In Vitro Corrosion and Biological Assessment of Bioabsorbable WE43 Mg Alloy Specimens

Abstract

Bioabsorbable magnesium (Mg) alloys have several advantages in biomedical implant applications as they reduce certain risks associated with conventional permanent implants. However, limited information is available for WE43 Mg alloy specimens with comparable size to that of biomedical implants such as cardiovascular stents and orthopaedic wires. The present work examines the corrosion and biological properties of WE43 stent precursor tubes and wire specimens suited for orthopaedic implants. The corrosion-induced loss of mechanical integrity as well as the corrosion-induced changes in surface morphology of the specimens are elucidated and compared. Cell viability assays were performed with human umbilical vein endothelial cells (HUVECs). It was observed that Mg ions released from the WE43 alloy acted as a growth stimulator of HUVECs.

Predicting localised corrosion and mechanical performance of a PEO surface modified rare earth magnesium alloy for implant use through in-silico modelling

“…However, through hydrogen tracking, it is possible to monitor mass loss values over time without removing samples, over the full immersion time. Additionally, we determined relationship between mass to other approaches that use hazardous chromic acid for cleaning of specimens [ 27 , 30 , 33 , 74 ]. Although, slightly lower material loss values were detected compared to μCT, this method has the potential to deliver more reliable results as compared to hydrogen evolution.…”

Современные Концепции Изучения Процессов Коррозионной Деградации Материалов И Покрытий: Теория, Практика, Методология Исследований

“…В связи с этим магний и его сплавы рассматриваются как материалы для биорезорбируемых имплантатов, использование которых устраняет необходимость повторной хирургической процедуры для извлечения имплантата после срастания кости [301][302][303][304][305][306]. Важным преимуществом этих материалов по сравнению как с разлагаемыми полимерами, так и с другими металлами является близость механических свойств магния к свойствам кости человека [307].…”

Effect of Fluoride Coatings on the Corrosion Behavior of Mg–Zn–Ca–Mn Alloys for Medical Application

“…The detailed chemical composition of the most involved fluids in research for Mg-based corrosion analyses is described by J. Gonzales et al [ 15 ]. Almost all the physiological media contain inorganic ions such as sodium (Na + ), potassium (K + ), chloride (Cl − ), magnesium (Mg 2+ ), calcium (Ca 2+ ), and chemical radicals such as HCO 3− , HPO 4 2− , H 2 PO 4 − , and SO 4 2− [ 15 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 ].…”