Biocompatibility and Hyperthermia Efficiency of Sonochemically Synthesized Magnetic Nanoparticles

Abstract

Hereby, a sonochemical method for synthesis of pure magnetic Fe3O4 nanoparticles (Fe3O4-NPs) in large scale is being introduced. Synthesis proceeds via simple approach, at room temperature, under sonication, using cheap reagents, green antioxidant-reductant reagent and without using inert gas purge as protective atmosphere condition. During this procedure, hydrogen gas releases continuously as valuable byproduct at the anaerobic step of reaction. Characterizations’ results indicate that the final product is pure spherical Fe3O4-NPs, with narrow size distribution and about less than 32[Formula: see text]nm in mean diameter while more than 99% of particles size were less than 40[Formula: see text]nm. According to Vibrational Sampling Magnetometer (VSM) result, NPs pose high saturation magnetization of about 77 (emu/g) and magnetization curve shows superparamagnetic behavior with no hysteresis loop. Also by various weight ratios, these NPs performed stable dispersion in aqueous media for long times. Iron oxide NPs show nontoxicity for lower dosage of 10[Formula: see text][Formula: see text][Formula: see text]g/mL in 24[Formula: see text]h on fibroblast cell. Hyperthermia results show maximum heating efficiency in 100[Formula: see text]KHz for 1[Formula: see text]mg/mL of NPs.

Simple Sonochemical Method to Optimize the Heating Efficiency of Magnetic Nanoparticles for Magnetic Fluid Hyperthermia

“…Recent advances in the experimental observation of the Néel relaxation contribution in Fe 3 O 4 MNPs obtained by thermal decomposition (<20 nm) in a clinical setting ( H = 16.2 kA/m; f = 110 kHz) show decreasing SLP values from 67 W/g in a solution to 25 W/g in a gel medium. 39 On the other hand, spherical Fe 3 O 4 (<14 nm) obtained by a chemical route shows a decreasing dependence on heat dissipation in agar media. The SLP values decreased from 200 to 140 W/g as the agar concentration increased (<7%).…”

“…The SLP value of 60 W/g of the sonochemically synthesized MNPs recently published in the literature was evaluated in aqueous media that included Brownian contributions. Recent advances in the experimental observation of the Néel relaxation contribution in Fe 3 O 4 MNPs obtained by thermal decomposition (<20 nm) in a clinical setting ( H = 16.2 kA/m; f = 110 kHz) show decreasing SLP values from 67 W/g in a solution to 25 W/g in a gel medium . On the other hand, spherical Fe 3 O 4 (<14 nm) obtained by a chemical route shows a decreasing dependence on heat dissipation in agar media.…”

Applications of Non‐precious Transition Metal Oxide Nanoparticles in Electrochemistry

“…The preparation procedure involved reaction of Fe (III) with Fe (0) in aqueous media, which released H 2 gas as one of the worthwhile by-products. According to the characterization outputs, the resultant product is the pure spherical Fe 3 O 4 -NPs with narrower size distribution and nearly a mean diameter of < 32 nm where the size has been < 40 nm in more than 99 % of particles [60].…”

Effects of Electromagnets on Bovine Corneal Endothelial Cells Treated with Dendrimer Functionalized Magnetic Nanoparticles

“…The use of magnetic nanoparticles (MNPs) coupled with magnetic base devices has been increasing in the biomedical field [1][2][3][4]. Among them, superparamagnetic iron oxide nanoparticles (SPIONs) are widely used in nanomedicine for diagnoses, therapeutics, drug, and gene delivery systems [5][6][7][8]. To enhance SPION biocompatibility, solubility, and stability in physiological conditions, surface modifications with biocompatible polymers are necessary.…”