Biocompatibility and mechanical properties of pigeon bone waste extracted natural nano-hydroxyapatite for bone tissue engineering

Sharifianjazi, Fariborz; Esmaeilkhanian, Amirhossein; Moradi, Mostafa; Pakseresht, Amirhossein; Asl, Mehdi Shahedi; Karimi-Maleh, Hassan; Jang, Ho Won; Shokouhimehr, Mohammadreza; Varma, Rajender S.

doi:10.1016/j.mseb.2020.114950

Cited by 65 publications

(33 citation statements)

References 54 publications

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“…3. The images re ect the white colored-nature of HAp powders, which is a typical color of HAp powder [24][25][26][27][28][29][30][31][32][33]. It is also important to note that the SEM images re ected irregular morphology.…”

Section: Sem/ Eds Analysismentioning

confidence: 99%

Mechanical Reliability and Modeling of Hydroxyapatite Scaffold

Abifarin¹

2021

Preprint

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Significant contributions on the improvement of the mechanical properties of hydroxyapatite (HAp) have been widely reported. However, failure analysis (mechanical reliability) and modeling are missing. This article filled the gap by conducting Two-parameter Weibull distribution assisted by modeling to investigate the mechanical reliability of HAp. The employed HAp was characterized under SEM/EDS analysis. The results revealed the characteristics of HAp and also the nature of the synthesis route employed through its irregular morphology. The Two-parameter Weibull distribution analysis was conducted on the hardness and compressive strength of HAp scaffold. The characteristic hardness and compressive strength, coupled with their corresponding bounds, failure rates, and correlation coefficients were been presented. The Weibull analysis with the assistance of modeling revealed HAp fabricated under 10 KN compaction load and sintered at 1100 oC as the most reliable sample under hardness condition, while HAp fabricated under 15 KN compaction load and sintered at 1000 oC gave the most reliable characteristic under compression. However, 15 KN compaction load and 1100 oC sintering temperature showed the best reliability on the overall mechanical (hardness and compressive strength) reliability. Future study is recommended on the reliability of HAp scaffolds considering other mechanical properties that are essential for biomedical application.

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Section: Sem/ Eds Analysismentioning

confidence: 99%

Mechanical Reliability and Modeling of Hydroxyapatite Scaffold

Abifarin¹

2021

Preprint

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“…The average particle size of the prepared nHA was in the range of 50-250 nm; the Ca/P ratio (sintering at 1050 • C) was 1.7; hardness and compressive strength of sintered nHA were increased to 47.57 MPa and 3.7 GPa, respectively. A significant improvement in the activity and proliferation of osteoblast cells was proven compared to synthetic nHA [107].…”

Section: Nano-hydroxyapatitementioning

confidence: 99%

“…It is used in various applications such as bone tissue engineering, implantology, surgery, periodontol-ogy, esthetics, and prevention, for example, as a coating material for titanium implants in dentistry also showing antibacterial activity, as a grafting material, or as material with remineralizing potential [105,106]. It can be isolated from bio-waste materials, for example, Fariborz et al [107] used the ball milling process after annealing waste pigeon bones at 850 • C followed by cold-pressing of the NPs and resintering at 850, 950, 1050, and 1150 • C for nHA preparation. The average particle size of the prepared nHA was in the range of 50-250 nm; the Ca/P ratio (sintering at 1050 • C) was 1.7; hardness and compressive strength of sintered nHA were increased to 47.57 MPa and 3.7 GPa, respectively.…”

Section: Nano-hydroxyapatitementioning

confidence: 99%

Advances in Use of Nanomaterials for Musculoskeletal Regeneration

Jampílek

Plachá

2021

Pharmaceutics

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Since the worldwide incidence of bone disorders and cartilage damage has been increasing and traditional therapy has reached its limits, nanomaterials can provide a new strategy in the regeneration of bones and cartilage. The nanoscale modifies the properties of materials, and many of the recently prepared nanocomposites can be used in tissue engineering as scaffolds for the development of biomimetic materials involved in the repair and healing of damaged tissues and organs. In addition, some nanomaterials represent a noteworthy alternative for treatment and alleviating inflammation or infections caused by microbial pathogens. On the other hand, some nanomaterials induce inflammation processes, especially by the generation of reactive oxygen species. Therefore, it is necessary to know and understand their effects in living systems and use surface modifications to prevent these negative effects. This contribution is focused on nanostructured scaffolds, providing a closer structural support approximation to native tissue architecture for cells and regulating cell proliferation, differentiation, and migration, which results in cartilage and bone healing and regeneration.

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“…The large percentage of these side effects necessitates the use of secondary surgical methods to remove the stents. Because of a clear shortage of currently existing stents, there is a significant therapeutic need for biodegradable airway stents that would maintain airway patency and then be completely degrade overtime after achieving the intended goals [32].…”

Section: Application Of Biodegradable Mg Alloys In Orthopedic Implantsmentioning

confidence: 99%

A review of additive manufacturing of Mg-based alloys and composite implants

Zamani

Ghazanfari

Erabi

et al. 2021

jcc

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Magnesium based materials are considered promising biodegradable metals for orthopedic bone implant applications as they exhibit similar density and elastic modulus to that of bone, biodegradability, and excellent osteogenic properties. The use of Mg based biomaterials eliminates the limitations of currently used implant materials such as stress shielding and the need for the second surgery. Recently, the development of Mg-based implants has attracted significant attention. Additive manufacturing is one of the effective techniques to develop Mg based implants. Additive manufacturing which could be named 3D printing is a transformative and rapid method of producing industrial parts with in the acceptable dimensional range. Therefore, recent investigations have tried to apply this method for the development of Mg-based implants. This state-of-the-art review focuses on the additive manufacturing of Mg biodegradable materials and their in-vitro corrosion and degradation, and mechanical properties. The future directions to develop Mg biodegradable materials are reported through summarization of current achievements.

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Biocompatibility and mechanical properties of pigeon bone waste extracted natural nano-hydroxyapatite for bone tissue engineering

Cited by 65 publications

References 54 publications

Mechanical Reliability and Modeling of Hydroxyapatite Scaffold

Mechanical Reliability and Modeling of Hydroxyapatite Scaffold

Advances in Use of Nanomaterials for Musculoskeletal Regeneration

A review of additive manufacturing of Mg-based alloys and composite implants

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