Biocompatibility of engineered nanoparticles for drug delivery

Naahidi, Sheva; Jafari, Mousa; Edalat, Faramarz; Raymond, Kevin P.; Khademhosseini, Ali; Chen, P.

doi:10.1016/j.jconrel.2012.12.013

Cited by 644 publications

(414 citation statements)

References 173 publications

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“…62 Some studies discussed immune system stimulation by methacrylate nanoparticles. 20,[62][63][64][65][66] Although IL-12 stimulation by nanostructures without peptide has been observed (Figure 4), this same stimulus was not observed when nanostructures were associated with clavanin, probably because clavanin A suppresses the effect as shown in Figure 4. Furthermore, it is important to report that besides IL-12 stimulation by nanostructures without peptide, no cytotoxic effects against erythrocytes were observed.…”

Section: Immunologic In Vitro Assaysmentioning

confidence: 99%

Clavanin bacterial sepsis control using a novel methacrylate nanocarrier

Saúde¹,

Ombredane²,

Silva³

et al. 2014

IJN

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Controlling human pathogenic bacteria is a worldwide problem due to increasing bacterial resistance. This has prompted a number of studies investigating peptides isolated from marine animals as a possible alternative for control of human pathogen infections. Clavanins are antimicrobial peptides isolated from the marine tunicate Styela clava , showing 23 amino acid residues in length, cationic properties, and also high bactericidal activity. In spite of clear benefits from the use of peptides, currently 95% of peptide properties have limited pharmaceutical applicability, such as low solubility and short half-life in the circulatory system. Here, nanobiotechnology was used to encapsulate clavanin A in order to develop nanoantibiotics against bacterial sepsis. Clavanin was nanostructured using EUDRAGIT ® L 100-55 and RS 30 D solution (3:1 w:w). Atomic force, scanning electron microscopy and dynamic light scattering showed nanoparticles ranging from 120 to 372 nm in diameter, with a zeta potential of -7.16 mV and a polydispersity index of 0.123. Encapsulation rate of 98% was assessed by reversed-phase chromatography. In vitro bioassays showed that the nanostructured clavanin was partially able to control development of Staphylococcus aureus , Klebsiella pneumoniae , and Pseudomonas aeruginosa . Furthermore, nanostructures did not show hemolytic activity. In vivo sepsis bioassays were performed using C57BL6 mice strain inoculated with a polymicrobial suspension. Assays led to 100% survival rate under sub-lethal sepsis assays and 40% under lethal sepsis assays in the presence of nanoformulated clavanin A until the seventh day of the experiment. Data here reported indicated that nanostructured clavanin A form shows improved antimicrobial activity and has the potential to be used to treat polymicrobial infections.

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Section: Immunologic In Vitro Assaysmentioning

confidence: 99%

Clavanin bacterial sepsis control using a novel methacrylate nanocarrier

Saúde¹,

Ombredane²,

Silva³

et al. 2014

IJN

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“…B. Nanopartículas orgánicas como los liposomas, las micelas, los dendrímeros, los conjugados de proteínas y las poliméricas es ventajosa para su uso; sin embargo, esas mismas características y propiedades hacen que, cuando una NP se introduce en el organismo, el sistema inmunitario la reconozca como un agente extraño y se produzca una respuesta inmune (19,20). Además, factores como la dosis y la vía de administración, el mecanismo de acción y el sitio de la actividad -que son propiedades extrínsecas al material-también son críticos en el establecimiento de la respuesta inmune (12,21). Por esta razón, se han reportado múltiples efectos inmunomoduladores mediados por las NP en diferentes componentes de la respuesta inmune (12).…”

Section: Actividad Inmunomoduladora De Diferentes Nanopartículasunclassified

“…Como parte de la inmunoestimulación, las NP han mostrado propiedades adyuvantes (potenciadoras de la respuesta inmune), incluso en el contexto del cáncer, favoreciendo la eliminación de tumores secundarios refractarios al tratamiento (12). Además, se han descrito múltiples modificaciones a las NP, que les confieren efectos específicos sobre la respuesta inmune, pero que no serán consideradas en esta revisión, pues dichos efectos se asocian directamente con estas modificaciones.…”

Section: Actividad Inmunomoduladora De Diferentes Nanopartículasunclassified

“…Entre los desarrollos más importantes de la nanomedicina se encuentran sistemas de diagnóstico para la detección temprana de enfermedades (8-10), recubrimientos para mejorar la biocompatibilidad de implantes o prótesis, aditivos para mejorar la solubilidad y biodisponibilidad de fármacos (11,12), materiales para ingeniería tisular, medicina regenerativa y biomiméticos (13)(14)(15), sistemas de encapsulación, transporte y administración dirigida y controlada de fármacos y genes a tejidos o células específicas (6,9,(11)(12)(13)15,16), adyuvantes para vacunas (11) y terapias antitumorales (7,17), entre otras.…”

