Biocompatibility of intraocular lens power adjustment using a femtosecond laser in a rabbit model

Werner, Liliana; Ludlow, Jason; Nguyen, Jason; Aliancy, Joah; Ha, Larry; Masino, Bryan; Enright, Sean; Alley, R.; Sahler, Ruth; Mamalis, Nick

doi:10.1016/j.jcrs.2017.05.040

Cited by 11 publications

(9 citation statements)

References 11 publications

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“…It appears to induce chemical changes in the IOL substrate which affect its refractive index, without affecting the overall modulation transfer function of the IOL and is biocompatible in a rabbit model. [106][107][108] This application of FL technology has yet to be performed in vivo on a human but may allow refining the post-operative refraction including toricity or multifocality.…”

Section: Future Applications Of Flacs Under Current Investigationmentioning

confidence: 99%

Femtosecond laser–assisted cataract surgery: A review

Roberts,

Day,

O’Brart

2019

European Journal of Ophthalmology

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Purpose: Review scientific literature concerning femtosecond laser–assisted cataract surgery. Methods: Following databases were searched: CENTRAL (Cochrane Eyes and Vision Trials Register; Cochrane Library: Issue 2 of 12, June 2019), Ovid MEDLINE® without Revisions (1996 to June 2019), Ovid MEDLINE® (1946 to June 2019), Ovid MEDLINE® Daily Update June 2019, MEDLINE and MEDLINE Non-Indexed Items, Embase (1980–2019), Embase (1974 to June 2019), Ovid MEDLINE® and Epub Ahead of Print, in-Process & Other Non-Indexed Citations and Daily (1946 to June 2019), Web of Science (all years), the metaRegister of Controlled Trials ( www.controlled-trials.com ), ClinicalTrials.gov ( www.clinicaltrial.gov ) and World Health Organization International Clinical Trials Registry Platform ( www.who.int/ictrp/search/en ). Search terms/keywords included ‘Femtosecond laser’ combined with ‘cataract’, ‘cataract surgery’. Results: Based on quality of their methodology and their originality, 121 articles were reviewed, including randomised controlled trials, cohort studies, case-controlled studies, case series, case reports and laboratory studies. Each step of the femtosecond laser–assisted cataract surgery procedure (corneal incisions, arcuate keratotomies, capsulotomy and lens fragmentation) has been discussed with relevance to published outcomes, as well as complication rates of femtosecond laser–assisted cataract surgery, and what we can learn from the larger studies/meta-analyses and the economics of femtosecond laser–assisted cataract surgery within different healthcare settings. Conclusion: Studies suggest that the current clinical outcomes of femtosecond laser–assisted cataract surgery are not different to conventional phacoemulsification surgery and it is not cost effective when compared with conventional phacoemulsification surgery. In its current technological form, it is a useful surgical tool in specific complex cataract scenarios, but its usage has not been shown to translate into better clinical outcomes.

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Section: Future Applications Of Flacs Under Current Investigationmentioning

confidence: 99%

Femtosecond laser–assisted cataract surgery: A review

Roberts,

Day,

O’Brart

2019

European Journal of Ophthalmology

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“…Under slit lamp examination, the phase-wrapped structure created by the laser could be observed within the optic substance of all treated IOLs. The examination also showed the formation of gas bubbles between the posterior surface of the IOL and the posterior capsule, which disappeared within 5 h. Other observa- No aqueous flare, cells, iris hyperemia, or fibrin formations were observed at any of the post-laser slit lamp examinations, and the process did not create glistening's in the IOLs [34,35]. The consistency and precision of the power changes induced by the laser have been shown in vitro.…”

Section: Biocompatibility Of Intraocular Lens Power Adjustmentmentioning

confidence: 64%

Refractive Index Shaping: In Vivo Optimization of an Implanted Intraocular Lens (IOL)

Sahler¹,

Bille

2019

High Resolution Imaging in Microscopy and Ophthalmology

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“…FSL is also suggested to enable an adjustment of IOL power by increasing hydrophilicity of the target areas within the optic, creating a refractive index shaping lens within an existing IOL [110,111]. An in vitro study revealed that a negative refractive index change in the laser-treated optic areas resulting from the change in hydrophilicity might be the chemical basis for an alteration of the IOL power [112].…”

Section: Experimental Studies Regarding Potential Application Of the mentioning

confidence: 99%

“…An experimental study using a hydrophobic acrylic IOL revealed that power adjustment using FSL produced a reliable refractive change [111]. An animal study also showed that IOL power adjustment using FSL might be a precise, reliable, and biocompatible method for the correction of refractive error after cataract surgery [110].…”

Section: Experimental Studies Regarding Potential Application Of the mentioning

confidence: 99%

Application of Femtosecond Laser in Anterior Segment Surgery

Han

Liu

Mohamed-Noriega

2020

Journal of Ophthalmology

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Femtosecond laser (FSL) is a near-infrared laser that can create reliable and reproducible tissue cutting with minimal damage to adjacent tissue. As the laser can also create incisions with various orientations, depths, and shapes, it is expected to be a useful tool for anterior segment surgery, such as cornea, refractive, and cataract surgery. In this review, the authors will introduce the application of FSL in various anterior segment surgeries and discuss the results of studies regarding the efficacy and safety of FSL in cornea, refractive, and cataract surgery. Experimental studies regarding the potential use of FSL will also be introduced. The studies discussed in this review suggest that FSL may be a useful tool for improving the prognosis and safety of surgeries of the anterior segment.

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Biocompatibility of intraocular lens power adjustment using a femtosecond laser in a rabbit model

Abstract: Consistent and precise power changes can be induced in the optic of commercially available IOLs in vivo by using a femtosecond laser to create a refractive-index shaping lens. The laser treatment of the IOLs was biocompatible.

Cited by 11 publications

References 11 publications

Femtosecond laser–assisted cataract surgery: A review

Femtosecond laser–assisted cataract surgery: A review

Refractive Index Shaping: In Vivo Optimization of an Implanted Intraocular Lens (IOL)

Application of Femtosecond Laser in Anterior Segment Surgery

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