Biocompatibility and biodegradability of Mg–Sr alloys: The formation of Sr-substituted hydroxyapatite

Bornapour, Mosayeb; Muja, Naser; Shum‐Tim, Dominique; Cerruti, Marta; Pekguleryuz, Mihriban

doi:10.1016/j.actbio.2012.07.045

Cited by 232 publications

(146 citation statements)

References 65 publications

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“…These results agree with the previous observation, where no inhibitory effect of alkali-heat-treated Mg (NaHCO 3 -MgCO 3 ) was recorded on marrow cell growth [20]. It was observed that Mg-0.5 Sr alloy increases HUVEC viability over a seven day period of exposure.…”

Section: Discussionsupporting

confidence: 83%

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In Vitro Corrosion and Biological Assessment of Bioabsorbable WE43 Mg Alloy Specimens

Galvin

Jaiswal

Lally

et al. 2017

JMMP

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Bioabsorbable magnesium (Mg) alloys have several advantages in biomedical implant applications as they reduce certain risks associated with conventional permanent implants. However, limited information is available for WE43 Mg alloy specimens with comparable size to that of biomedical implants such as cardiovascular stents and orthopaedic wires. The present work examines the corrosion and biological properties of WE43 stent precursor tubes and wire specimens suited for orthopaedic implants. The corrosion-induced loss of mechanical integrity as well as the corrosion-induced changes in surface morphology of the specimens are elucidated and compared. Cell viability assays were performed with human umbilical vein endothelial cells (HUVECs). It was observed that Mg ions released from the WE43 alloy acted as a growth stimulator of HUVECs.

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Section: Discussionsupporting

confidence: 83%

“…The specimens were incubated in 10 mL cell culture medium (medium 200, without supplements) for 72 h in a humidified atmosphere (5% CO 2 , 95% air at 37 • tem) [20]. The samples were acidified in 10% HNO 3 before measuring by ICP.…”

Section: Immersion Testingmentioning

confidence: 99%

In Vitro Corrosion and Biological Assessment of Bioabsorbable WE43 Mg Alloy Specimens

Galvin

Jaiswal

Lally

et al. 2017

JMMP

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“…Highly porous materials corrode very rapidly, as a larger area of the material surface is exposed to the corrosion environment. Corrosion resistance of either pure magnesium or magnesium alloys is seldom suitable for technical applications or even biomedical applications [3,9,[16][17][18][19][20]. Magnesium corrosion resistance can be improved by alloying the metal with aluminum, zinc or rare earth metal elements; however, for significantly better corrosion resistance, another way of reducing the degradation rate must be considered.…”

Section: Introductionmentioning

confidence: 99%

“…Conversion coatings are widely studied as corrosion protection for magnesium and its alloys. Fluoride and calcium phosphate-based conversion coatings have a great potential of reducing the corrosion rate of biomedical magnesium implants [1][2][3][4][12][13][14][15][16][17][18][19][20][21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Characterization of Powder Metallurgy Processed Pure Magnesium Materials for Biomedical Applications

Zapletal

Březina

Krystýnová

et al. 2017

Metals

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Magnesium with its mechanical properties and nontoxicity is predetermined as a material for biomedical applications; however, its high reactivity is a limiting factor for its usage. Powder metallurgy is one of the promising methods for the enhancement of material mechanical properties and, due to the introduced plastic deformation, can also have a positive influence on corrosion resistance. Pure magnesium samples were prepared via powder metallurgy. Compacting pressures from 100 MPa to 500 MPa were used for samples' preparation at room temperature and elevated temperatures. The microstructure of the obtained compacts was analyzed in terms of microscopy. The three-point bending test and microhardness testing were adopted to define the compacts' mechanical properties, discussing the results with respect to fractographic analysis. Electrochemical corrosion properties analyzed with electrochemical impedance spectroscopy carried out in HBSS (Hank's Balanced Salt Solution) and enriched HBSS were correlated with the metallographic analysis of the corrosion process. Cold compacted materials were very brittle with low strength (up to 50 MPa) and microhardness (up to 50 HV (load: 0.025 kg)) and degraded rapidly in both solutions. Hot pressed materials yielded much higher strength (up to 250 MPa) and microhardness (up to 65 HV (load: 0.025 kg)), and the electrochemical characteristics were significantly better when compared to the cold compacted samples. Temperatures of 300 • C and 400 • C and high compacting pressures from 300 MPa to 500 MPa had a positive influence on material bonding, mechanical and electrochemical properties. A compacting temperature of 500 • C had a detrimental effect on material compaction when using pressure above 200 MPa.

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“…Magnesium alloys possess very selective mechanical properties which result in materials that are light, biodegradable and biocompatible [25][26][27][28][29][30]. An important aspect of these materials is their mechanical properties which are specifically important for different biomedical applications: such as cardiovascular stents or orthopedic devices.…”

Section: Icp-ms) A) Concentration Of Magnesium (Ii) Ions B) Concentmentioning

confidence: 99%

An Assessment of Novel Biodegradable Magnesium Alloys for Endovascular Biomaterial Applications

Persaud-Sharma¹

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Biocompatibility and biodegradability of Mg–Sr alloys: The formation of Sr-substituted hydroxyapatite

Cited by 232 publications

References 65 publications

In Vitro Corrosion and Biological Assessment of Bioabsorbable WE43 Mg Alloy Specimens

In Vitro Corrosion and Biological Assessment of Bioabsorbable WE43 Mg Alloy Specimens

Characterization of Powder Metallurgy Processed Pure Magnesium Materials for Biomedical Applications

An Assessment of Novel Biodegradable Magnesium Alloys for Endovascular Biomaterial Applications

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