Biocompatibility, Biodistribution, and Drug‐Delivery Efficiency of Mesoporous Silica Nanoparticles for Cancer Therapy in Animals

Abstract

Mesoporous silica nanoparticles (MSNs) are a promising material for drug delivery. In this Full Paper, MSNs are first shown to be well tolerated, as demonstrated by serological, hematological, and histopathological examinations of blood samples and mouse tissues after MSN injection. Biodistribution studies using human cancer xenografts are carried out with in vivo imaging and fluorescent microscopy imaging, as well as with inductively coupled plasma mass spectroscopy. The results show that MSNs preferentially accumulate in tumors. Finally, the drug-delivery capability of MSNs is demonstrated by following tumor growth in mice treated with camptothecin-loaded MSNs. These results indicate that MSNs are biocompatible, preferentially accumulate in tumors, and effectively deliver drugs to the tumors and suppress tumor growth.

Biocompatibility assessment of functionalized magnetic mesoporous silica nanoparticles in human HepaRG cells

“…Mesoporous silica nanocarriers (MSNs) are one of the most promising nanomaterials for drug delivery in nanomedicine because of their outstanding features, such as easy synthesis, tunable size, tailorable pore volume, and highly versatile surface (Lu et al 2010;Yang, Gai, and Lin 2012). Silanol groups present on the surface of MSNs can be functionalized with various ligands, which could be one way of controlling nanoparticle (NP) biodistribution and the design of specific targeted delivery systems (Bouchoucha et al 2016;Li et al 2016).…”

A lucrative chemical processing of bamboo leaf biomass to synthesize biocompatible amorphous silica nanoparticles of biomedical importance

“…The use of silica nanoparticles are extensive in biomedical field by synthesizing as a good biocompatible nanomaterial which can be used in drug delivery (Huang et al 2014), enzyme encapsulation (Ab Wab et al 2014), stabilising agent in therapeutics (Lu et al 2010) and other therapeutic applications (Li et al 2012). In addition, agricultural application of amorphous nanosilica has also been inspected in our previous study to overcome the shortage of silica in soil as well as bio-control action in plants and to enhance morphological and physiological parameters and diseases resistance (Suriyaprabha et al 2012.…”

The Effect of Mesoporous Silica Particles on Stem Cell Differentiation

“…Toxicological data from in vitro and in vivo studies suggest that unloaded MSPs have no observable harmful effects and are well tolerated. [8][9][10] However the possible influence of MSPs, used in our studies, on stem cell differentiation and on the non-neuronal response in the central nervous system has not been examined previously. Here we tested the effect of unloaded MSPs on in vitro differentiation of boundary cap neural crest stem cells (bNCSCs), a source of stem cells with remarkable therapeutic potential, and also analyzed the fate of MSPs at different time points after implantation into the spinal cord and on its surface.…”