Biocompatibility and interference eliminating property of pullulan acetate/polyethylene glycol/heparin membrane for the outer layer of an amperometric glucose sensor

Sung, Won Jun; Na, Kun; Bae, You Han

doi:10.1016/j.snb.2003.12.005

Cited by 32 publications

(17 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, reduction in local tissue inflammation and enhancement in vascularity have been achieved through drug delivery approaches that utilize biocompatible sensor coatings capable of delivering tissue response modifiers (TRMs) at the implant site. For example, antiinflammatory drugs (dexamethasone 142,148,149 ), neovascularization-inducing growth factors (vascular endothelial growth factor and platelet-derived growth factor 143,150 ), vasodilators (nitric oxide [151][152][153] ), and anti-coagulants (heparin 154 ) have been incorporated into sensor coatings. However, while these TRMs are able to inhibit the foreign body response, their beneficial action can only be maintained so long as their release is sustained.…”

Section: Inflammation Foreign Body Response and Biofoulingmentioning

confidence: 99%

Technologies for Continuous Glucose Monitoring: Current Problems and Future Promises

Vaddiraju

Burgess

Tomazos

et al. 2010

J Diabetes Sci Technol

229

224

View full text Add to dashboard Cite

Devices for continuous glucose monitoring (CGM) are currently a major focus of research in the area of diabetes management. It is envisioned that such devices will have the ability to alert a diabetes patient (or the parent or medical care giver of a diabetes patient) of impending hypoglycemic/hyperglycemic events and thereby enable the patient to avoid extreme hypoglycemic/hyperglycemic excursions as well as minimize deviations outside the normal glucose range, thus preventing both life-threatening events and the debilitating complications associated with diabetes. It is anticipated that CGM devices will utilize constant feedback of analytical information from a glucose sensor to activate an insulin delivery pump, thereby ultimately realizing the concept of an artificial pancreas. Depending on whether the CGM device penetrates/breaks the skin and/or the sample is measured extracorporeally, these devices can be categorized as totally invasive, minimally invasive, and noninvasive. In addition, CGM devices are further classified according to the transduction mechanisms used for glucose sensing (i.e., electrochemical, optical, and piezoelectric). However, at present, most of these technologies are plagued by a variety of issues that affect their accuracy and long-term performance. This article presents a critical comparison of existing CGM technologies, highlighting critical issues of device accuracy, foreign body response, calibration, and miniaturization. An outlook on future developments with an emphasis on long-term reliability and performance is also presented.

show abstract

Section: Inflammation Foreign Body Response and Biofoulingmentioning

confidence: 99%

Technologies for Continuous Glucose Monitoring: Current Problems and Future Promises

Vaddiraju

Burgess

Tomazos

et al. 2010

J Diabetes Sci Technol

229

224

View full text Add to dashboard Cite

show abstract

“…Sensors with a composite coating [57][58][59][60][61][62][63][64][65][66][67] include sensors with metal-oxide composites, sensors with metal-inorganic composites, sensors with metal-polymer composites, sensors with oxide-organic com NONENZIMATIC AMPEROMETRIC GLUCOSE BIOSENSORS 157 posites, sensors with dihydroxide composites, sensors with dihydroxide-organic composites, and sensors with polymer composites. Wang et al fabricated a sensor with a metal-oxide composite.…”

Section: Monometallic Sensors With Single Coatingmentioning

confidence: 99%

Nonenzimatic amperometric glucose biosensors

Buzanovskii¹

2012

Ref. J. Chem.

View full text Add to dashboard Cite

show abstract

“…These materials showed greatly reduced platelet adhesion when tested in static whole blood for 64 h compared with polyurethane and poly(vinyl chloride) membranes. Sung membrane as a surface coating for intravascular amperometric glucose sensors (26). In vitro plateletadhesion studies conducted with platelet-rich plasma demonstrated a significant reduction in adhered platelets when compared with other outer-membrane materials, including biomedicalgrade polyurethanes.…”

Section: Improving Biocompatibility Of Intravascular Sensorsmentioning

confidence: 99%