Section: Introductionunclassified

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Efecto inmunomodulador de nanopartículas usadas en nanomedicina

Gómez-Gallego

Urcuqui-Inchima

Hernández

2016

iatreia

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RESUMENLas nanopartículas (NP) son estructuras con tamaño en la escala nanométrica (1 x 10 -9 m). Por sus características, en los últimos años ha crecido su potencial para usarlas en los campos biotecnológico y biomédico en una amplia gama de aplicaciones, tales como el diagnóstico, la terapia y la medicina regenerativa.El sistema inmunológico es el responsable de la defensa del cuerpo ante organismos patógenos y otros agentes extraños, como las NP, que pueden ser reconocidas por dicho sistema, interactuar con él y modular su función induciendo efectos inmunosupresores o inmunoestimuladores. Las primeras se podrían utilizar como agentes terapéuticos antinflamatorios o para tratar las enfermedades autoinmunes, y las que activan el sistema inmune, como adyuvantes en vacunación o potenciadores de la respuesta inmune en cáncer y otras enfermedades humanas. Sin embargo, su uso en nanomedicina debe estar sujeto a ensayos previos que determinen su efecto en la respuesta inmune antes de aplicarlas a los sistemas biológicos. Por esta razón es importante conocer su composición, tamaño y características superficiales, entre otras propiedades fisicoquímicas, directamente implicadas en los efectos sobre el sistema inmune. Se presenta una visión general de la relación entre las propiedades fisicoquímicas de las NP candidatas para ser usadas en los campos biomédico y biotecnológico y su actividad inmunomoduladora. PALABRAS CLAVEInmunomodulación; Nanomedicina; Nanopartículas SUMMARYImmunomodulating effect of nanoparticles used in nanomedicine Nanoparticles (NP) are structures with a size on the nanometer scale (1 x 10 -9 m). Due to their characteristics, their potential use in the fields of biotechnology and biomedicine has grown in

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“…Maynard has estimated that the production of engineered nanomaterials will reach 58,000 tons between 2011 and 2020, which represents a large increase from the 2004 estimate of only 2000 tons [2]. Nanoparticles are used in a wide range of products for biomedicine, cosmetics, electronics, environmental technologies, pharmaceuticals and textiles [3][4][5][6][7]. In the field of photodynamic therapy, photosensitizers have been linked to silica nanoparticles in order to combine their photophysical and biological properties [8], for conditioning the uptake into target cells.…”

Section: Introductionmentioning

confidence: 99%

Polymerization of Vinylpyrrolidone to Form a Neutral Coating on Anionic Nanomaterials in Aqueous Suspension for Rapid Sedimentation

Lai

Nour

2014

Coatings

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Nanomaterials in water present an array of identifiable potential hazards to ecological and human health. There is no general consensus about the influence of anionic or cationic charge on the toxicity of nanomaterials on environmental ecology. One challenge is the limited number of scalable technologies available for the removal of charged nanomaterials from water. A new method based on polymer coating has been developed in our laboratory for rapid sedimentation of nanomaterials in aqueous suspension. Using colloidal silica as a model inorganic oxide, coating of polyvinylpyrrolidone (PVP) around the SiO 2 nanoparticles produced SiO 2 @PVP particles, as indicated by a linear increase of nephelometric turbidity. Purification of the water sample was afforded by total sedimentation of SiO 2 @PVP particles when left for 24 h. Characterization by capillary electrophoresis (CE) revealed nearly zero ionic charge on the particles. Further coating of polydopamine (PDA) around those particles in aqueous suspension produced an intense dark color due to the formation of SiO 2 @PVP@PDA. The SiO 2 @PVP@PDA peak appeared at a characteristic migration time of 4.2 min that allowed for quantitative CE-UV analysis to determine the original SiO 2 concentration with enhanced sensitivity and without any ambiguous identity.

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Biocompatibility of engineered nanoparticles for drug delivery

Cited by 644 publications

References 173 publications

Clavanin bacterial sepsis control using a novel methacrylate nanocarrier

Clavanin bacterial sepsis control using a novel methacrylate nanocarrier

Efecto inmunomodulador de nanopartículas usadas en nanomedicina

Polymerization of Vinylpyrrolidone to Form a Neutral Coating on Anionic Nanomaterials in Aqueous Suspension for Rapid Sedimentation

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