Efecto inmunomodulador de nanopartículas usadas en nanomedicina

Gómez-Gallego, Diana Maryory; Urcuqui-Inchima, Silvio; Hernández, Juan Carlos

doi:10.17533/udea.iatreia.v29n4a06

Cited by 3 publications

(1 citation statement)

References 81 publications

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“…SiNPs have been used in nanobiotechnology for various applications, such as controlled drug/gene delivery matrices, biosensors, diagnostic imaging and tissue engineering. 3,30,31 However, SiNPs can induce immune responses affecting their safe use for human applications.…”

Section: Discussionmentioning

confidence: 99%

Silica nanoparticles induce NLRP3 inflammasome activation in human primary immune cells

2017

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In recent years, the potential use of silica nanoparticles (SiNPs) among different biomedical fields has grown. A deep understanding of the physicochemical properties of nanoparticles (NPs) and their regulation of specific biological responses is crucial for the successful application of NPs. Exposure to NP physicochemical properties (size, shape, porosity, etc.) could result in deleterious effects on cellular functions, including a pro-inflammatory response mediated via activation of the NLRP3 inflammasome. The aim of this study was to evaluate the potential in vitro immunomodulatory effect of 12-nm and 200-nm SiNPs on the expression of pro-inflammatory cytokines and NLRP3 inflammasome components in human primary neutrophils and PBMCs. This study demonstrates that regardless of the size of the nanoparticles, SiNPs induce the production of pro-inflammatory cytokines in a dose-dependent manner. Induced IL-1β production after exposure to SiNPs suggests the involvement of NLRP3 inflammasome components participation in this process. In conclusion, SiNPs induce the production of pro-inflammatory cytokines in a dose-dependent manner. Furthermore, our data suggest that the production and release of IL-1β possibly occurs through the formation of the NLRP3 inflammasome.

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Section: Discussionmentioning

confidence: 99%

Silica nanoparticles induce NLRP3 inflammasome activation in human primary immune cells

2017

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Effects of particulate matter on endothelial, epithelial and immune system cells

Cano-Granda

Ramírez-Ramírez

Gómez-Gallego

et al. 2022

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Particulate Matter (PM) is an air pollutant that is classified according to its aerodynamic diameter into particles with a diameter of less than 10 µm (PM10), a diameter of less than 2.5 µm (PM2.5), and particles ultra-fine with a diameter less than 0.1 µm (PM0.1). PM10 is housed in the respiratory system, while PM2.5 and 0.1 can pass into the circulation to generate systemic alterations. Although several diseases associated with PM exposure, such as respiratory, cardiovascular, and central nervous system, have been documented to cause 4.2 million premature deaths per year worldwide. Few reviews address cellular and molecular mechanisms in the epithelial and endothelial cells of the tissues exposed to PM, which can cause these diseases, this being the objective of the present review. For this, a search was carried out in the NCBI and Google Scholar databases focused on scientific publications that addressed the expression of pro-inflammatory molecules, adhesion molecules, and oxidative radicals, among others, and their relationship with the effects caused by the PM. The main findings include the increase in pro-inflammatory cytokines and dysfunction in the components of the immune response; the formation of reactive oxygen species; changes in epithelial and endothelial function, evidenced by altered expression of adhesion molecules; and the increase in molecules involved in coagulation. Complementary studies are required to understand the molecular effects of harmful health effects and the future approach to strategies to mitigate this response.

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Sistema inmune innato e infección por SARS-CoV-2. Revisión sistemática

Coutiño Rodríguez

2023

Rev Alerg Mex

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Debido a la infección por SARS-CoV-2, la respuesta no controlada ni regulada del sistema inmune innato puede provocar daño orgánico local y multisistémico, que es característico en pacientes que ingresan a los hospitales y fallecen por causa del virus. Este estudio revisa algunos de los factores implicados con los cuadros patológicos graves de la infección, principalmente en hombres, de artículos publicados entre 2010 y 2021, y libros especializados. La investigación muestra que la edad, el sexo, la raza y el grupo sanguíneo (específicamente el A), aunados a diversos factores (inmunosenescencia y comorbilidades), son decisivos en la gravedad de la enfermedad. Finalmente, se plantea que, aunque los hombres y mujeres tienen la misma probabilidad de padecer COVID-19, los hombres tienen mayor posibilidad de morir, puesto que poseen más receptores ACE2 en plasma, mayor actividad de esterasas, producen más citocinas proinflamatorias y responden diferente a las hormonas (la testosterona favorece más la respuesta inmune innata mientras que los estrógenos a la adaptativa) y a los efectos de los inhibidores de dopamina implicados en la respuesta inflamatoria. Además, los andrógenos regulan al receptor TMPRSS e inducen metaloproteasas implicadas en procesos fibróticos y de adhesión.

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Efecto inmunomodulador de nanopartículas usadas en nanomedicina

Cited by 3 publications

References 81 publications

Silica nanoparticles induce NLRP3 inflammasome activation in human primary immune cells

Silica nanoparticles induce NLRP3 inflammasome activation in human primary immune cells

Effects of particulate matter on endothelial, epithelial and immune system cells

Sistema inmune innato e infección por SARS-CoV-2. Revisión sistemática

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