2012
DOI: 10.1016/j.biomaterials.2012.06.018
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Biocompatibility and degradation characteristics of PLGA-based electrospun nanofibrous scaffolds with nanoapatite incorporation

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Cited by 155 publications
(107 citation statements)
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References 27 publications
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“…The decrease in the pH (acidic environment) during scaffold degradation leads to the agglomeration of the particles, which immobilizes them and prevents adverse effects commonly induced by nanoscale materials. The fast degradation might be considered an undesirable feature in theory, since previous studies have shown that the slower the degradation, the better the host response, [ 28 ] but in fact this was not seen in our study, probably attributed to nDP and BMP-2 modifi cations. Although the nDP and nDP+BMP-2 scaffolds that degraded faster had elevated mRNA levels of proinfl ammatory markers relative to PLCL at week 1, the infl ammatory cells present histologically in the site, particularly chronic infl ammation cells, were signifi cantly less at the later time points.…”
Section: Discussioncontrasting
confidence: 64%
See 1 more Smart Citation
“…The decrease in the pH (acidic environment) during scaffold degradation leads to the agglomeration of the particles, which immobilizes them and prevents adverse effects commonly induced by nanoscale materials. The fast degradation might be considered an undesirable feature in theory, since previous studies have shown that the slower the degradation, the better the host response, [ 28 ] but in fact this was not seen in our study, probably attributed to nDP and BMP-2 modifi cations. Although the nDP and nDP+BMP-2 scaffolds that degraded faster had elevated mRNA levels of proinfl ammatory markers relative to PLCL at week 1, the infl ammatory cells present histologically in the site, particularly chronic infl ammation cells, were signifi cantly less at the later time points.…”
Section: Discussioncontrasting
confidence: 64%
“…The presence and quality of fi brous capsules and the type and amounts of cells were randomly evaluated in six fi elds of vision (magnifi cation 400×) of the entire implant area of each section using a modifi ed scoring system. [ 28 ] Histopathological examination of tissue specimens was limited to the tissue inside the scaffold and that in direct contact with it, evaluating the presence of different types of cells: those involved in early responses (neutrophils and plasma cells) and those involved in late or chronic responses (lymphocytes and foreign body giant cells). The grading for histological scoring is summarized in with ≈6-8 µm pixel size, 50 kV, aluminum 0.5 mm fi lter, and 0.4° rotation step.…”
Section: Descriptive Semiquantitative Histological Evaluationmentioning
confidence: 99%
“…No residual hydrogel was detected by MRI with in situ polymerized PFGdDTPA-Cy5.5 on the third week of the experiment. These results are consistent with previous studies that use other techniques to document how in vivo fate of biomaterial implants is dependent on the composition, dimensions, in situ environment, and degradation products (13,15,(26)(27)(28). In the context of hydrogel biomaterial implants specifically, the MRI results are in close agreement with the work of Artzi et al (15); they also showed that implant geometry significantly affects the in vivo degradation patterns of the implant.…”
Section: Significancesupporting
confidence: 91%
“…The specific structures-filopodia and lamellipodia-related to the cell motility of fibroblasts can be observed both from SEM and CLSM micrographs. The cells emit cytoplasmic process towards the fibers and neighboring cells, communicating with the surrounding micro-environment and neighboring cells and allowing the passage of messengers [35]. Thus, we can conclude that even with a high content of drug and the use of organic solvent during the electrospinning process, PGH30 has no negative effect on cell morphology, viability, and proliferation.…”
Section: Proliferation Of Cells On Pgh-mna Nanofiber Membranesmentioning
confidence: 82%