MTA, and Root MTA

Comparison of Rat Connective Tissue Response to BioMTA, Angelus MTA, and Root MTA

Chemical modification of MTA and CEM cement to decrease setting time and improve bioactivity properties by adding alkaline salts

Morphological and immunohistochemical analysis of the biocompatibility of resin‐modified cements

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