Biocompatibility of Mineral Trioxide Aggregate Mixed with Hydration Accelerators

Kang, Ji-Youn; Lee, Bin-Na; Son, Hye-Ju; Koh, Jeong‐Tae; Kang, Seong-Soo; Son, Ho-Hyun; Chang, Hoon-Sang; Hwang, In-Nam; Hwang, Yun-Chan; Oh, Won-Mann

doi:10.1016/j.joen.2012.11.037

Cited by 46 publications

(38 citation statements)

References 37 publications

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“…After that, distilled water or KY jelly was added to the previously prepared mixture using a pipette with a precision range of 5–10 μL (Eppendorf Research® plus, Hamburg, Germany). The experimental groups described below were prepared according to previous studies by using the method described above [21]. …”

Section: Methodsmentioning

confidence: 99%

Does Adding Various Accelerators to Mineral Trioxide Aggregate Have a Negatively Effect on Push-Out Bond Strength?

Ilker

Sarıyılmaz

Çakıcı³

2018

Med Princ Pract

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Objective: This study compares the effect of the white mineral trioxide aggregate (WMTA) accelerators, including disodium hydrogen orthophosphate (Na₂HPO₄; 2.5 wt%), calcium chloride (CaCl₂; 5 and 10 wt%), and KY jelly, on the push-out bond strength of WMTA. The null hypothesis was that the WMTA accelerators would not affect the push-out bond strength of WMTA. Materials and Methods: Slices (2-mm-thick) were obtained from 75 human mandibular molar distal roots. The slices were enlarged up to size 6 Gates-Glidden burs to obtain a 1.5-mm canal diameter. The slices were randomly divided into 4 experimental groups and a control group (n = 15 in each group). Freshly prepared WMTA mixture was placed into the root slices and stored at 37°C in a 100% humidified atmosphere for 60 days. The force required to dislodge the WMTA cement from the root slice was determined using a universal testing machine. The push-out bond strength was calculated. Results: Push- out bond strength of 5- and 10-wt% CaCl₂, and 2.5-wt% Na₂HPO₄ WMTA groups was significantly lower than in the KY-jelly and control groups (p < 0.05). The mean push-out bond strength of KY jelly was lower than in the control group but not statistically significant. Conclusion: The addition of KY jelly to WMTA did not have an adverse effect on the push-out bond strength of WMTA, in contrast to the other accelerators, including Na₂HPO₄ and CaCl₂, which reduced the push-out bond strength.

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Section: Methodsmentioning

confidence: 99%

Does Adding Various Accelerators to Mineral Trioxide Aggregate Have a Negatively Effect on Push-Out Bond Strength?

Ilker

Sarıyılmaz

Çakıcı³

2018

Med Princ Pract

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“…Hydration accelerators such as calcium chloride (CaCl 2 ), citric acid (CA), and calcium lactate gluconate solution (CLG) added to MTA showed favorable biocompatibility after 1 day. However, the association of MTA with 10 wt% CaCl 2 showed the lowest cell viability and poor cell attachment [ 94 ]. In addition, the effects of various additives on setting time and cell attachment on gray MTA (GMTA) were studied using osteoblasts and L929 mouse fi broblasts.…”

Section: Biocompatibilitymentioning

confidence: 99%

Properties of Hydrated Mineral Trioxide Aggregate

Tanomaru-Filho

Guerreiro-Tanomaru

2014

Mineral Trioxide Aggregate in Dentistry

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MTA has been currently commercialized in two different forms, the gray (GMTA) and the white version (WMTA). In particular, the white MTA was developed due to the potential discoloration promoted by the gray version of the cement. The chemical composition of the MTAs is very similar to that of Portland cement despite the addition of components containing bismuth in the MTA's cements [ 91 , 128 ], which aims to confer radiopacity to the materials [ 34 ]. The mixture of the MTA powder with distilled water results in the formation of by-products, such as calcium hydroxide and calcium silicate hydrate gel [ 27 , 28 ] as discussed in Chap. 2 . The particular mechanism of hydration and the structure of the set material result in particular properties displayed by the set MTA.The initial pH of the MTA is approximately 10.2, but it increases to 12.5 after 3 h immersed in solution [ 177 ]. MTA has the ability to sustain high values of pH during long periods [ 75 ]. The high pH values exhibited by MTA are attributed to the constant release of calcium and the formation of calcium hydroxide.Several studies had reported release of calcium from MTA [ 12 , 74 , 131 ]. The calcium ion release is enhanced when calcium chloride is added as an accelerator to MTA [ 12 ]. Moreover, when MTA was placed into the root canals of teeth with simulated radicular resorption, a greater calcium ion release was detected in comparison to teeth not fi lled with MTA [ 131 ]. Setting TimeThe hydration of the MTA powder produces a colloidal gel, which solidifi es and results in a solid structure. MTA is prepared by mixing the powder with distilled water using a ratio of 3:1 (powder/distilled water) [ 184 ].

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“…It is composed mainly of Portland cement, with bismuth oxide included as a radiopacifier. It suffers the drawback of a long setting time; however, there have been many attempts to overcome this through the addition of chemical accelerators [14][15][16][17] . Although the setting time of MTA with additives is shorter than that of the original form of MTA, the reported setting time is still too long to reflect clinical significance.…”

Section: Introductionmentioning

confidence: 99%

“…Although the setting time of MTA with additives is shorter than that of the original form of MTA, the reported setting time is still too long to reflect clinical significance. Moreover, various studies have shown that adding additives to MTA to shorten its setting time may have adverse effects on its physical and biological properties [17][18][19] . Meanwhile, a fast-setting calcium-silicate cement (Endocem, Maruchi, Wonju, Korea) was introduced in the endodontic market.…”

Section: Introductionmentioning

confidence: 99%

Odontogenic effects of a fast-setting calcium-silicate cement containing zirconium oxide

et al. 2015

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A fast-setting calcium-silicate cement (Endocem) was introduced in the field of dentistry for use in vital pulp therapy. Similar to mineral trioxide aggregate (MTA), it contains bismuth oxide to provide radiopacity. Recently, another product, EndocemZr, which contains zirconium oxide (ZrO2) as a radiopacifier, was developed by the same company. In this study, the biological/odontogenic effects of EndocemZr were investigated in human primary dental pulp cells (hpDPCs) in vitro and on capped rat teeth in vivo. The biocompatibility of EndocemZr was similar to that of ProRoot and Endocem on the basis of cell viability tests and cell morphological analysis. The mineralization nodule formation, expression of odontogenic-related markers, and reparative dentin formation of EndocemZr group was similar to those of other material groups. Our results suggest that EndocemZr has the potential to be used as an effective material for vital pulp therapy, similar to ProRoot and Endocem.

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Biocompatibility of Mineral Trioxide Aggregate Mixed with Hydration Accelerators

Cited by 46 publications

References 37 publications

Does Adding Various Accelerators to Mineral Trioxide Aggregate Have a Negatively Effect on Push-Out Bond Strength?

Does Adding Various Accelerators to Mineral Trioxide Aggregate Have a Negatively Effect on Push-Out Bond Strength?

Properties of Hydrated Mineral Trioxide Aggregate

Odontogenic effects of a fast-setting calcium-silicate cement containing zirconium oxide

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