Biocompatibility and bioactivity study of a cytostatic drug belonging to the group of alkylating agents of the triazine derivative class

Mikolaichuk, O. V.; Sharoyko, Vladimir V.; Popova, E.; Protas, A. V.; Fonin, Alexander V.; Vasina, Lubov V.; Anufrikov, Yurii A.; Luttsev, Michail D.; Nashchekina, Iuliia A.; Малкова, Анна; Tochilnikov, Grigorii V.; Ageev, Sergei V.; Semenov, Konstantin N.

doi:10.1016/j.molliq.2021.117630

Cited by 16 publications

(11 citation statements)

References 43 publications

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“…High resolution mass spectral analysis was performed using Shimadzu 9030 and Bruker Daltonik GmbH 'MaXis' instruments. 1 H and 13 C { 1 H} NMR spectra for substance (a) are in good agreement with previously published data in ref. [1].…”

Section: Identification Methodssupporting

confidence: 92%

“…1 H and 13 C { 1 H} NMR spectra for substance (a) are in good agreement with previously published data in ref. [1]. [5-[[4,6-…”

Section: Identification Methodssupporting

confidence: 92%

“…This work continues our research on [5-[[4,6-bis(aziridin-1-yl)-1,3,5-triazin-2yl]amino]-2,2-dimethyl-1,3-dioxan-5-yl]methanol (substance (a)) from the group of alkylating agents of the class of triazine derivatives (Fig. 1) [1]. 1,3,5-Triazine derivatives such as Altretamine (1) [2], Tretamine (2) [3], and Azacitidine (3) [4] (Fig.…”

Section: Introductionsupporting

confidence: 64%

“…Substance (a) cytotoxicity towards pancreas adenocarcinoma (Capan-2) and skin melanoma (SK-MEL-1) cell lines was carried out using MTT-assay. The experimental technique is described elsewhere [1,41].…”

Section: In Vitro Investigation Of Substance (A)mentioning

confidence: 99%

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A cytostatic drug from the class of triazine derivatives: Its properties in aqueous solutions, cytotoxicity, and therapeutic activity

Mikolaichuk

Popova

Protas

et al. 2022

Journal of Molecular Liquids

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Section: Identification Methodssupporting

confidence: 92%

“…1 H and 13 C { 1 H} NMR spectra for substance (a) are in good agreement with previously published data in ref. [1]. [5-[[4,6-…”

Section: Identification Methodssupporting

confidence: 92%

Section: Introductionsupporting

confidence: 64%

Section: In Vitro Investigation Of Substance (A)mentioning

confidence: 99%

See 2 more Smart Citations

A cytostatic drug from the class of triazine derivatives: Its properties in aqueous solutions, cytotoxicity, and therapeutic activity

Mikolaichuk

Popova

Protas

et al. 2022

Journal of Molecular Liquids

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“…It mainly reacts with the side-chain amino groups of collagens to form strong covalent bonds, thus enhancing hydrothermal stability of leather [22]. Compared with other organic tanning agents (e.g., aldehydes and syntan), triazine derivatives can effectively mitigate the health risks due to their biocompatibility [23,24]. Meanwhile, the released H + in tanning process (Additional file 1: Fig.…”

Section: Graphical Abstract 1 Introductionmentioning

confidence: 99%

Sustainable metal-free leather manufacture via synergistic effects of triazine derivative and vegetable tannins

et al. 2023

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Restrictions on heavy metals, especially chromium, have encouraged alternative tanning systems that can reduce environmental and human health risks from conventional chrome-based tanning. In this work, metal-free combination tanning was developed by using vegetable tannins and a triazine-based syntan containing active chlorine groups (SACC). Specifically, the relationship between leather performance (e.g., hydrothermal stability and organoleptic properties) and technical protocols (e.g., types and dose of tannins) was systematically established. The optimized protocol involving a unique procedure (i.e., 10% SACC pre-tanning, shaving, and 25% wattle tanning) endowed the leather with high shrinkage temperature (~ 92 °C) and met the Chinese standards for shoe upper leather (QB/T 1873-2010). Our method not only produces zero chrome-containing solid wastes, but also uses ~ 75% less tannin for leather manufacture. The excellent leather performance was ascribed to the synergistic effects, where SACC and wattle diffused into collagen fibrils and may bind to collagen via covalent, hydrogen and ionic bonding, locking the hierarchical structure of collagen from microfibrils to fiber bundles. Moreover, we summarized these findings and proposed a diffusion-binding-locking mechanism, providing new insights for current tanning theory. Together with the biodegradable spent tanning liquor, this approach will underpin the development of sustainable leather manufacture. Graphical Abstract

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Aziridine‐Functionalized 1,3,5‐Triazine Derivatives as Promising Anticancer Agents: Synthesis, DFT Study, DNA Binding Investigations and In Vitro Cytotoxic Activity

Protas,

Mikolaichuk,

Popova

et al. 2024

Journal of Heterocyclic Chem

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Herein, we report a synthesis and characterization of aziridine‐functionalized 1,3,5‐triazine derivatives. Electronic structure and the most preferable geometry of substances were calculated by DFT method. DNA binding investigations were conducted as part of the biomedicinal research as well as the cytotoxic activity of these compounds was evaluated using in vitro assays toward Huh‐7 and A549 cancer cell lines and HEK‐293 normal cell line. The results demonstrate that some of the synthesized compounds exhibit potent cytotoxic activity ([5‐[[4,6‐bis(aziridin‐1‐yl)‐1,3,5‐triazin‐2‐yl]amino]‐2,2‐dimethyl‐1,3‐dioxan‐5‐yl]methanol (1) and 4,6‐di(aziridine‐1‐yl)‐N‐(2,2,5‐trimethyl‐1,3‐dioxane‐5‐yl)‐1,3,5‐triazine‐2‐amine (9)), making them potential candidates for further development as anticancer agents.

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Biocompatibility and bioactivity study of a cytostatic drug belonging to the group of alkylating agents of the triazine derivative class

Cited by 16 publications

References 43 publications

A cytostatic drug from the class of triazine derivatives: Its properties in aqueous solutions, cytotoxicity, and therapeutic activity

A cytostatic drug from the class of triazine derivatives: Its properties in aqueous solutions, cytotoxicity, and therapeutic activity

Sustainable metal-free leather manufacture via synergistic effects of triazine derivative and vegetable tannins

Aziridine‐Functionalized 1,3,5‐Triazine Derivatives as Promising Anticancer Agents: Synthesis, DFT Study, DNA Binding Investigations and In Vitro Cytotoxic Activity

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