Biocompatibility and in vitro antineoplastic drug-loaded trial of titania nanotubes prepared by anodic oxidation of a pure titanium

Xiao, Xilin; Yang, Lixia; Guo, Minzhe; Pan, Chunfeng; Cai, Qingyun; Yao, Shouzhuo

doi:10.1007/s11426-009-0240-7

Cited by 20 publications

(16 citation statements)

References 21 publications

(30 reference statements)

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“…Metal oxide nanotubes, such as nanotubular titania (TiO 2 ), which were discovered in the 1990s, are non-toxic and potentially useful materials for many applications, including biomedical ones [128][129][130] and are thermally stable and corrosion resistant [131][132][133]. They have the same advantages associated with scale that are found in carbon nanotubes, and unlike carbon nanotubes, they can be manufactured at low cost by hydrothermal, electrochemical and surfactant template techniques, [132,134,135] This makes PPy/TiO2 nanocomposites a good candidates for drug delivery systems [131].…”

Section: Nanotubular Structuresmentioning

confidence: 99%

“…They have the same advantages associated with scale that are found in carbon nanotubes, and unlike carbon nanotubes, they can be manufactured at low cost by hydrothermal, electrochemical and surfactant template techniques, [132,134,135] This makes PPy/TiO2 nanocomposites a good candidates for drug delivery systems [131]. However, TiO 2 have large bandgap and can be considered as semiconductor materials [136,137].…”

Section: Nanotubular Structuresmentioning

confidence: 99%

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Electrodeposited conductive polymers for controlled drug release: polypyrrole

Alshammary

Walsh

Herrasti

et al. 2015

J Solid State Electrochem

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Over the last 40 years, electrically conductive polymers have become well established as important electrode materials. Polyanilines, polythiophenes and polypyrroles have received particular attention due to their ease of synthesis, chemical stability, mechanical robustness and the ability to tailor their properties. Electrochemical synthesis of these materials as films have proved to be a robust and simple way to realise surface layers with controlled thickness, electrical conductivity and ion transport. In the last decade, the biomedical compatibility of electrodeposited polymers has become recognised; in particular, polypyrroles have been studied extensively and can provide an effective route to pharmaceutical drug release. The factors controlling the electrodeposition of this polymer from practical electrolytes are considered in this review including electrolyte composition and operating conditions such as the temperature and electrode potential. Voltammetry and current-time behaviour are seen to be effective techniques for film characterisation during and after their formation. The degree of take-up and the rate of drug release depend greatly on the structure, composition and oxidation state of the polymer film. Specialised aspects are considered, including galvanic cells with a Mg anode, use of catalytic nanomotors or implantable biofuel cells for a self-powered drug delivery system and nanoporous surfaces and nanostructures. Following a survey of polymer and drug types, progress in this field is summarised and aspects requiring further research are highlighted.

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Section: Nanotubular Structuresmentioning

confidence: 99%

Section: Nanotubular Structuresmentioning

confidence: 99%

Electrodeposited conductive polymers for controlled drug release: polypyrrole

Alshammary

Walsh

Herrasti

et al. 2015

J Solid State Electrochem

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“…The biocompatibility of the as-prepared TNTs was studied by observing the growth of osteosarcoma (MG-63) cells on the TNT surface, and TNTs loaded with the antineoplastic drug were investigated by using MG-63 cells as targets and cisplatin as the model drug. 131 Their results demonstrated that TNTs show excellent biocompatibility and can be used as a drug delivery vehicle, with efficient drug loading and releasing ability to significantly suppress the growth of MG-63 cells. Moreover, Kalbacova et al demonstrated that TNTs can be used as a photocatalyst to kill cancer cells.…”

Section: Brain Tumorsmentioning

confidence: 99%

TiO<sub>2</sub> nanotube platforms for smart drug delivery: a review

Wang

Huang

et al. 2016

IJN

117

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Titania nanotube (TNT) arrays are recognized as promising materials for localized drug delivery implants because of their excellent properties and facile preparation process. This review highlights the concept of localized drug delivery systems based on TNTs, considering their outstanding biocompatibility in a series of ex vivo and in vivo studies. Considering the safety of TNT implants in the host body, studies of the biocompatibility present significant importance for the clinical application of TNT implants. Toward smart TNT platforms for sustainable drug delivery, several advanced approaches were presented in this review, including controlled release triggered by temperature, light, radiofrequency magnetism, and ultrasonic stimulation. Moreover, TNT implants used in medical therapy have been demonstrated by various examples including dentistry, orthopedic implants, cardiovascular stents, and so on. Finally, a future perspective of TNTs for clinical applications is provided.

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“…The geometry of TiO 2 nanotube as a membrane makes it appropriate for placement for both injected capsules and biomedical implant [2]. Xiao and his workers [3] showed outstanding biocompatibility of both TiO 2 nanotube arrays that prepared by anodisation and annealed in a carbon atmosphere. Application of drug delivery system was accomplished by various methods [4].…”

Section: Introduction:-mentioning

confidence: 99%