Biocompatibility of choline salts as crosslinking agents for collagen based biomaterials

Vijayaraghavan, R.; Thompson, Brianna C.; MacFarlane, Douglas R.; Kumar, Ramadhar; Surianarayanan, M.; S, Aishwarya; Sehgal, Praveen Kumar

doi:10.1039/b910601d

Cited by 95 publications

(90 citation statements)

References 31 publications

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“…[24][25][26] This is mostly due to the fact that choline (more correctly cholinium) is a naturally occurring cation that shows very low toxicity and it can work as a cell signaling agent. 27,28 Choline salts have also been used recently in IL-gel systems for cancer therapy delivery. 29 Choline nitrate, [Ch][NO3], is chosen in this work due to its low viscosity, high conductivity and biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

Biocompatible Ionic Liquid–Biopolymer Electrolyte-Enabled Thin and Compact Magnesium–Air Batteries

Jia

Yang

Wang

et al. 2014

ACS Appl. Mater. Interfaces

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103

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With the surge of interest in miniaturized implanted medical devices (IMDs), implantable power sources with small dimensions and biocompatibility are in high demand. Implanted battery/supercapacitor devices are commonly packaged within a case that occupies a large volume, making miniaturization difficult. In this study, we demonstrate a polymer electrolyte-enabled biocompatible magnesium-air battery device with a total thickness of approximately 300 μm. It consists of a biocompatible polypyrrole-para(toluene sulfonic acid) cathode and a bioresorbable magnesium alloy anode. The biocompatible electrolyte used is made of choline nitrate (ionic liquid) embedded in a biopolymer, chitosan. This polymer electrolyte is mechanically robust and offers a high ionic conductivity of 8.9 x 10-3 S cm-1. The assembled battery delivers a maximum volumetric power density of 3.9 W L-1, which is sufficient to drive some types of IMDs, such as cardiac pacemakers or biomonitoring systems. This miniaturized, biocompatible magnesium-air battery may pave the way to a future generation of implantable power sources. Abstract:With the surge of interest in miniaturized implanted medical devices (IMDs), implantable power sources with small dimensions and biocompatibility are in high demand. Implanted battery/supercapacitor devices are commonly packaged within a case that occupies a large volume making miniaturization difficult. In this study, we demonstrate a polymer electrolyte enabled biocompatible magnesium-air battery device with a total thickness of approximately 300 µm. It consists of a biocompatible polypyrrole-para(toluene sulfonic acid) cathode and a bioresorbable magnesium alloy anode. The biocompatible electrolyte used is made of choline nitrate (ionic liquid) embedded in a biopolymer, chitosan. This polymer electrolyte is mechanically robust and offers a high ionic conductivity of 8.9×10 -3 S cm -1 . The assembled battery delivers a maximum volumetric power density of 3.9 W L -1 , which is sufficient to drive some types of IMDs such as cardiac pacemakers or bio-monitoring systems. This miniaturized, biocompatible magnesium-air battery may pave a way to the future generation of implantable power sources.

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Section: Introductionmentioning

confidence: 99%

Biocompatible Ionic Liquid–Biopolymer Electrolyte-Enabled Thin and Compact Magnesium–Air Batteries

Jia

Yang

Wang

et al. 2014

ACS Appl. Mater. Interfaces

Self Cite

103

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“…Choline formate (CF), choline levulinate (CL), choline nitrate (CN), choline tartrate (CT), choline valproate (CV), choline aminoacetate (CAAc) and choline gallate (CG) were synthesised by neutralisation reaction of the selected acidic form of the anion with choline hydroxide, following the procedure described elsewhere. 19,29 Choline dihydrogen phosphate ionic liquid buffer (CDHP/B) was synthesised as described elsewhere. 30 It typically involves the addition of 6.30 g (0.5 mol) of choline hydroxide (20 wt% in water) in a beaker containing 4.02 g of dry CDHP (1 mol), with stirring at room temperature until it becomes a clear solution.…”

Section: Chemicalsmentioning

confidence: 99%

“…cell cultures or in vivo applications. 19,20 a CLARITY: Centre for Sensor Web Technologies, National Centre for Sensor…”

Section: Introductionmentioning

confidence: 99%

Probing the specific ion effects of biocompatible hydrated choline ionic liquids on lactate oxidase biofunctionality in sensor applications

Curto

Scheuermann

Owens

et al. 2014

Phys. Chem. Chem. Phys.

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This paper presents an extended study on the ion effects of a series of biocompatible hydrated choline based ionic liquids (ILs) on lactate oxidase (LOx), an important enzyme in biosensing technology for the in vitro detection of lactic acid. Secondary structural analysis revealed changes in the protein conformation in hydrated ILs, while thermal unfolding/aggregation dynamics showed different profiles in the presence or absence of ILs. Moreover, LOx thermally denaturised at 90 1C showed residual activity in the presence of chloride and dihydrogen phosphate anions. Kinetic and lifetime studies were also performed, providing a better understanding of the ion effects of ILs on the biocatalytic activity of the enzyme.

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“…Mature anthers were rinsed in 10% (v/v) sucrose solution to remove viscosity. The released pollen grains were then suspended in 1% (v/v) IL in absolute ethanol for 10 s. The IL used in this study was choline lactate { [Ch][CH 3 C(OH)CO 2 ], a clear and fluid liquid at room temperature} that was highly purified (Vijayaraghavan et al, 2010) to make it usable in SEM analysis. Pollen grains were pipetted well and then transferred onto conductive carbon tape.…”

Section: Ionic Liquid Treatmentmentioning

confidence: 99%

SEM Observation of Wet Lily Pollen Grains Pretreated with Ionic Liquid

Komai

Okada

Inoue

et al. 2014

J. Japan. Soc. Hort. Sci.

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Mature pollen grains of Lilium cultivar, with their germ pores folded in upon themselves, were observed under a scanning electron microscope (SEM). The conventional pretreatment process requires aldehyde fixation, dehydration, drying and metal sputtering for SEM observation. These complicated and laborious procedures can considerably alter the morphology of pollen grains. In order to omit this conventional pretreatment process, we established a novel technique utilizing an ionic liquid (IL) that is composed solely of ions, namely, a liquid salt that can remain in a molten state even at room temperature. IL-treated pollen grains could be observed under vacuum conditions without artifacts, and furthermore, a satisfactory SEM image could visualize pollen grains in a wet state. The possible direction of future studies on ionic liquids in the SEM field is also discussed.

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Biocompatibility of choline salts as crosslinking agents for collagen based biomaterials

Cited by 95 publications

References 31 publications

Biocompatible Ionic Liquid–Biopolymer Electrolyte-Enabled Thin and Compact Magnesium–Air Batteries

Biocompatible Ionic Liquid–Biopolymer Electrolyte-Enabled Thin and Compact Magnesium–Air Batteries

Probing the specific ion effects of biocompatible hydrated choline ionic liquids on lactate oxidase biofunctionality in sensor applications

SEM Observation of Wet Lily Pollen Grains Pretreated with Ionic Liquid

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