Biocompatibility of chitosan/Mimosa tenuiflora scaffolds for tissue engineering

Martel-Estrada, Santos-Adriana; Rodríguez-Espinoza, Brenda; Santos-Rodríguez, Elí; Jiménez-Vega, Florinda; García-Casillas, Perla E.; Martínez-Pérez, Carlos A.; Olivas–Armendáriz, I.

doi:10.1016/j.jallcom.2015.01.034

Cited by 26 publications

(9 citation statements)

References 16 publications

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“…10 In recent years, the study of extracts and powder of this plant for medical applications and in tissue engineering has increased. [10][11][12][13][14] According to the properties described above, it is reasonable to expect that a blend of O-carboxymethyl chitosan (OCMC) and Mimosa tenuiflora could have potential use in tissue engineering. So, in order to evaluate the potential application of the composite as a wound dressing, in this work, the synthesis, morphology, mechanical properties, contact angle, swelling test, enzymatic degradation, antimicrobial properties, in vitro biocompatibility, and wound healing of the film were evaluated.…”

Section: Introductionmentioning

confidence: 99%

Characterization and evaluation of a novel O-carboxymethyl chitosan films with Mimosa tenuiflora extract for skin regeneration and wound healing

Valencia-Gómez

Martel-Estrada

Vargas-Requena

et al. 2019

Journal of Bioactive and Compatible Polymers

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In this study, films of O-carboxymethyl chitosan with Mimosa tenuiflora extract were manufactured, characterized, and evaluated. In this work, both the synthesis of O-carboxymethyl chitosan and the extraction of the active ingredient of Mimosa tenuiflora extract from the cortex are described. First, the extract of Mimosa tenuiflora in water was obtained by precipitation with ethanol, filtering, and concentrating. Subsequently, a study was conducted of scratch wound healing to determine the optimal concentration of extract to be used in the manufacture of films. The produced O-carboxymethyl chitosan films and the Mimosa tenuiflora extract were mixed, and their chemical composition, tensile properties, and wettability were characterized by Fourier-transform infrared spectroscopy, mechanical tests, and contact angle measurement. The antimicrobial properties of the films were tested by turbidimetry using two types of bacteria. In addition, a study of the enzymatic degradation of the films with the enzyme lysozyme was performed. Finally, in vitro studies to assess the biocompatibility and cytotoxicity of films with fibroblastic cells were carried out as well as the kinetic analysis of healing in mice. It was found that the addition of Mimosa tenuiflora extract in the polymer matrix of the films made with O-carboxymethyl chitosan improves the proliferation of fibroblast and accelerates wound healing, thus providing a novel biomaterial for skin regeneration.

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Section: Introductionmentioning

confidence: 99%

Characterization and evaluation of a novel O-carboxymethyl chitosan films with Mimosa tenuiflora extract for skin regeneration and wound healing

Valencia-Gómez

Martel-Estrada

Vargas-Requena

et al. 2019

Journal of Bioactive and Compatible Polymers

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“…M. tenuiflora cortex , a kind of plant easily harvested in Mexico, has been used for decades as a remedy in the treatment of wounds and burns of the skin. In a study, different proportions of M. tenuiflora were incorporated into chitosan and divided into three groups [ 10 ]. Incorporating M. tenuiflora cortex to chitosan would obtain a composite containing the beneficial properties of the two components.…”

Section: Plant Derivatives In Tissue Engineeringmentioning

confidence: 99%

Plants and Their Bioactive Constituents in Mesenchymal Stem Cell-Based Periodontal Regeneration: A Novel Prospective

Xue

2018

BioMed Research International

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Periodontitis is a common chronic inflammatory disease, which causes the destruction of both the soft and mineralized tissues. However, current treatments such as bone graft materials, barrier membranes, and protein products all have difficulties in regenerating the complete periodontal tissue structure. Stem cell-based tissue engineering has now emerged as one of the most effective treatments for the patients suffering from periodontal diseases. Plants not only can be substrates for life processes, but also contain hormones or functional molecules. Numbers of preclinical studies have revealed that products from plant can be successfully applied in modulating proliferation and differentiation of human mesenchymal stem cells. Plant-derived substances can induce stem cells osteogenic differentiation, and they also possess angiogenic potency. Furthermore, in the field of tissue engineering, plant-derived compounds or plant extracts can be incorporated with biomaterials or utilized as biomaterials for cell transplantation. So it is speculated that botanical products may become a new perspective in stem cell-based periodontal regeneration. However, the lack of achieving predict clinical efficacy and quality control has been the major impediment to its extensive application. This review gives an overview of the prospect of applying different plant-derived substances in various human mesenchymal stem cells-based periodontal regeneration.

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“…This can be explained by the re-epithelialization process in wounded areas which is believed to be aided by BS. So, the ability to heal, together with the anti-inflammatory and antimicrobial activity of BS demonstrate its potential in tissue engineering applications [ 71 ].…”

Section: Systemic Effectmentioning

confidence: 99%

Critical Analysis on Characterization, Systemic Effect, and Therapeutic Potential of Beta-Sitosterol: A Plant-Derived Orphan Phytosterol

et al. 2016

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Beta-sitosterol (BS) is a phytosterol, widely distributed throughout the plant kingdom and known to be involved in the stabilization of cell membranes. To compile the sources, physical and chemical properties, spectral and chromatographic analytical methods, synthesis, systemic effects, pharmacokinetics, therapeutic potentials, toxicity, drug delivery and finally, to suggest future research with BS, classical as well as on-line literature were studied. Classical literature includes classical books on ethnomedicine and phytochemistry, and the electronic search included Pubmed, SciFinder, Scopus, the Web of Science, Google Scholar, and others. BS could be obtained from different plants, but the total biosynthetic pathway, as well as its exact physiological and structural function in plants, have not been fully understood. Different pharmacological effects have been studied, but most of the mechanisms of action have not been studied in detail. Clinical trials with BS have shown beneficial effects in different diseases, but long-term study results are not available. These have contributed to its current status as an “orphan phytosterol”. Therefore, extensive research regarding its effect at cellular and molecular level in humans as well as addressing the claims made by commercial manufacturers such as the cholesterol lowering ability, immunological activity etc. are highly recommended.

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Biocompatibility of chitosan/Mimosa tenuiflora scaffolds for tissue engineering

Cited by 26 publications

References 16 publications

Characterization and evaluation of a novel O-carboxymethyl chitosan films with Mimosa tenuiflora extract for skin regeneration and wound healing

Characterization and evaluation of a novel O-carboxymethyl chitosan films with Mimosa tenuiflora extract for skin regeneration and wound healing

Plants and Their Bioactive Constituents in Mesenchymal Stem Cell-Based Periodontal Regeneration: A Novel Prospective

Critical Analysis on Characterization, Systemic Effect, and Therapeutic Potential of Beta-Sitosterol: A Plant-Derived Orphan Phytosterol

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